jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-450Research ArticleСтатьиEndothelial hemostatic predictors of cardiovascular risk in patients with vibration disease in combination with the arterial hypertensionShpaginaL. A.noemail@neicon.ruGerasimenkoO. N.noemail@neicon.ruDrobyshevV. A.doctorvik@yandex.ruKuznetsovaG. V.noemail@neicon.ruNovosibirsk State Medical University; City Clinical Hospital No. 2, NovosibirskRussian FederationNovosibirsk State Medical UniversityRussian Federation2017040620180136Copyright © Shpagina L.A., Gerasimenko O.N., Drobyshev V.A., Kuznetsova G.V., 20182018Shpagina L.A., Gerasimenko O.N., Drobyshev V.A., Kuznetsova G.V.Shpagina L.A., Gerasimenko O.N., Drobyshev V.A., Kuznetsova G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/450

We have investigated levels of vascular endothelial growth factor, thrombomodulin, plateletderived growth factor BB, transforming growth factor β1, fibronectin, thrombospondin, alpha2macroglobulin, fibrinopeptide A, and adhesion molecules in patients with vibration disease (VD), hypertension, and with combination of both diseases. It has been revealed that the blood serum of VD patients with hypertension has the high content of endothelial cell indicators (vascular endothelial growth factor BB, transforming growth factor β1, plateletderived growth factor BB, fibronectin, thrombomodulin, thrombospondin, alfa2macroglobulin, fibrinopeptide A, and adhesion molecules), which are responsible for the membrane platelet activation, and intracellular synthesis of endogenous proaggregants and thrombogenesis, and that allows us to consider them as early markers of increased cardiovascular risk.

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The authors declare that there are no conflicts of interest present.