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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-133</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.01.00 КЛИНИЧЕСКАЯ МЕДИЦИНА)</subject></subj-group></article-categories><title-group><article-title>ВАЗОАКТИВНЫЙ ЭФФЕКТ РОПИВОКАИНА ПРИ БЛОКАДЕ СЕДАЛИЩНОГО НЕРВА У БОЛЬНЫХ С ДИАБЕТИЧЕСКОЙ СТОПОЙ</article-title><trans-title-group xml:lang="en"><trans-title>VASOACTIVE EFFECT OF ROPIVOCAINE AT SCIATIC NERVE BLOCKADE AT PATIENTS WITH DIABETIC FOOT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Флягин</surname><given-names>Т. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Flyagin</surname><given-names>T. S.</given-names></name></name-alternatives><email xlink:type="simple">yel_dragon@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кохно</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kokhno</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">kair2007@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Локтин</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Loktin</surname><given-names>E. M.</given-names></name></name-alternatives><email xlink:type="simple">yel_dragon@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ НСО «Городская клиническая больница № 2»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>MBHE «City clinical hospital № 2»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБОУ ВПО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SBEI HPE «Novosibirsk State Medical University of Ministry of Health»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>04</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>3</issue><fpage>42</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Флягин Т.С., Кохно В.Н., Локтин Е.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Флягин Т.С., Кохно В.Н., Локтин Е.М.</copyright-holder><copyright-holder xml:lang="en">Flyagin T.S., Kokhno V.N., Loktin E.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/133">https://jsms.elpub.ru/jour/article/view/133</self-uri><abstract><p>Цель: исследование вазоактивных свойств Ропивакаина при использовании пролонгированной блокады седалищного нерва. Материалы и методы. В проспективное исследование включено 107 больных с синдромом диабетической стопы. В течение 10-ти суток велось наблюдение за показателями плече-лодыжечного индекса (ПЛИ), пресепсина, фибробластов в мазках-отпечатках, концентрации Ропивакаина. Результаты. У пациентов, получавших пролонгированную блокаду, отмечается увеличение показателей ПЛИ (p &lt; 0,05), ускорение выведения пресепсина, интенсификация роста фибробластов. Эффект сохранялся после удаления катетера.</p></abstract><trans-abstract xml:lang="en"><p>Purpose : research of vasoactive properties of Ropivocaine when using of prolonged blockade of sciatic nerve. Materials and methods . Prospective research included 107 patients with a syndrome of diabetic foot. Indicators of brachium- malleolar index (BMI), presepcine, fibroblasts in smears prints, Ropivocaine concentration were observed within 10 days. Results . The augmentation of BMI indicators (p &lt; 0,05), acceleration of presepcine removal, intensification of fibroblasts growth are registered at he patients receiving the prolonged blockade. The effect remained after excision of catheter.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром диабетической стопы</kwd><kwd>пролонгированная анестезия седалищного нерва</kwd><kwd>плече-лодыжечный индекс</kwd><kwd>пресепсин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>syndrome of diabetic foot</kwd><kwd>prolonged anesthesia of sciatic nerve</kwd><kwd>a brachium-malleolar index</kwd><kwd>presepcine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Болонкин Л. С. Особенности анестезиологического обеспечения и интенсивной терапии пациента, страдающего сахарным диабетом / Л. С. Болонкин // Журн. 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