jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-460Research ArticleСтатьиMarkers of thrombophilia and endothelial dysfunction under the technogenic influence of the dust factorCikalenkoE. A.noemail@neicon.ruDornO. Ju.olga_dorn@ngs.ruPeskovS. A.noemail@neicon.ruStepanovaE. G.noemail@neicon.ruPalamarchukM. V.noemail@neicon.ruVohmincevaL. V.noemail@neicon.ruNovosibirsk State Medical University; City Clinical Hospital No. 1Russian FederationNovosibirsk State Medical UniversityRussian Federation2017040620180235Copyright © Cikalenko E.A., Dorn O.J., Peskov S.A., Stepanova E.G., Palamarchuk M.V., Vohminceva L.V., 20182018Cikalenko E.A., Dorn O.J., Peskov S.A., Stepanova E.G., Palamarchuk M.V., Vohminceva L.V.Cikalenko E.A., Dorn O.J., Peskov S.A., Stepanova E.G., Palamarchuk M.V., Vohminceva L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/460

Thrombophilia markers (rising of activity of the VIII coagulation factor, decrease of the activity of protein C) and endothelial dysfunction (rising of activity of von Willebrand factor, contents of glycosaminoglycans in blood, and microalbuminuria) are revealed at the prolonged technogenic impact of the dust factor in workers of the dust hazardous jobs. The revealed markers of thrombophilia and endothelial dysfunction correlate with degree of fibrogenity of dust aerosols in the workers contacting with highly fibrogenic and mild fibrogenic dust aerosols.

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The authors declare that there are no conflicts of interest present.