jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-466Research ArticleСтатьиResearch of the genetic polymorphism of Tolllike receptors in the patients suffering from tuberculosis of respiratory organsBogodukhovaE. S.bogoduxowa@yandex.ruBaykeE. E.noemail@neicon.ruChita State Medical AcademyRussian Federation201704062018022732Copyright © Bogodukhova E.S., Bayke E.E., 20182018Bogodukhova E.S., Bayke E.E.Bogodukhova E.S., Bayke E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/466

Development of tuberculosis is caused by many reasons, but the main is depression of efficiency of functioning of the immune system. The purpose of the work was to identify the frequency of occurrence of alleles and genotypes of TLR2 (Arg753Gln), TLR3 (Phe412Leu), TLR4 (Asp299Gly), TLR6 (Ser249Pro) genes in patients suffering from tuberculosis. The research is performed on the basis of the analysis of clinical findings of 120 patients suffering from tuberculosis and 30 healthy peoples. For studying of a polymorphism of genes of Tolllike receptors (TLRs) we used the method of specific allele polymerase chain reaction with electrophoretic detection. Crucial importance for development of small forms and infiltrative tuberculosis has genetic predisposition in the form of a carriage of mutant genotypes of TLR3 (Phe412Leu) and TLR6 (Ser249Pro) genes. At the same time in pathogenesis of disseminated tuberculosis an important role is played by such factors as an alcoholism, an abuse of narcotics, contact to extractors, etc. The influence of external environment and genetic predisposition in the form of mutant variant of a polymorphism of a gene of TLR6 (Ser249Pro) are characterized by the fibrous and cavernous tuberculosis. The risk ratio of development of tuberculosis in carriers of mutant variants of polymorphism of TLR3 (Phe412Leu) and TLR6 (Ser249Pro) genes is higher in comparison with other variants of polymorphism of the same and other genes.

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The authors declare that there are no conflicts of interest present.