jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)10.31549/2542-1174-2025-9-4-121-132jsms-1281Research ArticleОБЗОРЫREVIEWРоль ожирения в патогенезе миомы маткиThe role of obesity in the pathogenesis of uterine leiomyomahttps://orcid.org/0000-0001-9694-8274БабичевВ. К.BabichevV. K.

Бабичев Валентин Константинович – аспирант  кафедры акушерства и гинекологии

 630091, г. Новосибирск, Красный просп., 52.

Valentin K. Babichev – Post-Graduate Student, Department of Obstetrics and Gynecology 

Novosibirsk

vkbabichev@gmail.comhttps://orcid.org/0000-0003-2205-3982ПивеньЛ. А.PivenL. A.

Пивень Людмила Анатольевна – канд. мед. наук, доцент кафедры акушерства и гинекологии

Новосибирск

Ludlmila A. Piven – Cand. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology

 Novosibirsk

https://orcid.org/0000-0001-6029-8791КучеренкоС. Г.KucherenkoS. G.

Кучеренко Светлана Геннадиевна – канд. мед. наук, доцент кафедры акушерства и гинекологии

Новосибирск

Svetlana G. Kucherenko – Cand. Sci. (Med.), Associate Professor, Department of Obstetrics and Gynecology

Novosibirsk 

https://orcid.org/0000-0002-4378-7945КиселеваТ. В.KiselevaТ. V.

Киселева Татьяна Вячеславовна – д-р мед. наук, профессор кафедры акушерства и гинекологии  Новосибирск

Тatiana V. Kiseleva – Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology

 Novosibirsk

https://orcid.org/0000-0003-3284-9810ХаятоваЗ. Б.KhayatovaZ. B.

Хаятова Зульфия Базарбековна – д-р мед. наук, профессор кафедры акушерства и гинекологии Новосибирск

Zulfiya B. Khayatova – Dr. Sci. (Med.), Professor, Department of Obstetrics and Gynecology

Novosibirsk 

https://orcid.org/0000-0002-9409-4823МаринкинИ. О.MarinkinI. O.

Маринкин Игорь Олегович – д-р мед. наук, профессор, заведующий кафедрой акушерства и гинекологии

Новосибирск

Igor O. Marinkin – Dr. Sci. (Med.), Professor, Head, Department of Obstetrics and Gynecology

 Novosibirsk 

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииРоссияNovosibirsk State Medical UniversityRussian Federation20252612202504121132Copyright © Бабичев В.К., Пивень Л.А., Кучеренко С.Г., Киселева Т.В., Хаятова З.Б., Маринкин И.О., 20252025Бабичев В.К., Пивень Л.А., Кучеренко С.Г., Киселева Т.В., Хаятова З.Б., Маринкин И.О.Babichev V.K., Piven L.A., Kucherenko S.G., Kiseleva Т.V., Khayatova Z.B., Marinkin I.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/1281

Миома матки представляет собой самую распространенную доброкачественную моноклональную опухоль у гинекологических пациенток. Данное заболевание имеет высокую социальную и экономическую значимость, снижая качество жизни, трудоспособность и репродуктивный потенциал в женской популяции, являясь наиболее частой причиной гистерэктомии в мире. В настоящее время проводится поиск новых факторов, влияющих на возникновение и рост миоматозных узлов. Вместе с тем патогенез миомы матки и полный спектр возможных причин различного течения опухолевого роста остается невыясненным. В последние годы все больше исследований указывают на значимую роль жировой ткани и продуцирумых ею адипокинов в развитии миоматозных узлов. Особенно важным поиск подобных корреляций становится в условиях эпидемии ожирения в развитых странах. Настоящий обзор суммирует данные существующих исследований, представленных на платформах PubMed, Scopus, eLIBRARY, CyberLeninka, в которых изучалось влияние ожирения на образование новых и рост существующих миоматозных узлов.

Uterine fibroids are the most common benign monoclonal tumors in gynecological patients. This disease has a high social and economic significance, as it reduces quality of life, work capacity, and reproductive potential in women, and is the most common cause of hysterectomy worldwide. Currently, ongoing research is aimed at identifying new factors influencing the tumorigenesis and growth of fibroid nodules. However, the pathogenesis of uterine fibroids and the full range of causes underlying the variability in tumor growth remain insufficiently understood. In recent years, increasing evidence has highlighted the significant role of adipose tissue and the adipokines it produces in the development of uterine fibroids. The search for such correlations is particularly relevant in the context of the obesity epidemic in developed countries. In this context, we reviewed existing studies available on platforms such as PubMed, Scopus, eLIBRARY, and Cyberleninka, which reflect current understanding of the influence of obesity on the formation and growth of uterine fibroids.

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The authors declare that there are no conflicts of interest present.