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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-493</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Экспертная оценка морфологических изменений при ожоговом шоке</article-title><trans-title-group xml:lang="en"><trans-title>Expert assessment of morphological changes under burn shock</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савченко</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Savchenko</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">dr.serg62@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ощепкова</surname><given-names>Н. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Oshchepkova</surname><given-names>N. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новоселов</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Novoselov</surname><given-names>V. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицингер</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritsinger</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тихонов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tikhonov</surname><given-names>V. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецов</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsov</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>04</day><month>12</month><year>2018</year></pub-date><volume>0</volume><issue>2</issue><fpage>10</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Савченко С.В., Ощепкова Н.Г., Новоселов В.П., Грицингер В.А., Тихонов В.В., Кузнецов Е.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Савченко С.В., Ощепкова Н.Г., Новоселов В.П., Грицингер В.А., Тихонов В.В., Кузнецов Е.В.</copyright-holder><copyright-holder xml:lang="en">Savchenko S.V., Oshchepkova N.G., Novoselov V.P., Gritsinger V.A., Tikhonov V.V., Kuznetsov E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/493">https://jsms.elpub.ru/jour/article/view/493</self-uri><abstract><p>С целью оценки морфологии ожогового шока был проведен анализ данных 153 «Актов судебно-медицинского исследования трупов» и «Заключений эксперта» за период с 2012 по 2017 год, среди которых 93.2 % экспертных наблюдений составили умершие в комбустиологическом центре, в 6.8 % случаев погибшие были доставлены с места происшествия. Патоморфологические изменения при ожоговом шоке характеризуются развитием острых дистрофических изменений клеток и отеком стромы внутренних органов на фоне выраженных микроциркуля-торных расстройств. Информативной при ожоговом шоке является оценка морфодинамики дистрофических и некробиотических изменений кардиомиоцитов и острых расстройств кровообращения миокарда. Неравномерность описанных проявлений в различных случаях развития ожогового шока обусловлена, прежде всего, тяжестью развившегося шока и сроками оказания медицинской помощи в условиях комбустиологического центра.</p></abstract><trans-abstract xml:lang="en"><p>To assess burn shock morphology, the data of 153 forensic autopsy reports and expert medical reports for the period from 2012 to 2017 were analyzed, among which 93.2 % of expert observations were deaths certified at burn centers and 6.8 % cases were deaths certified by first responders. Pathomorphological changes under burn shock are characterized by development of acute dystrophic changes in cells and stromal edemas of internal organs in context of pronounced microcirculatory impairments. Assessment of morphodynamics of dystrophic and necrobiotic changes in cardiomyocytes and acute myocardial blood circulation impairments is of information value under burn shock. Nonuniformity of the manifestations described in various cases of burn shock is primarily caused by the severity of shock and emergency of medical treatment at a burn center.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожоговый шок</kwd><kwd>морфологические изменения</kwd><kwd>оценка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>burn shock</kwd><kwd>morphological changes</kwd><kwd>assessment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аминов У.Х., Хакимов Э.А., Карабаев Ж.Ш., Некбаев Х.С., Шаханов Ш.С. Летальность при ожоговой болезни //4 съезд комбустиологов России. М., 2013. С. 12-14.</mixed-citation><mixed-citation xml:lang="en">Аминов У.Х., Хакимов Э.А., Карабаев Ж.Ш., Некбаев Х.С., Шаханов Ш.С. Летальность при ожоговой болезни //4 съезд комбустиологов России. М., 2013. С. 12-14.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Матвеев С.Б., Смирнов С.В., Тазина Е.В. и др. Динамика эндогенной интоксикации у пациентов с обширными ожогами // Клиническая лабораторная диагностика. 2013. № 2. С. 10-12.</mixed-citation><mixed-citation xml:lang="en">Матвеев С.Б., Смирнов С.В., Тазина Е.В. и др. Динамика эндогенной интоксикации у пациентов с обширными ожогами // Клиническая лабораторная диагностика. 2013. № 2. С. 10-12.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Исхизова Л.Н., Туманов В.П. Динамика морфологических изменений в центральной нервной системе как критерий прижизненности термической травмы // Суд.-мед. экспертиза. 2003. № 1. С. 7.</mixed-citation><mixed-citation xml:lang="en">Исхизова Л.Н., Туманов В.П. Динамика морфологических изменений в центральной нервной системе как критерий прижизненности термической травмы // Суд.-мед. экспертиза. 2003. № 1. С. 7.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Лекманов А.У., Азовский Д.А., Пилютик С.Ф. Пути снижения инфузионной нагрузки у детей с обширными ожогами в первые 24 часа после повреждения // Вестн. анестезиологии и реаниматологии. 2016. Т. 13, № 4. С. 30-36.</mixed-citation><mixed-citation xml:lang="en">Лекманов А.У., Азовский Д.А., Пилютик С.Ф. Пути снижения инфузионной нагрузки у детей с обширными ожогами в первые 24 часа после повреждения // Вестн. анестезиологии и реаниматологии. 2016. Т. 13, № 4. С. 30-36.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Belba M., Belba G. Acute renal failure in severe burns. Conclusions after analyses of deaths during 1998 // Ann. of Burns and Fire Disasters. 2000. Vol. 13. No. 2.</mixed-citation><mixed-citation xml:lang="en">Belba M., Belba G. Acute renal failure in severe burns. Conclusions after analyses of deaths during 1998 // Ann. of Burns and Fire Disasters. 2000. Vol. 13. No. 2.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Haik J., Liran A., Tessone A. et al. Burns in Israel: demographic, etiologic and clinical trends during 1997-2003 // IMAJ. 2007. No. 9. Р. 659-662.</mixed-citation><mixed-citation xml:lang="en">Haik J., Liran A., Tessone A. et al. Burns in Israel: demographic, etiologic and clinical trends during 1997-2003 // IMAJ. 2007. No. 9. Р. 659-662.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chaudhary I. Burns: frequency and mortality related to various age groups // J. Surg. Pakistan (International). 2009. Vol. 14, No. 2, Р. 67-71, 194.</mixed-citation><mixed-citation xml:lang="en">Chaudhary I. Burns: frequency and mortality related to various age groups // J. Surg. Pakistan (International). 2009. Vol. 14, No. 2, Р. 67-71, 194.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Pham T.N., Cancio L.C., Gibran N.S. American Burn Association practice guidelines burn shock resuscitation // J. Burn. Care Res. 2008. Vol. 29, No. 1. P. 257-266.</mixed-citation><mixed-citation xml:lang="en">Pham T.N., Cancio L.C., Gibran N.S. American Burn Association practice guidelines burn shock resuscitation // J. Burn. Care Res. 2008. Vol. 29, No. 1. P. 257-266.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Новоселов В.П., Савченко С.В., Саковчук О.А., Грицингер В.А., Надеев А.П. Оценка морфологии реактивных изменений при повреждении мягких тканей и почек в условиях кровопотери // Вестн. судебной медицины. 2013. Т. 2, № 4. С. 24-27.</mixed-citation><mixed-citation xml:lang="en">Новоселов В.П., Савченко С.В., Саковчук О.А., Грицингер В.А., Надеев А.П. Оценка морфологии реактивных изменений при повреждении мягких тканей и почек в условиях кровопотери // Вестн. судебной медицины. 2013. Т. 2, № 4. С. 24-27.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Новоселов В.П., Савченко С.В., Воронковская М.В. Патоморфологические изменения селезенки при определении давности ее двухмоментного разрыва// Вестн. судебной медицины. 2013. Т. 2. № 3. С. 54-58.</mixed-citation><mixed-citation xml:lang="en">Новоселов В.П., Савченко С.В., Воронковская М.В. Патоморфологические изменения селезенки при определении давности ее двухмоментного разрыва// Вестн. судебной медицины. 2013. Т. 2. № 3. С. 54-58.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Реаниматология / под. ред. Г.Н. Цибуляка. Л.: Медицина, 1982. 378 с.</mixed-citation><mixed-citation xml:lang="en">Реаниматология / под. ред. Г.Н. Цибуляка. Л.: Медицина, 1982. 378 с.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Савченко С.В. Патоморфологические исследования в судебно-медицинской практике на современном этапе // Вестн. судебной медицины. 2015. Т. 4, № 2. С. 21-24.</mixed-citation><mixed-citation xml:lang="en">Савченко С.В. Патоморфологические исследования в судебно-медицинской практике на современном этапе // Вестн. судебной медицины. 2015. Т. 4, № 2. С. 21-24.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Адкин В.И., Кинле А.Ф. Судебно-медицинская диагностика и оценка травматической жировой эмболии: Метод. письмо. М., 1989. 27 с.</mixed-citation><mixed-citation xml:lang="en">Адкин В.И., Кинле А.Ф. Судебно-медицинская диагностика и оценка травматической жировой эмболии: Метод. письмо. М., 1989. 27 с.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Aminov U.Kh., Khakimov E.A., Karabaev Zh.Sh, Nekbaev Kh.S., Shakhanov Sh.S. (2013). Mortality rate under burn disease. 4 Conference of Russian Combustiologists. Moscow, 12-14. In Russ.</mixed-citation><mixed-citation xml:lang="en">Aminov U.Kh., Khakimov E.A., Karabaev Zh.Sh, Nekbaev Kh.S., Shakhanov Sh.S. (2013). Mortality rate under burn disease. 4 Conference of Russian Combustiologists. Moscow, 12-14. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Matveyev S.B., Smirnov S.V., Tazina E.V. et al. (2013). The dynamics of endogenic intoxication in patients with extensive burns. Russian Clinical Laboratory Diagnostics, 2, 10-12.</mixed-citation><mixed-citation xml:lang="en">Matveyev S.B., Smirnov S.V., Tazina E.V. et al. (2013). The dynamics of endogenic intoxication in patients with extensive burns. Russian Clinical Laboratory Diagnostics, 2, 10-12.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Iskhizova L.N., Tumanov V.P. (2003). Dynamics of morphological changes in central nervous system as an intravitality criterion of thermal trauma. Forensic Medical Expertise, 1, 7. In Russ.</mixed-citation><mixed-citation xml:lang="en">Iskhizova L.N., Tumanov V.P. (2003). Dynamics of morphological changes in central nervous system as an intravitality criterion of thermal trauma. Forensic Medical Expertise, 1, 7. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Lekmanov A.U., Azovskiy D.A., Pilyutik S.F. (2016). Infusion load reduction in children with extensive burns in the first 24 hours after trauma. Messenger of Anesthesiology and Resuscitation, 13, 4, 30-36. In Russ.</mixed-citation><mixed-citation xml:lang="en">Lekmanov A.U., Azovskiy D.A., Pilyutik S.F. (2016). Infusion load reduction in children with extensive burns in the first 24 hours after trauma. Messenger of Anesthesiology and Resuscitation, 13, 4, 30-36. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Belba M., Belba G. (2000). Acute renal failure in severe burns. Conclusions after analyses of deaths during 1998. Ann. of Burns and Fire Disasters, 13, 2.</mixed-citation><mixed-citation xml:lang="en">Belba M., Belba G. (2000). Acute renal failure in severe burns. Conclusions after analyses of deaths during 1998. Ann. of Burns and Fire Disasters, 13, 2.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Haik J., Liran A., Tessone A. et al. (2007). Burns in Israel: demographic, etiologic and clinical trends during 1997-2003. IMAJ, 9, 659-662.</mixed-citation><mixed-citation xml:lang="en">Haik J., Liran A., Tessone A. et al. (2007). Burns in Israel: demographic, etiologic and clinical trends during 1997-2003. IMAJ, 9, 659-662.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Chaudhary I. (2009). Burns: frequency and mortality related to various age groups. J. Surg. Pakistan (International), 14, 2, 67-71, 194.</mixed-citation><mixed-citation xml:lang="en">Chaudhary I. (2009). Burns: frequency and mortality related to various age groups. J. Surg. Pakistan (International), 14, 2, 67-71, 194.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pham T.N., Cancio L.C., Gibran N.S. (2008). American Burn Association practice guidelines burn shock resuscitation. J. Burn. Care Res., 29, 1, 257-266.</mixed-citation><mixed-citation xml:lang="en">Pham T.N., Cancio L.C., Gibran N.S. (2008). American Burn Association practice guidelines burn shock resuscitation. J. Burn. Care Res., 29, 1, 257-266.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Novoselov V.P., Savchenko S.V., Sakovchuk O.A., Gritsinger V.A., Nadeev A.P. (2013). Morphological assessment of reactive changes under soft tissue and renal lesions with blood loss. Bulletin of Forensic Medicine, 2, 4, 24-27. In Russ.</mixed-citation><mixed-citation xml:lang="en">Novoselov V.P., Savchenko S.V., Sakovchuk O.A., Gritsinger V.A., Nadeev A.P. (2013). Morphological assessment of reactive changes under soft tissue and renal lesions with blood loss. Bulletin of Forensic Medicine, 2, 4, 24-27. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Novoselov V.P., Savchenko S.V., Voronkovskaya M.V. (2013). Splenic patomorphological changes in determination of two-stage rupture time. Bulletin of Forensic Medicine, 2, 3, 54-58. In Russ.</mixed-citation><mixed-citation xml:lang="en">Novoselov V.P., Savchenko S.V., Voronkovskaya M.V. (2013). Splenic patomorphological changes in determination of two-stage rupture time. Bulletin of Forensic Medicine, 2, 3, 54-58. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tsibulyak G.N. (Ed.) (1982). Resuscitation science. Leningrad: Medicine, 378 p. In Russ.</mixed-citation><mixed-citation xml:lang="en">Tsibulyak G.N. (Ed.) (1982). Resuscitation science. Leningrad: Medicine, 378 p. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Savchenko S.V. (2015). Patho-morphologic research in medico-legal practice at the present stage. Bulletin of Forensic Medicine, 4, 2, 21-24.</mixed-citation><mixed-citation xml:lang="en">Savchenko S.V. (2015). Patho-morphologic research in medico-legal practice at the present stage. Bulletin of Forensic Medicine, 4, 2, 21-24.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Adkin V.I., Kinle A.F. (1989). Forensic diagnostics and assessment of traumatic fat embolism. Methodological Letter. Moscow, 27 p. In Russ.</mixed-citation><mixed-citation xml:lang="en">Adkin V.I., Kinle A.F. (1989). Forensic diagnostics and assessment of traumatic fat embolism. Methodological Letter. Moscow, 27 p. In Russ.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
