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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2025-9-2-112-125</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-1202</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Причины возрастной алопеции с точки зрения современной морфологии</article-title><trans-title-group xml:lang="en"><trans-title>The causes of age-related alopecia from the point of view of modern morphology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3152-8380</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баландин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balandin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баландин Анатолий Александрович – д-р мед. наук, доцент кафедры нормальной, топографической и клинической анатомии, оперативной хирургии</p><p>614990, г. Пермь, ул. Петропавловская, 26</p></bio><bio xml:lang="en"><p>Anatolii A. Balandin – Dr. Sci. (Med.), Associate Professor, Department of Normal, Topographic and Clinical Anatomy, Operative Surgery</p><p>26, Petropavlovskaya str., Perm, 614990</p></bio><email xlink:type="simple">balandinnauka@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-6629-5541</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тиунова</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tiunova</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тиунова Валенсия Васильевна – аспирант кафедры нормальной, топографической и клинической анатомии, оперативной хирургии</p><p>614990, г. Пермь, ул. Петропавловская, 26</p></bio><bio xml:lang="en"><p>Valensiya V. Tiunova – Post-graduate Student, Department of Normal, Topographic and Clinical Anatomy, Operative Surgery</p><p>26, Petropavlovskaya str., Perm, 614990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4856-9066</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баландина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balandina</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баландина Ирина Анатольевна – д-р мед. наук, профессор, заведующий кафедрой нормальной, топографической и клинической анатомии, оперативной хирургии</p><p>614990, г. Пермь, ул. Петропавловская, 26</p></bio><bio xml:lang="en"><p>Irina A. Balandina – Dr. Sci. (Med.), Professor, Head, Department of Normal, Topographic and Clinical Anatomy, Operative Surgery</p><p>26, Petropavlovskaya str., Perm, 614990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Пермский государственный медицинский университет им. академика Е.А. Вагнера» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm State Medical University named after Academician E.A. Wagner</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>113</fpage><lpage>126</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баландин А.А., Тиунова В.В., Баландина И.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Баландин А.А., Тиунова В.В., Баландина И.А.</copyright-holder><copyright-holder xml:lang="en">Balandin A.A., Tiunova V.V., Balandina I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/1202">https://jsms.elpub.ru/jour/article/view/1202</self-uri><abstract><p>Старение – процесс, заложенный самой природой, сложный и многокомпонентный, заключающийся в постепенном развитии биологических нарушений, которые системно ослабляют способность организма противостоять стрессовым факторам и способствуют развитию хронических заболеваний. Однако благодаря поступательному развитию медицинских технологий человек не просто может позволить себе минимизировать ущерб от этого процесса, но и выглядеть привлекательным и здоровым даже в почтенном возрасте. В современных реалиях – это более чем достижимая цель. В данном обзоре освещены, на наш взгляд, основные морфологические факторы, приводящие к ухудшению качества прически вследствие возрастной алопеции – инволютивные изменения сосудистого русла и лимфатической системы кожи с изменением ее межклеточного вещества, истощение ниш стволовых клеток волосяных фолликулов, а также рассматривается митохондриальная теория старения. Дальнейшее детальное изучение этих факторов необходимо для понимания тонких клеточных механизмов старения, что позволит их замедлить, а по возможности и полностью нивелировать. Данная стратегия выигрышна в перспективе и может существенно продвинуть такие сферы медицины, как трихология, косметология, гериатрия, а также оказать влияние на тактические подходы фармакологических компаний, занимающихся разработкой лекарственных средств, направленных на профилактику возрастной алопеции. Быть может, спустя время иметь длинные, пышные, а главное, свои волосы в старческом возрасте будет само собой разумеющейся задачей.</p></abstract><trans-abstract xml:lang="en"><p>Aging is an inherent natural process, complex and multicomponent, consisting of the gradual accumulation of biological changes that at the systemic level weaken the body’s ability to resist stress factors, and contribute to the development of chronic diseases. However, thanks to the progressive development of medical technologies, humanity can not only afford to minimize the damage from this process, but also look attractive and healthy even at an advanced age. In the realities of modern life, this is a more than achievable goal. This review highlights, in our opinion, the main morphological factors leading to deterioration in the quality of hair due to age-related alopecia – involutional changes in the vascular bed and the skin lymphatic system with a change in its intercellular substance, depletion of the of stem cell niches of hair follicles, and also the mitochondrial theory of aging is considered. Further detailed study of these factors is necessary to understand the subtle cellular mechanisms of aging, which will slow them down, and, if possible, completely neutralize them. This strategy is profitable over the long term and can significantly advance such areas of medicine as trichology, cosmetology, geriatrics, and also influence the tactical approaches of pharmaceutical companies engaged in the development of drugs for preventing age-related alopecia. Perhaps, after a while, having long, lush, and most importantly, your own hair in old age will be a matter of course.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>волос</kwd><kwd>старение</kwd><kwd>алопеция</kwd><kwd>морфология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hair</kwd><kwd>aging</kwd><kwd>alopecia</kwd><kwd>morphology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Прохоров Л.Ю. Увеличение активной продолжительности жизни пожилых людей за счет применения методов разрабатываемой общей теории омоложения организмов // Клиническая геронтология. 2017;23(9-10):55-56.</mixed-citation><mixed-citation xml:lang="en">Prokhorov L.Yu. Increase active life expectancy of older people through the use of general theory of rejuvenating. Clinical Gerontology. 2017;23(9-10):55-56. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Aburto J.M., Villavicencio F., Basellini U. et al. Dynamics of life expectancy and life span equality // Proc. Natl. Acad. Sci. U S A. 2020;117(10):5250-5259. DOI: 10.1073/pnas.1915884117.</mixed-citation><mixed-citation xml:lang="en">Aburto J.M., Villavicencio F., Basellini U. et al. Dynamics of life expectancy and life span equality. Proc. Natl. Acad. Sci. U S A. 2020;117(10):5250-5259. DOI: 10.1073/pnas.1915884117.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gu J., Ming X. The influence of living conditions on self-rated health: evidence from China // Int. J. Environ. Res. Public Health. 2021;18(17):9200. DOI: 10.3390/ijerph18179200.</mixed-citation><mixed-citation xml:lang="en">Gu J., Ming X. The influence of living conditions on self-rated health: evidence from China. Int. J. Environ. Res. Public Health. 2021;18(17):9200. DOI: 10.3390/ijerph18179200.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Reizine N.M., O'Donnell P.H. Modern developments in germline pharmacogenomics for oncology prescribing // CA Cancer J. Clin. 2022;72(4):315-332. DOI: 10.3322/caac.21722.</mixed-citation><mixed-citation xml:lang="en">Reizine N.M., O’Donnell P.H. Modern developments in germline pharmacogenomics for oncology prescribing. CA Cancer J. Clin. 2022;72(4):315-332. DOI: 10.3322/caac.21722.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Баландин А.А., Железнов Л.М., Баландина И.А. Возрастные изменения в нижней полулунной дольке мозжечка у мужчин // Наука молодых (Eruditio Juvenium). 2020;8(3):337-344. DOI: 10.23888/HMJ202083337-344.</mixed-citation><mixed-citation xml:lang="en">Balandin A.A., Zheleznov L.M., Balandina I.A. Age-related alterations in the inferior semilunar lobule of cerebellum in men. Science of the Young (Eruditio Juvenium). 2020;8(3):337-344. DOI: 10.23888/HMJ202083337-344. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">фон Фингергут Г., Окамото Н., Араки А. и др. Факторы, влияющие на качество сна у пожилых россиян – городских жителей Дальнего Востока России. Роль алкоголя как фактора риска: кросс-секционное исследование // Journal of Siberian Medical Sciences. 2024;8(2):7-20. DOI: 10.31549/2542-1174-2024-8-2-7-20.</mixed-citation><mixed-citation xml:lang="en">von Fingerhut G., Okamoto N., Araki A. et al. Factors related to sleep quality among community-dwelling Russian older people in the Far East. The role of alcohol as a risk factor: a cross-sectional study. Journal of Siberian Medical Sciences. 2024;8(2):7-20. DOI: 10.31549/2542-1174-2024-8-2-7-20.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wleklik M., Uchmanowicz I., Jankowska-Polańska B. et al. The role of nutritional status in elderly patients with heart failure // J. Nutr. Health Aging. 2018;22(5):581-588. DOI: 10.1007/s12603-017-0985-1.</mixed-citation><mixed-citation xml:lang="en">Wleklik M., Uchmanowicz I., Jankowska-Polańska B. et al. The role of nutritional status in elderly patients with heart failure. J. Nutr. Health Aging. 2018;22(5):581-588. DOI: 10.1007/s12603-017-0985-1.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pisanti S., Mencherini T., Esposito T. et al. The medieval skincare routine according to the formulations of Madgistra Trotula and the Medical School of Salerno and its reflection on cosmetology of the third millennium // J. Cosmet. Dermatol. 2023;22(2):542-554. DOI: 10.1111/jocd.15234.</mixed-citation><mixed-citation xml:lang="en">Pisanti S., Mencherini T., Esposito T. et al. The medieval skincare routine according to the formulations of Madgistra Trotula and the Medical School of Salerno and its reflection on cosmetology of the third millennium. J. Cosmet. Dermatol. 2023;22(2):542-554. DOI: 10.1111/jocd.15234.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ермолаева Е.В., Эминова Б.Я., Джагутханова Т.Б. Развитие косметологии в России // Бюллетень медицинских интернет-конференций. 2016;6(1):99.</mixed-citation><mixed-citation xml:lang="en">Ermolaeva E.V., Eminova B.Ya., Dzhagutkhanova T.B. Development of cosmetology in Russia. Bulletin of Medical Internet Conferences. 2016;6(1):99. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cтoчик А.А. Из истории становления косметологии в России. Первый московский институт врачебной косметики // Бюллетень Национального научно-исследовательского института общественного здоровья имени Н.А. Семашко. 2019;3-4:88-95. DOI: 10.25742/NRIPH.2019.03.010.</mixed-citation><mixed-citation xml:lang="en">Stochik A.A. From the history of formation of cosmetology in Russia. First Moscow institute of medical cosmetics. Bulletin of Semashko National Research Institute of Public Health. 2019;3-4:88-95. DOI: 10.25742/NRIPH.2019.03.010. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Trüeb R.M., Rezende H.D., Dias M.F.R.G., Uribe N.C. Trichology and trichiatry; etymological and terminological considerations // Int. J. Trichology. 2022;14(4):117-119. DOI: 10.4103/ijt.ijt_104_21.</mixed-citation><mixed-citation xml:lang="en">Trüeb R.M., Rezende H.D., Dias M.F.R.G., Uribe N.C. Trichology and trichiatry; etymological and terminological considerations. Int. J. Trichology. 2022;14(4):117-119. DOI: 10.4103/ijt.ijt_104_21.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Trüeb R.M., Dutra H., Dias M.F.R.G. Autistic-undisciplined thinking in the practice of medical trichology // Int. J. Trichology. 2019;11(1):1-7. DOI: 10.4103/ijt.ijt_79_18.</mixed-citation><mixed-citation xml:lang="en">Trüeb R.M., Dutra H., Dias M.F.R.G. Autistic-undisciplined thinking in the practice of medical trichology. Int. J. Trichology. 2019;11(1):1-7. DOI: 10.4103/ijt.ijt_79_18.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Светличная И.В. Влияние стиля прически на процессы коммуникации // Общество: философия, история, культура. 2018;11(55):156-163. DOI: 10.24158/fik.2018.11.29.</mixed-citation><mixed-citation xml:lang="en">Svetlichnaya I.V. The impact of hairstyle on communication process. Society: Philosophy, History, Culture. 2018;11(55):156-163. DOI: 10.24158/fik.2018.11.29. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Sinclair R.D. Healthy hair: what is it // J. Investig. Dermatol. Symp. Proc. 2007;12(2):2-5. DOI: 10.1038/sj.jidsymp.5650046.</mixed-citation><mixed-citation xml:lang="en">Sinclair R.D. Healthy hair: what is it // J. Investig. Dermatol. Symp. Proc. 2007;12(2):2-5. DOI: 10.1038/sj.jidsymp.5650046.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider M.R., Schmidt-Ullrich R., Paus R. The hair follicle as a dynamic miniorgan // Curr. Biol. 2009;19(3):R132-142. DOI: 10.1016/j.cub.2008.12.005.</mixed-citation><mixed-citation xml:lang="en">Schneider M.R., Schmidt-Ullrich R., Paus R. The hair follicle as a dynamic miniorgan // Curr. Biol. 2009;19(3):R132-142. DOI: 10.1016/j.cub.2008.12.005.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Slominski A., Wortsman J., Plonka P.M. et al. Hair follicle pigmentation // J. Invest. Dermatol. 2005;124(1):13-21. DOI: 10.1111/j.0022-202X.2004.23528.x.</mixed-citation><mixed-citation xml:lang="en">Slominski A., Wortsman J., Plonka P.M. et al. Hair follicle pigmentation // J. Invest. Dermatol. 2005;124(1):13-21. DOI: 10.1111/j.0022-202X.2004.23528.x.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cao W., Mao H., McCallum N.C. et al. Biomimetic pheomelanin to unravel the electronic, molecular and supramolecular structure of the natural product // Chem. Sci. 2023;31;14(15):4183-4192. DOI: 10.1039/d2sc06418a.</mixed-citation><mixed-citation xml:lang="en">Cao W., Mao H., McCallum N.C. et al. Biomimetic pheomelanin to unravel the electronic, molecular and supramolecular structure of the natural product // Chem. Sci. 2023;31;14(15):4183-4192. DOI: 10.1039/d2sc06418a.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Feng Z., Qin Y., Jiang G. Reversing gray hair: inspiring the development of new therapies through research on hair pigmentation and repigmentation progress // Int. J. Biol. Sci. 2023;19(14):4588-4607. DOI: 10.7150/ijbs.86911.</mixed-citation><mixed-citation xml:lang="en">Feng Z., Qin Y., Jiang G. Reversing gray hair: inspiring the development of new therapies through research on hair pigmentation and repigmentation progress // Int. J. Biol. Sci. 2023;19(14):4588-4607. DOI: 10.7150/ijbs.86911.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kato H., Kinoshita K., Saito N. et al. The effects of ischemia and hyperoxygenation on hair growth and cycle // Organogenesis. 2020;16(3):83-94. DOI: 10.1080/15476278.2020.1794271.</mixed-citation><mixed-citation xml:lang="en">Kato H., Kinoshita K., Saito N. et al. The effects of ischemia and hyperoxygenation on hair growth and cycle // Organogenesis. 2020;16(3):83-94. DOI: 10.1080/15476278.2020.1794271.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ryan T. The ageing of the blood supply and the lymphatic drainage of the skin // Micron. 2004;35(3):161-171. DOI: 10.1016/j.micron.2003.11.010.</mixed-citation><mixed-citation xml:lang="en">Ryan T. The ageing of the blood supply and the lymphatic drainage of the skin // Micron. 2004;35(3):161-171. DOI: 10.1016/j.micron.2003.11.010.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Cracowski J.L., Roustit M. Human skin microcirculation // Compr. Physiol. 2020;10(3):1105-1154. DOI: 10.1002/cphy.c190008.</mixed-citation><mixed-citation xml:lang="en">Cracowski J.L., Roustit M. Human skin microcirculation // Compr. Physiol. 2020;10(3):1105-1154. DOI: 10.1002/cphy.c190008.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Młodziński K., Świątczak M., Rohun J. et al. Vascular aging and damage in patients with iron metabolism disorders // Diagnostics (Basel). 2022;12(11):2817. DOI: 10.3390/diagnostics12112817.</mixed-citation><mixed-citation xml:lang="en">Młodziński K., Świątczak M., Rohun J. et al. Vascular aging and damage in patients with iron metabolism disorders // Diagnostics (Basel). 2022;12(11):2817. DOI: 10.3390/diagnostics12112817.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Власова Т.И., Петрищев Н.Н., Власов Т.Д. Эндотелий и старение: механизмы формирования сенесцентного фенотипа эндотелиальных клеток // Регионарное кровообращение и микроциркуляция. 2023;22(3(87)):19-33. DOI: 10.24884/1682-6655-2023-22-3-19-33.</mixed-citation><mixed-citation xml:lang="en">Vlasova T.I., Petrishchev N.N., Vlasov T.D. Endothelium and aging: mechanisms for formation of senescence associated phenotype of endothelial cells. Regional Blood Circulation and Microcirculation. 2023;22(3(87)):19-33. DOI: 10.24884/1682-6655-2023-22-3-19-33.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kataru R.P., Park H.J., Shin J. et al. Structural and functional changes in aged skin lymphatic vessels // Front. Aging. 2022;3:864860. DOI: 10.3389/fragi.2022.864860.</mixed-citation><mixed-citation xml:lang="en">Kataru R.P., Park H.J., Shin J. et al. Structural and functional changes in aged skin lymphatic vessels // Front. Aging. 2022;3:864860. DOI: 10.3389/fragi.2022.864860.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Quaresma J.A.S. Organization of the skin immune system and compartmentalized immune responses in infectious diseases // Clin. Microbiol. Rev. 2019;32(4):e00034-18. DOI: 10.1128/CMR.00034-18.</mixed-citation><mixed-citation xml:lang="en">Quaresma J.A.S. Organization of the skin immune system and compartmentalized immune responses in infectious diseases // Clin. Microbiol. Rev. 2019;32(4):e00034-18. DOI: 10.1128/CMR.00034-18.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Skobe M., Detmar M. Structure, function, and molecular control of the skin lymphatic system // J. Investig. Dermatol. Symp. Proc. 2000;5(1):14-19. DOI: 10.1046/j.1087-0024.2000.00001.x.</mixed-citation><mixed-citation xml:lang="en">Skobe M., Detmar M. Structure, function, and molecular control of the skin lymphatic system // J. Investig. Dermatol. Symp. Proc. 2000;5(1):14-19. DOI: 10.1046/j.1087-0024.2000.00001.x.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Raja E., Clarin M.T.R.D.C., Yanagisawa H. Matricellular proteins in the homeostasis, regeneration, and aging of skin // Int. J. Mol. Sci. 2023;24(18):14274. DOI: 10.3390/ijms241814274.</mixed-citation><mixed-citation xml:lang="en">Raja E., Clarin M.T.R.D.C., Yanagisawa H. Matricellular proteins in the homeostasis, regeneration, and aging of skin // Int. J. Mol. Sci. 2023;24(18):14274. DOI: 10.3390/ijms241814274.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cárdenas-León C.G., Mäemets-Allas K., Klaas M. et al. Matricellular proteins in cutaneous wound healing // Front. Cell Dev. Biol. 2022;10:1073320. DOI: 10.3389/fcell.2022.1073320.</mixed-citation><mixed-citation xml:lang="en">Cárdenas-León C.G., Mäemets-Allas K., Klaas M. et al. Matricellular proteins in cutaneous wound healing // Front. Cell Dev. Biol. 2022;10:1073320. DOI: 10.3389/fcell.2022.1073320.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang M., Pal A., Lyu X. et al. Artificial-goosebump-driven microactuation // Nat. Mater. 2024;23(4):560-569. DOI: 10.1038/s41563-024-01810-6.</mixed-citation><mixed-citation xml:lang="en">Zhang M., Pal A., Lyu X. et al. Artificial-goosebump-driven microactuation // Nat. Mater. 2024;23(4):560-569. DOI: 10.1038/s41563-024-01810-6.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Jang H., Jo Y., Lee J.H., Choi S. Aging of hair follicle stem cells and their niches // BMB Rep. 2023;56(1):2-9. DOI: 10.5483/BMBRep.2022-0183.</mixed-citation><mixed-citation xml:lang="en">Jang H., Jo Y., Lee J.H., Choi S. Aging of hair follicle stem cells and their niches // BMB Rep. 2023;56(1):2-9. DOI: 10.5483/BMBRep.2022-0183.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Kolios G., Moodley Y. Introduction to stem cells and regenerative medicine // Respiration. 2013;85(1):3-10. DOI: 10.1159/000345615.</mixed-citation><mixed-citation xml:lang="en">Kolios G., Moodley Y. Introduction to stem cells and regenerative medicine // Respiration. 2013;85(1):3-10. DOI: 10.1159/000345615.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell // Blood Cells. 1978;4(1-2):7-25.</mixed-citation><mixed-citation xml:lang="en">Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell // Blood Cells. 1978;4(1-2):7-25.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Li K.N., Tumbar T. Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis // EMBO J. 2021;40(11):e107135. DOI: 10.15252/embj.2020107135.</mixed-citation><mixed-citation xml:lang="en">Li K.N., Tumbar T. Hair follicle stem cells as a skin-organizing signaling center during adult homeostasis // EMBO J. 2021;40(11):e107135. DOI: 10.15252/embj.2020107135.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Баландин А.А., Юдина В.В., Баландина И.А. и др. Морфологические изменения волосяной луковицы и стержня волоса к старческому возрасту // Успехи геронтологии. 2023;36(6):874-877. DOI: 10.34922/AE.2023.36.6.016.</mixed-citation><mixed-citation xml:lang="en">Balandin А.А., Yudina V.V., Balandina I.A. et al. Morphologial changes in the hair follicle and hair shaft in old age. Advances in Gerontology. 2023;36(6):874-877. DOI: 10.34922/AE.2023.36.6.016. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Xie Y., Chen D., Jiang K. et al. Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis // Cell Stem Cell. 2022;29(1):70-85.e6. DOI: 10.1016/j.stem.2021.09.009.</mixed-citation><mixed-citation xml:lang="en">Xie Y., Chen D., Jiang K. et al. Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis. Cell Stem Cell. 2022;29(1):70-85.e6. DOI: 10.1016/j.stem.2021.09.009.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Bratic A., Larsson N.G. The role of mitochondria in aging // J. Clin. Invest. 2013;123(3):951-957. DOI: 10.1172/JCI64125.</mixed-citation><mixed-citation xml:lang="en">Bratic A., Larsson N.G. The role of mitochondria in aging. J. Clin. Invest. 2013;123(3):951-957. DOI: 10.1172/JCI64125.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Легащёва Н.В., Новоточинова А.А. Митохондриальная теория старения // Инновационная наука. 2019;2:149-151.</mixed-citation><mixed-citation xml:lang="en">Legashcheva N.V., Novotochinova A.A. Mitochondrial theory of aging. Innovation Science. 2019;2:149-151. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Harman D. The aging process // Proc. Natl. Acad. Sci. USA. 1981;78(11):7124-7128. DOI: 10.1073/pnas.78.11.7124.</mixed-citation><mixed-citation xml:lang="en">Harman D. The aging process. Proc. Natl. Acad. Sci. U S A. 1981;78(11):7124-7128. DOI: 10.1073/pnas.78.11.7124.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Harman D. Free radical theory of aging // Mutat. Res. 1992;275(3-6):257-266. DOI: 10.1016/0921-8734(92)90030-s.</mixed-citation><mixed-citation xml:lang="en">Harman D. Free radical theory of aging. Mutat. Res. 1992;275(3-6):257-266. DOI: 10.1016/0921-8734(92)90030-s.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Harman D. Aging: overview // Ann. N Y Acad. Sci. 2001;928:1-21. DOI: 10.1111/j.1749-6632.2001.tb05631.x.</mixed-citation><mixed-citation xml:lang="en">Harman D. Aging: overview. Ann. N Y Acad. Sci. 2001;928:1-21. DOI: 10.1111/j.1749-6632.2001.tb05631.x.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Баландин А.А., Тимганова Г.С., Баландина И.А. Гематоэнцефалический барьер на страже молодости головного мозга (лекция) // Регионарное кровообращение и микроциркуляция. 2024;23(2(90)):90-96. DOI: 10.24884/1682-6655-2024-23-2-84-90.</mixed-citation><mixed-citation xml:lang="en">Balandin А.А., Timganova G.S., Balandina I.A. Blood-brain barrier as guardian of brain youth (lecture). Regional Blood Circulation and Microcirculation. 2024;23(2(90)):90-96. DOI: 10.24884/1682-6655-2024-23-2-84-90. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Егорова А.В., Воронков Д.Н., Федорова Е.Н. и др. Особенности строения и функции митохондрий в нейронах и глиоцитах различных отделов головного мозга лабораторных грызунов // Клиническая и экспериментальная морфология. 2023;12(2):5-13. DOI: 10.31088/CEM2023.12.2.5-13.</mixed-citation><mixed-citation xml:lang="en">Egorova A.V., Voronkov D.N., Fedorova E.N. et al. Structural and functional features of mitochondria in neurons and gliocytes of various cerebral regions of laboratory rodents. Clinical and Experimental Morphology. 2023;12(2):5-13. DOI: 10.31088/CEM2023.12.2.5-13. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Yin F., Jiang T., Cadenas E. Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signaling // Biochem. Soc. Trans. 2013;41(1):101-115. DOI: 10.1042/BST20120260.</mixed-citation><mixed-citation xml:lang="en">Yin F., Jiang T., Cadenas E. Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signaling. Biochem. Soc. Trans. 2013;41(1):101-115. DOI: 10.1042/BST20120260.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Singh B., Schoeb T.R., Bajpai P. et al. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function // Cell Death Dis. 2018;9(7):735. DOI: 10.1038/s41419-018-0765-9.</mixed-citation><mixed-citation xml:lang="en">Singh B., Schoeb T.R., Bajpai P. et al. Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function. Cell Death Dis. 2018;9(7):735. DOI: 10.1038/s41419-018-0765-9.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Natarelli N., Gahoonia N., Aflatooni S. et al. Dermatologic manifestations of mitochondrial dysfunction: a review of the literature // Int. J. Mol. Sci. 2024;25(6):3303. DOI: 10.3390/ijms25063303.</mixed-citation><mixed-citation xml:lang="en">Natarelli N., Gahoonia N., Aflatooni S. et al. Dermatologic manifestations of mitochondrial dysfunction: a review of the literature. Int. J. Mol. Sci. 2024;25(6):3303. DOI: 10.3390/ijms25063303.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Csekes E., Račková L. Skin aging, cellular senescence and natural polyphenols // Int. J. Mol. Sci. 2021;22(23):12641. DOI: 10.3390/ijms222312641.</mixed-citation><mixed-citation xml:lang="en">Csekes E., Račková L. Skin aging, cellular senescence and natural polyphenols. Int. J. Mol. Sci. 2021;22(23):12641. DOI: 10.3390/ijms222312641.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
