jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)jsms-468Research ArticleСтатьиChoice and justification of the method of bacterial purification of hormonal substances at production of medicinal preparations in suspension form for injections in rheumatologyKachaputA. I.o.kachaput@farmak.uaCentral Laboratory of Pharmaceutical Development Farmak JointStock Company, Kiev, UkraineRussian Federation201704062018023641Copyright © Kachaput A.I., 20182018Kachaput A.I.Kachaput A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/468

The aim of our research is to choose and justify the method of bacterial purification of hormonal substances of active ingredients of betamethasone dipropionate and hydrocortisoni acetas at developing of the most acceptable ways of receiving sterile prepared parenteral suspensions of «Hydrocortisoni Acetas + Lidocaine Hydrochloride» and «Betamethasone» is conducted. We developed two technological methods for obtaining these medicinal preparations which are characterized by identical final quality. They correspond the requirements of the State pharmacopoeia of Ukraine and the European regulatory requirements concerning the choice of a method of bacterial purification of the readymade dosage forms.

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The authors declare that there are no conflicts of interest present.