jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-274Research Article14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.01.00 КЛИНИЧЕСКАЯ МЕДИЦИНА)ФАКТОР РОСТА ЭНДОТЕЛИЯ СОСУДОВ: БИОЛОГИЧЕСКИЕ СВОЙСТВА И ПРАКТИЧЕСКОЕ ЗНАЧЕНИЕ (ОБЗОР ЛИТЕРАТУРЫ)GROWTH PROMOTING FACTOR OF ENDOTHELIUM OF VESSELS: BIOLOGICAL PROPERTIES AND PRACTICAL VALUE (LITERATURE REVIEW)СветозарскийН. Л.SvetozarskiyN. L.svetozarskij@rambler.ruАртифексоваА. А.ArtifeksovaA. A.artifeksova@yandex.ruСветозарскийС. Н.SvetozarskiyS. N.svetozarskij@rambler.ruГБУЗ «Нижегородская областная клиническая больница им. Н.А. Семашко»РоссияSBHE «Nizhny Novgorod regional hospital n. a. N. A. Semashko»Russian FederationГБУЗ НО «Медицинский информационно-аналитический центр»РоссияSBHE NR «Medical information and analysis center»Russian FederationФБУЗ «Приволжский окружной медицинский центр» Федерального медико-биологического агентстваРоссияFBHE «Privolzhsky regional medical center» Federal Medical Biological AgencyRussian Federation201504062018052424Copyright © Светозарский Н.Л., Артифексова А.А., Светозарский С.Н., 20182018Светозарский Н.Л., Артифексова А.А., Светозарский С.Н.Svetozarskiy N.L., Artifeksova A.A., Svetozarskiy S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/274

В обзоре литературы представлены основные сведения о факторе роста эндотелия сосудов (vascular endothelial growth factor, VEGF) и сферах его клинического применения. Рассмотрены физиологические и патологические пути образования сосудов и факторы регуляции ангиогенеза. Описаны основные свойства VEGF и его рецепторов, их роль в регуляции сосудистого роста в норме и при развитии злокачественных новообразований и заболеваний сетчатки. Обобщены сведения о препаратах, ингибирующих VEGF-опосредованный ангиогенез. Указано несколько направлений дальнейшего развития антиангиогенной терапии.

The main data on growth promoting factor of endothelium of vessels are presented in the literature review (vascular endothelial growth factor, VEGF) and spheres of its clinical application. Physiological and pathological methods of vessels formation and factors of angiogenesis regulation are considered in the article. The main VEGF properties and its receptors, their role in regulation of vascular growth in norm are described and at development of malignant neoplasms and retina diseases. Data on the preparations inhibiting the VEGF-mediated angiogenesis are generalized. Some directions of further development of anti-angiogenic therapy are specified.

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The authors declare that there are no conflicts of interest present.