jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)10.31549/2542-1174-2025-9-2-97-111jsms-1201Research ArticleОБЗОРЫREVIEWЭтиопатогенетические аспекты использования пробиотических препаратов у пациентов с ожирением и избыточной массой телаEtiopathogenetic aspects of the use of probiotics in obese and overweight patientshttps://orcid.org/0009-0006-4496-0435КаравозоваА. Е.KaravozovaA. E.

Каравозова Анастасия Евгеньевна – ординатор 1-го года обучения по специальности «Педиатрия» кафедры пропедевтики детских болезней 

630091, г. Новосибирск, Красный просп., 52

Anastasia E. Karavozova – 1st year Resident in the specialty “Pediatrics”, Department of Propedeutics of Childhood Diseases

52, Krasny prosp., Novosibirsk, 630091

nastya_vae100@mail.ruhttps://orcid.org/0009-0007-1119-7258МенщиковаВ. Е.MenshchikovaV. E.

Менщикова Валерия Евгеньевна – аспирант 1-го года обучения по специальности «Педиатрия» кафедры пропедевтики детских болезней

630091, г. Новосибирск, Красный просп., 52

Valeria E. Menshchikova – 1st year Post-graduate Student in the specialty “Pediatrics”, Department of Propedeutics of Pediatric Diseases

52, Krasny prosp., Novosibirsk, 630091

https://orcid.org/0000-0001-7007-1996КарцеваТ. В.KartsevaT. V.

Карцева Татьяна Валерьевна – д-р мед. наук, доцент, заведующий кафедрой пропедевтики детских болезней

630091, г. Новосибирск, Красный просп., 52

Tatiana V. Kartseva – Dr. Sci. (Med.), Associate Professor, Head, Department of Propedeutics of Pediatric Diseases

52, Krasny prosp., Novosibirsk, 630091

https://orcid.org/0000-0002-0990-0078РябиченкоТ. И.RyabichenkoT. I.

Рябиченко Татьяна Ивановна – д-р мед. наук, ведущий научный сотрудник лаборатории иммунологии

Новосибирск

Tatiana I. Ryabichenko – Dr. Sci. (Med.), Leading Researcher, Laboratory of Immunology

Novosibirsk

https://orcid.org/0000-0002-9834-1799ОбуховаО. О.ObukhovaO. O.

Обухова Ольга Олеговна – д-р мед. наук, руководитель лаборатории иммунологии

Новосибирск

Olga O. Obukhova – Dr. Sci. (Med.), Head, Laboratory of Immunology

Novosibirsk

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииРоссияNovosibirsk State Medical UniversityRussian FederationФГБУН «Федеральный исследовательский центр фундаментальной и трансляционной медицины»РоссияFederal Research Center for Fundamental and Translational MedicineRussian Federation2025220620250297111Copyright © Каравозова А.Е., Менщикова В.Е., Карцева Т.В., Рябиченко Т.И., Обухова О.О., 20252025Каравозова А.Е., Менщикова В.Е., Карцева Т.В., Рябиченко Т.И., Обухова О.О.Karavozova A.E., Menshchikova V.E., Kartseva T.V., Ryabichenko T.I., Obukhova O.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/1201

В последние десятилетия ожирение и избыточная масса тела стали одной из существенных проблем общемирового здравоохранения. Неуклонный рост заболеваемости, формирование осложнений и коморбидных состояний, инвалидизация и увеличение смертности у пациентов с ожирением указывают на необходимость разработки новых методов лечения и профилактики данного заболевания. Доказано, что некоторые пробиотические препараты способствуют снижению массы тела. В обзоре представлен анализ данных современных отечественных и зарубежных исследований, касающихся применения определенных штаммов бактерий у лиц с ожирением и избыточной массой тела с превентивной и терапевтической целями. Рассмотрены как «классические» анорексигенные микроорганизмы (Bifidobacterium spp., Lactobacillus spp., Saccharomyces boulardii), так и пробиотики «следующего» поколения (Akkermansia muciniphila, Enterococcus spp., Faecalibacterium prausnitzii, Bacteroides spp., Streptococcus spp., Еubacterium rectale, Blautia spp., Christensenella minuta). Описаны основные патогенетические аспекты снижения массы тела при применении указанных пробиотических препаратов (уменьшение проницаемости и усиление защитных функций кишечного эпителия, воздействие на микробиом пищеварительной системы, проявление противовоспалительной активности).

In recent decades, obesity and overweight have become one of the significant problems of global public health. The steady growth of morbidity, development of complications and comorbid conditions, disability and an increase in mortality in obese patients indicate the need to develop new methods of treatment and prevention of this disease. It has been proven that some probiotics contribute to weight loss. The review presents an analysis of data from modern domestic and foreign studies concerning the use of certain bacterial strains in obese and overweight people for preventive and therapeutic purposes. Both classic probiotics with anorexigenic effect (Bifidobacterium spp., Lactobacillus spp., Saccharomyces boulardii) and next-generation ones (Akkermansia muciniphila, Enterococcus spp., Faecalibacterium prausnitzii, Bacteroides spp., Streptococcus spp., Eubacterium rectale, Blautia spp., Christensenella minuta) are considered. The main pathogenetic aspects of weight loss when using these probiotics (reduced permeability and enhanced protective functions of the intestinal epithelium, effects on the gut microbiome, anti-inflammatory activity) are described.

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The authors declare that there are no conflicts of interest present.