We have examined 45 men and women at the age of 45 to 59 with osteoarthritis of the knee joints complained of a pain syndrome and limitation of motion in the lower extremities. All patients were divided into 3 groups: in the first group the basic medical treatment was supplemented with ultraphonophoresis of chitosan gel Viprazan with adder venom on the affected joints; in the second group it was carried out placebo procedure of ultraphonophoresis; in the third group the basic treatment was supplemented with application of Viprazan gel on painful zones during three weeks. Based on the research findings we have established that introduction by ultrasound of the gel Viprazan in circumarticular tissues promotes the decrease of indicators of the pain, constraint and functional insufficiency. According to WOMAC questionnaire the indicators of the pain, constraint and functional insufficiency were decreased 1.3 times, and total index - 1.2 times. Upon completion of a therapeutic course in patients of the first group it was noted the increase of degree of restoration of function of a joint up to 84.2% and an index of efficiency of microcirculation 2.1 times that was not observed in the placebo and comparison groups.