jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-456Research ArticleСтатьиPathogenetic mechanisms of perinatal damage of the central nervous system in case of prenatal encephalitis at the fetusesPerovaO. V.noemail@neicon.ruNadeevA. P.nadeevngma@mail.ruTravinM. A.noemail@neicon.ruNovosibirsk State Medical UniversityRussian Federation201704062018013236Copyright © Perova O.V., Nadeev A.P., Travin M.A., 20182018Perova O.V., Nadeev A.P., Travin M.A.Perova O.V., Nadeev A.P., Travin M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/456

We studied the paraventricular zone of thalamic area of a brain of 47 fetuses with signs of prenatal encephalitis in case of the term of a gestation of 26-27 weeks in comparison with 10 healthy fetuses in case of the same term. We showed that pathomorphologic changes in brain of human fetuses in case cellularity of prenatal encephalitis are characterized by a productive and necrotic inflammation. Reduction of cellularity of paraventricular zone, increase in amount of neurons and glial cells in thalamic area, and also the cells he expressing glial fibrous protein, the increased proliferative activity of cells of paraventricular zone indicated the accelerated maturation of its cells in case of prenatal encephalitis. Reduction of number of vessels in paraventricular zone was caused by decrease in expression of vascular endothelial factor of growth and transforming growth factor in cells.

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The authors declare that there are no conflicts of interest present.