<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-327</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>14.00.00 МЕДИЦИНСКИЕ НАУКИ (14.01.00 КЛИНИЧЕСКАЯ МЕДИЦИНА)</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ СПЕРМАТОПРОТЕКТИВНОЙ ТЕРАПИИ НА ПОКАЗАТЕЛИ ЭЯКУЛЯТА У БОЛЬНЫХ ТУБЕРКУЛЕЗОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ</article-title><trans-title-group xml:lang="en"><trans-title>INFLUENCE OF SPERMATOPROTECTIVE THERAPY ON EJACULATE INDICATORS AT PATIENTS WITH PROSTATIC TUBERCULOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кульчавеня</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulchavenya</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">urotub@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осадчий</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Osadchy</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">urotub@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Новосибирский НИИ туберкулёза» Минздрава России; ГБОУ ВПО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FBHE «Novosibirsk SRI of tuberculosis» of Ministry of Health; SBEI HPE «Novosibirsk State Medical University of Ministry of Health»</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «Новосибирский НИИ туберкулёза» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FBHE «Novosibirsk SRI of tuberculosis» of Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>04</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>6</issue><fpage>21</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кульчавеня Е.В., Осадчий А.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Кульчавеня Е.В., Осадчий А.В.</copyright-holder><copyright-holder xml:lang="en">Kulchavenya E.V., Osadchy A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/327">https://jsms.elpub.ru/jour/article/view/327</self-uri><abstract><p>С целью разработки, апробирования способа восстановления фертильности больных туберкулезом предстательной железы и оценки его эффективности было проведено открытое проспективное сравнительное рандомизированное исследование, в которое включили 72 больных туберкулезом предстательной железы (ТПЖ). Пациенты были распределены в 2 группы: основную (49 человек), в которой получали стандартное этиотропное лечение в комплексе со сперматопротективной терапией, включавшей Селцинк плюс и хорионический гонадотропин, и группу сравнения (23 человека), в которой получали только этиотропное лечение. Проведение сперматопротективной терапии больным ТПЖ увеличило количество сперматозоидов на 44,0 %; увеличило число активно-подвижных форм сперматозоидов (группы А и В) на 22,4 %, повысило количество нормальных форм спермиев на 16,1 %.</p></abstract><trans-abstract xml:lang="en"><p>An open prospective comparative randomized research on 72 patients with prostatic tuberculosis (PT) was conducted for the purpose of development, approbation of method of restoration of fecundity of patients with prostatic tuberculosis and assessment of its efficiency. Patients were divided into 2 groups: the main (49 people) received standard etiotropic treatment in a complex with spermatoprotective therapy including Selzink plus and chorionic Gonadotropinum; and group of comparison (23 persons) received only etiotropic treatment. Carrying out spermatoprotective therapy at patients with PT enlarged quantity of spermatozoons by 44,0 %; enlarged number of active and mobile forms of spermatozoons (group A and B) by 22,4 %, increased quantity of normal forms of sperms by 16,1 %.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулез предстательной железы</kwd><kwd>химиотерапия</kwd><kwd>селен</kwd><kwd>цинк</kwd><kwd>бесплодие</kwd><kwd>спермограмма</kwd><kwd>эякулят</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prostate tuberculosis</kwd><kwd>chemotherapy</kwd><kwd>selenium</kwd><kwd>Zincum</kwd><kwd>sterility</kwd><kwd>spermogram</kwd><kwd>ejaculate</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The efficacy of zinc for treatment of chronic prostatitis / D. Goodarzi [et al.] // Acta Med. Indones. - 2013 Oct. - Vol. 45 (4). - Р. 259-64.</mixed-citation><mixed-citation xml:lang="en">The efficacy of zinc for treatment of chronic prostatitis / D. Goodarzi [et al.] // Acta Med. Indones. - 2013 Oct. - Vol. 45 (4). - Р. 259-64.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кульчавеня Е. В. Простатит. Диагностика и лечение : руководство / Е. В. Кульчавеня, А. И. Неймарк. - М. : ГЭОТАР-Медиа, 2010. - 256 с. - (Библиотека врача-специалиста).</mixed-citation><mixed-citation xml:lang="en">Кульчавеня Е. В. Простатит. Диагностика и лечение : руководство / Е. В. Кульчавеня, А. И. Неймарк. - М. : ГЭОТАР-Медиа, 2010. - 256 с. - (Библиотека врача-специалиста).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Prostatitis syndrome. Changes in the ejaculate and effects on fertility / М. Ludwig [et al.] // Urologe A. - 2001 Jan. - Vol. 40 (1). - Р. 18-23.</mixed-citation><mixed-citation xml:lang="en">Prostatitis syndrome. Changes in the ejaculate and effects on fertility / М. Ludwig [et al.] // Urologe A. - 2001 Jan. - Vol. 40 (1). - Р. 18-23.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Effect of human papillomavirus and Chlamydia trachomatis co-infection on sperm quality in young heterosexual men with chronic prostatitis-related symptoms / Т. Cai [et al.] // BJU Int. - 2014 Feb. - Vol. 113 (2). - Р. 281-7.</mixed-citation><mixed-citation xml:lang="en">Effect of human papillomavirus and Chlamydia trachomatis co-infection on sperm quality in young heterosexual men with chronic prostatitis-related symptoms / Т. Cai [et al.] // BJU Int. - 2014 Feb. - Vol. 113 (2). - Р. 281-7.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ivanov I. B. Phenotypic differences between coagulase-negative staphylococci isolated from seminal fluid of healthy men and men suffering from chronic prostatitis syndrome / I. B. Ivanov, V. A. Gritsenko, M. D. Kuzmin // Int. J. Androl. - 2010 Jun. - Vol. 1, N 33 (3). - Р. 563-7.</mixed-citation><mixed-citation xml:lang="en">Ivanov I. B. Phenotypic differences between coagulase-negative staphylococci isolated from seminal fluid of healthy men and men suffering from chronic prostatitis syndrome / I. B. Ivanov, V. A. Gritsenko, M. D. Kuzmin // Int. J. Androl. - 2010 Jun. - Vol. 1, N 33 (3). - Р. 563-7.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dohle G. R. Inflammatory-associated obstructions of the male reproductive tract / G. R. Dohle // Andrologia. - 2003 Oct. - Vol. 35 (5). - Р. 321-4.</mixed-citation><mixed-citation xml:lang="en">Dohle G. R. Inflammatory-associated obstructions of the male reproductive tract / G. R. Dohle // Andrologia. - 2003 Oct. - Vol. 35 (5). - Р. 321-4.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Changes of seminal parameters, zinc concentration and antibacterial activity in patients with non-inflammatory chronic prostatitis/chronic pelvic pain syndrome / Н. Zhao [et al.] // Zhonghua Nan Ke Xue. - 2008 Jun. - Vol. 14 (6). - Р. 530-2.</mixed-citation><mixed-citation xml:lang="en">Changes of seminal parameters, zinc concentration and antibacterial activity in patients with non-inflammatory chronic prostatitis/chronic pelvic pain syndrome / Н. Zhao [et al.] // Zhonghua Nan Ke Xue. - 2008 Jun. - Vol. 14 (6). - Р. 530-2.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Infertility, in vitro fertilization and congenital tuberculosis / J. J. Flibotte [et al.] // J. Perinatol. - 2013 Jul. - Vol. 33 (7). - Р. 565-8.</mixed-citation><mixed-citation xml:lang="en">Infertility, in vitro fertilization and congenital tuberculosis / J. J. Flibotte [et al.] // J. Perinatol. - 2013 Jul. - Vol. 33 (7). - Р. 565-8.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Antimicrobial therapy for chronic bacterial prostatitis / G. Perletti [et al.] // Cochrane Database Syst. Rev. - 2013 Aug 12. - Vol. 8.</mixed-citation><mixed-citation xml:lang="en">Antimicrobial therapy for chronic bacterial prostatitis / G. Perletti [et al.] // Cochrane Database Syst. Rev. - 2013 Aug 12. - Vol. 8.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Is leukocytospermia clinically relevant? / Е. Н. Yanushpolsky [et al.] // Fertil Steril. - 1996 Nov. - Vol. 66 (5). - Р. 822-5.</mixed-citation><mixed-citation xml:lang="en">Is leukocytospermia clinically relevant? / Е. Н. Yanushpolsky [et al.] // Fertil Steril. - 1996 Nov. - Vol. 66 (5). - Р. 822-5.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters / Т. Domes [et al.] // Fertil Steril. - 2012 May. - Vol. 97 (5). - Р. 1050-5.</mixed-citation><mixed-citation xml:lang="en">The incidence and effect of bacteriospermia and elevated seminal leukocytes on semen parameters / Т. Domes [et al.] // Fertil Steril. - 2012 May. - Vol. 97 (5). - Р. 1050-5.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Кульчавеня Е. В. Избранные вопросы фтизиоурологии / Е. В. Кульчавеня, В. А. Краснов. - Новосибирск : Наука, 2010. - 142 с.</mixed-citation><mixed-citation xml:lang="en">Кульчавеня Е. В. Избранные вопросы фтизиоурологии / Е. В. Кульчавеня, В. А. Краснов. - Новосибирск : Наука, 2010. - 142 с.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kulchavenya E. Diagnosis and therapy for prostate tuberculosis / E. Kulchavenya, E. Brizhatyuk, V. Khomyakov // Therapeutic Advances in Urology. - 2014. - Vol. 6 (4). - Р. 129-134.</mixed-citation><mixed-citation xml:lang="en">Kulchavenya E. Diagnosis and therapy for prostate tuberculosis / E. Kulchavenya, E. Brizhatyuk, V. Khomyakov // Therapeutic Advances in Urology. - 2014. - Vol. 6 (4). - Р. 129-134.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mirone M. Selenium and reproductive function. A systematic review / М. Mirone, E. Giannetta, A. M. Isidori // J. Endocrinol. Invest. - 2013 Nov. - Vol. 36 (10 Suppl). - Р. 28-36.</mixed-citation><mixed-citation xml:lang="en">Mirone M. Selenium and reproductive function. A systematic review / М. Mirone, E. Giannetta, A. M. Isidori // J. Endocrinol. Invest. - 2013 Nov. - Vol. 36 (10 Suppl). - Р. 28-36.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Walczak-Jedrzejowska R. The role of oxidative stress and antioxidants in male fertility / R. Walczak-Jedrzejowska, J. K. Wolski, J. Slowikowska-Hilczer // Cent. European J. Urol. - 2013. - Vol. 66 (1). - Р. 60-7.</mixed-citation><mixed-citation xml:lang="en">Walczak-Jedrzejowska R. The role of oxidative stress and antioxidants in male fertility / R. Walczak-Jedrzejowska, J. K. Wolski, J. Slowikowska-Hilczer // Cent. European J. Urol. - 2013. - Vol. 66 (1). - Р. 60-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Мохирева Л. В. Биологическая роль цинка в организме человека / Л. В. Мохирева, И. В. Богадельникова // Туберкулез и болезни легких. - 2011. - № 7. - С. 3-10.</mixed-citation><mixed-citation xml:lang="en">Мохирева Л. В. Биологическая роль цинка в организме человека / Л. В. Мохирева, И. В. Богадельникова // Туберкулез и болезни легких. - 2011. - № 7. - С. 3-10.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Effects of a dietary supplement on chronic pelvic pain syndrome (Category IIIA), leucocytospermia and semen parameters / F. Lombardo [et al.] // Andrologia. - 2012 May. - Vol. 44, Suppl 1. - Р. 672-8.</mixed-citation><mixed-citation xml:lang="en">Effects of a dietary supplement on chronic pelvic pain syndrome (Category IIIA), leucocytospermia and semen parameters / F. Lombardo [et al.] // Andrologia. - 2012 May. - Vol. 44, Suppl 1. - Р. 672-8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Verification of the effectiveness of the dietary supplementation in infertility treatment / М. Witkowska-Zimny [et al.] // Pol. Merkur. Lekarski. - 2013 Dec. - Vol. 35 (210). - Р. 347-51.</mixed-citation><mixed-citation xml:lang="en">Verification of the effectiveness of the dietary supplementation in infertility treatment / М. Witkowska-Zimny [et al.] // Pol. Merkur. Lekarski. - 2013 Dec. - Vol. 35 (210). - Р. 347-51.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Применение препарата Селцинк Плюс у больных хроническим неинфекционным простатитом и нарушениями фертильности. / А. В. Сивков [и др.] // Урология. - 2011. - № 5. - С. 27-33.</mixed-citation><mixed-citation xml:lang="en">Применение препарата Селцинк Плюс у больных хроническим неинфекционным простатитом и нарушениями фертильности. / А. В. Сивков [и др.] // Урология. - 2011. - № 5. - С. 27-33.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
