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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-124</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.01.00 КЛИНИЧЕСКАЯ МЕДИЦИНА)</subject></subj-group></article-categories><title-group><article-title>ИЗМЕНЕНИЕ УРОВНЯ МОЧЕВОЙ КИСЛОТЫ У БОЛЬНЫХ ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК</article-title><trans-title-group xml:lang="en"><trans-title>CHANGE OF LEVEL OF URINARY ACID AT PATIENTS WITH CHRONIC RENAL DISEASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>Т. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>T. O.</given-names></name></name-alternatives><email xlink:type="simple">Rudenko060890@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Худякова</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Khudyakova</surname><given-names>A. D.</given-names></name></name-alternatives><email xlink:type="simple">alene-elene@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суворова</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Suvorova</surname><given-names>T. S.</given-names></name></name-alternatives><email xlink:type="simple">suvortan2000@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SBEI HPE «Novosibirsk State Medical University of Ministry of Health»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>04</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>3</issue><fpage>33</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Руденко Т.О., Худякова А.Д., Суворова Т.С., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Руденко Т.О., Худякова А.Д., Суворова Т.С.</copyright-holder><copyright-holder xml:lang="en">Rudenko T.O., Khudyakova A.D., Suvorova T.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/124">https://jsms.elpub.ru/jour/article/view/124</self-uri><abstract><p>С целью изучения роли гиперурикемии как независимого фактора риска развития и прогрессирования хронической болезни почек проанализировано 947 историй болезни пациентов с данной патологией, находившихся на стационарном лечении (мужчин - 552, женщин - 395, средний возраст 46 ± 29 лет). Проведена оценка уровня мочевой кислоты, изучена корреляционная зависимость уровня гиперурикемии от возраста больных, стадии заболевания, наличия артериальной гипертензии и альбуминурии. Наиболее значимая гиперурикемия выявлена у больных с терминальной стадией хронической болезни почек. Сделаны выводы о возможности использования гиперурикемии как дополнительного маркера прогрессирования хронической болезни почек наряду с альбуминурией, а также о вероятной роли препаратов, снижающих уровень мочевой кислоты, в замедлении темпов прогрессирования хронической болезни почек.</p></abstract><trans-abstract xml:lang="en"><p>947 case records of the patients with this pathology who were hospitalized are analysed (men - 552, women - 395, middle age is 46 ± 29 years) for the purpose of studying of hyperuricemia as independent risk factor of development of chronic renal disease. The assessment of level of urinary acid is carried out, correlation of influence of hyperuricemia level on age of patients, stages of disease, existence of arterial hypertension and albuminuria is studied. The most significant hyperuricemia is registered at patients with an end-stage of chronic renal disease. There were concluded about possibilityof usage of hyperuricemia as additional marker of progress of chronic renal disease along with albuminuria, and also about probable role of the medicines reducing the level of urinary acid in retardation of progressing rates of chronic renal disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>гиперурикемия</kwd><kwd>артериальная гипертензия</kwd><kwd>фактор риска</kwd><kwd>маркер прогрессирования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic renal disease</kwd><kwd>hyperuricemia</kwd><kwd>arterial hypertension</kwd><kwd>risk factor</kwd><kwd>advance marker</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Нефрология. Национальное руководство / Под ред. Н. А. Мухина. - М. : ГЭОТАР?Медиа, 2009. - 720 с.</mixed-citation><mixed-citation xml:lang="en">Нефрология. 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