jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-455Research ArticleСтатьиGenetic markers of cardiovascular risk in patients with hand­arm vibration syndrome combined with arterial hypertensionShpaginaL. A.noemail@neicon.ruGerasimenkoO. N.noemail@neicon.ruChachibayaZ. K.noemail@neicon.ruDrobyshevV. A.doctorvik@yandex.ruKuznetsovaG. V.noemail@neicon.ruNovosibirsk State Medical University; City Clinical Hospital No. 2, NovosibirskRussian FederationCity Clinical Hospital No. 2, NovosibirskRussian Federation201704062018012931Copyright © Shpagina L.A., Gerasimenko O.N., Chachibaya Z.K., Drobyshev V.A., Kuznetsova G.V., 20182018Shpagina L.A., Gerasimenko O.N., Chachibaya Z.K., Drobyshev V.A., Kuznetsova G.V.Shpagina L.A., Gerasimenko O.N., Chachibaya Z.K., Drobyshev V.A., Kuznetsova G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/455

We investigated polymorphism of genes of endothelin I (EDN1), endothelial NOsynthase (NOS3(e)), plasminogen activator type 1 (PAI1) in patients suffered from handarm vibration syndrome (HAVS), arterial hypertension (АH), and combined course of HAVS and AH. In most cases we revealed pathological variants of genes of endothelin I, endothelial NOsynthase, and plasminogen activator type 1 taking part in regulation of endothelium and systemic hemostasis function. This fact allows to consider such gene pathology as early markers of higher risk of thrombogenic and thrombophilic disorders.

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The authors declare that there are no conflicts of interest present.