jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-298Research Article14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.03.00 МЕДИКО-БИОЛОГИЧЕСКИЕ НАУКИ)ИССЛЕДОВАНИЕ ФАРМАКОКИНЕТИКИ НОВОЙ ФОРМУЛЯЦИИ ДИИНДОЛИЛМЕТАНА НА ПАЦИЕНТКАХ С ГИПЕРПЛАЗИЕЙ ЭНДОМЕТРИЯRESEARCH ON PHARMACOKINETICS OF NEW FORMULIZATION OF DIINDOLYLMETHANE AT PATIENTS WITH HYPERPLASIA OF ENDOMETRIUMДрухВ. М.DrukhV. M.DruhVM@ilmixgroup.ruПальцевМ. А.PaltsevM. A.mpaltzev@gmail.comКузнецовИ. Н.KuznetsovI. N.Kuznetsovin@ilmixgroup.ruАндриановаЕ. А.AndrianovaE. A.AndrianovaEA@ilmixgroup.ruБарановскийП. М.BaranovskyP. M.pbaranovsky@ya.ruФГАОУ ВО «Российский университет дружбы народов»РоссияFSAEE HE «Peoples’ Friendship University of Russia»Russian FederationФГБУ «Российская академия наук»РоссияFSBE «Russian Academy of Science»Russian FederationГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»РоссияSBEI HPE «Moscow state medical stomatological university n. a. A. I. Evdokimov» of Ministry of HealthRussian FederationЗАО «ИльмиксГрупп»РоссияJSC «IlmixGroup»Russian FederationНИЦ «Курчатовский институт»РоссияSRC «The Kurchatov Institute»Russian Federation201504062018054848Copyright © Друх В.М., Пальцев М.А., Кузнецов И.Н., Андрианова Е.А., Барановский П.М., 20182018Друх В.М., Пальцев М.А., Кузнецов И.Н., Андрианова Е.А., Барановский П.М.Drukh V.M., Paltsev M.A., Kuznetsov I.N., Andrianova E.A., Baranovsky P.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/298

Изучена фармакокинетика новой формуляции «Цинетон» на основе действующего вещества 3,3’-дииндолилметан (DIM), содержащей плюроник, у 5-ти пациенток с гиперплазией эндометрия без атипии. Концентрацию DIM в плазме крови определяли методом высокоэффективной жидкостной хроматографии с УФ-детектированием после однократного перорального приема препарата в дозе 300 мг DIM. Средняя величина AUC составила 343,9 ± 112,9 нг·ч/мл, средняя максимальная концентрация (Cmax) DIM в плазме крови - 121,5 ± 38,7 нг/мл, среднее время достижения Cmax - 2,2 ± 0,45 ч. Установлено, что вещество DIM определяется в плазме крови пациенток на протяжении 10 часов после однократного введения препарата, рассчитанное среднее время удержания препарата в системном кровотоке (MRT0inf) составило 4,4 ± 1,35 ч. Период полувыведения (T1/2) составил 1,9 ± 1,6 ч. Полученные результаты подтвердили высокую биодоступность препарата «Цинетон».

The pharmacokinetics of new formulization Cineton on the basis of active ingredient 33,3’-diindolylmethane (DIM) containing pluronic is studied, 5 patients with hyperplasia have endometrium without atypia. DIM concentration in blood plasma was determined by method of a highly effective liquid chromatography with UF-detecting after single oral administration of preparation in a dose of 300 mg of DIM. The average AUC size made 343,9 ± 112,9 ng h/ml, average maximum concentration (Cmax) of DIM in blood plasma - 121,5 ± 38,7 ng/ml, average time of achievement of Cmax - 2,2 ± 0,45 h. It is established that the DIM substance is defined in blood plasma of patients during 10 hours after single introduction of preparation, calculated average time of deduction of preparation in systemic blood flow (MRT0inf) made 4,4 ± 1,35 h. The period of semi-removal (T1/2) made 1,9 ± 1,6 h. The received results confirmed high bioavailability of Cineton preparation.

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The authors declare that there are no conflicts of interest present.