<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2019-4-20-29</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-589</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Внебольничная пневмония: эпидемиология, этиология и клинико-морфологические параллели</article-title><trans-title-group xml:lang="en"><trans-title>Community-acquired pneumonia: epidemiology, etiology and clinical-morphological parallels</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Надеев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nadeev</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Надеев Александр Петрович — д-р мед. наук, профессор, заведующий кафедрой патологической анатомии</p><p>врач-патологоанатом</p><p>630091, г. Новосибирск, Красный просп., 52</p></bio><bio xml:lang="en"><p>Nadeev Aleksandr Petrovich — Dr. Sci. (Med.), Professor, Head of the Pathological Anatomy Department</p><p>Pathologist</p></bio><email xlink:type="simple">nadeevngma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козяев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozyaev</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козяев Михаил Александрович — канд. мед. наук, доцент кафедры патологической анатомии</p><p>заведующий патолого-анатомическим отделением</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Kozyaev Mikhail Aleksandrovich — Cand. Sci. (Med.), Assistant Professor of the Pathological Anatomy Department</p><p>Head of the Pathology Department,</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абышев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abyshev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абышев Александр Андреевич — аспирант кафедры патологической анатомии</p></bio><bio xml:lang="en"><p>Abyshev Aleksandr Andreyevich — Post-graduate Student of the Pathological Anatomy Department</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чеканов</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chekanov</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чеканов Михаил Николаевич — д-р мед. наук, профессор кафедры общей хирургии</p></bio><bio xml:lang="en"><p>Chekanov Mikhail Nikolayevich — Dr. Sci. (Med.), Professor of the General Surgery Department</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благитко</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Blagitko</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Благитко Евгений Михайлович — д-р мед. наук, профессор кафедры госпитальной и детской хирургии</p></bio><bio xml:lang="en"><p>Blagitko Evgeny Mikhaylovich — Dr. Sci. (Med.), Professor of the Hospital and Pediatric Surgery Department</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пешкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Peshkova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пешкова Инесса Викторовна — д-р мед. наук, доцент кафедры анестезиологии и реаниматологии им. проф. И.П. Верещагина</p></bio><bio xml:lang="en"><p>Peshkova Inessa Viktorovna — Dr. Sci. (Med.), Assistant Professor of the Anesthesiology and Critical Care Medicine n.a. Professor I.P. Vereshchagin Department</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овсянко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovsyanko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овсянко Елена Владимировна — д-р мед. наук, профессор кафедры анатомии человека</p></bio><bio xml:lang="en"><p>Ovsyanko Elena Vladimirovna — Dr. Sci. (Med.), Professor of the Human Anatomy Department</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; &#13;
ГБУЗ НСО «Городская клиническая больница № 1»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University; &#13;
Novosibirsk City Clinical Hospital No. 2</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>4</issue><fpage>20</fpage><lpage>29</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Надеев А.П., Козяев М.А., Абышев А.А., Чеканов М.Н., Благитко Е.М., Пешкова И.В., Овсянко Е.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Надеев А.П., Козяев М.А., Абышев А.А., Чеканов М.Н., Благитко Е.М., Пешкова И.В., Овсянко Е.В.</copyright-holder><copyright-holder xml:lang="en">Nadeev A.P., Kozyaev M.A., Abyshev A.A., Chekanov M.N., Blagitko E.M., Peshkova I.V., Ovsyanko E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/589">https://jsms.elpub.ru/jour/article/view/589</self-uri><abstract><p>С целью изучения гендерных, возрастных особенностей, этиологии, клинико-морфологических форм внебольничных пневмоний, приведших к летальному исходу, проведена ретроспективная оценка результатов патолого-анатомических исследований умерших больных с внебольничными пневмониями, находившихся на лечении в ГБУЗ НСО «Городская клиническая больница № 1» г. Новосибирска в 2016–2018 гг. Проводились морфологическое и бактериологическое исследования образцов легких умерших пациентов с диагнозом пневмонии.</p><p>Выявлено, что летальные исходы вследствие внебольничной пневмонии чаще наблюдались у мужчин, чем у женщин, в пожилом и старческом возрасте (56–67 %). Доля летальных исходов вследствие внебольничной пневмонии от всего количества патолого-анатомических вскрытий составила 2.6–3.8 %. Досуточная летальность отмечалась в 15–32 % случаев. Расхождение клинического и патолого-анатомического диагнозов достигало 17.6 %. Наиболее распространенными верифицированными возбудителями внебольничной пневмонии оказались Klebsiella pneumoniaе, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, а также микст-инфекция. Основной клинико-морфологической формой внебольничной пневмонии являлась распространенная бронхопневмония (гнойная, с абсцедированием) (до 87.8 %), не имеющая специфической, зависящей от вида возбудителя, морфологической картины.</p><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.</p></abstract><trans-abstract xml:lang="en"><p>Retrospective assessment of results of pathoanatomical researches on the deceased patients with community-acquired pneumonia treated in City Clinical Hospital No. 1 (Novosibirsk) in 2016–2018 is carried out for the purpose of studying gender, age features, etiology, clinical-morphological forms of the community-acquired pneumonia which resulted in lethal outcome. Morphological and bacteriological researches of lung samples in deceased patients with the diagnosis of pneumonia were conducted.</p><p>It is revealed that lethal outcomes owing to community-acquired pneumonia were more often observed in men, than in women, at advanced and senile age (56–67%). The rate of lethal outcomes owing to community-acquired pneumonia among all number of pathoanatomical thanatopsy made 2.6–3.8%. Lethality within the period of 24 hours of hospitalization was registered in 15–32% of cases. The divergence of clinical and pathoanatomical diagnoses reached 17.6%. Klebsiella pneumoniaе, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and also mixed-strain infection were the most widespread verifi ed causative agents of community-acquired pneumonia. The main clinical-morphological form of community-acquired pneumonia was the widespread bronchial pneumonia (purulent, with abscessing) (up to 87.8%) which did not present specifi c morphological picture depending on a type of the causative agent.</p><p>Conflict of interest. The authors declare no conflict of interest.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внебольничные пневмонии</kwd><kwd>этиология</kwd><kwd>эпидемиология</kwd><kwd>летальность</kwd><kwd>морфологические проявления</kwd></kwd-group><kwd-group xml:lang="en"><kwd>community-acquired pneumonia</kwd><kwd>etiology</kwd><kwd>epidemiology</kwd><kwd>lethality</kwd><kwd>morphological manifestations</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Круглякова Л.В., Нарышкина С.В. Тяжелая внебольничная пневмония: диагностика и лечение (обзор литературы) // Бюл. физиологии и патологии дыхания. 2016. № 59. С. 98–108.</mixed-citation><mixed-citation xml:lang="en">Kruglyakova L.V., Naryshkina S.V. (2016). Severe community-acquired pneumonia: diagnostics and treatment (review). Bulletin Physiology and Pathology of Respiration, 59, 98–108.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ewig S., Birkner N., Strauss R. et al. New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality // Thorax. 2009. Vol. 64 (12). P. 1062–1069.</mixed-citation><mixed-citation xml:lang="en">Ewig S., Birkner N., Strauss R. et al. (2009). New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax, 64 (12), 1062–1069.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Благонравова А.С., Чубукова О.А., Широкова И.Ю., Коротаева С.В. Внебольничная пневмония у госпитализированных пациентов // Эпидемиология и вакцинопрофилактика. 2011. № 6 (61). С. 71–78.</mixed-citation><mixed-citation xml:lang="en">Blagonravova A.S., Chubukova O.A., Shirokova I.Yu., Korotaeva S.V. (2011). Community-acquired pneumonia in hospitalized patients. Epidemiology and Vaccinal Prevention, 6 (61), 71–78.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Вёрткин А.Л., Зайратьянц О.В., Вовк Е.И. Окончательный диагноз. М.: ГЭОТАР-Медиа, 2009. 576 с.</mixed-citation><mixed-citation xml:lang="en">Vyortkin A.L., Zayratyants O.V., Vovk E.I. (2009). Final Diagnosis. Moscow: GEOTAR-Media, 576 p. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lin C.J., Chang Y.C., Tsou M.T. et al. Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan // Aging Clin. Exp. Res. 2019 Mar 14. doi: 10.1007/s40520-019- 01169-8.</mixed-citation><mixed-citation xml:lang="en">Lin C.J., Chang Y.C., Tsou M.T. et al. (2019 March 14). Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan. Aging Clin. Exp. Res. doi: 10.1007/ s40520-019-01169-8.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hamaguchi S., Suzuki M., Sasaki K. et al. Six underlying health conditions strongly infl uence mortality based on pneumonia severity in an ageing population of Japan: a prospective cohort study // BMC Pulm. Med. 2018. Vol. 18 (1): 88. doi: 10.1186/s12890-018-0648-y.</mixed-citation><mixed-citation xml:lang="en">Hamaguchi S., Suzuki M., Sasaki K. et al. (2018). Six underlying health conditions strongly infl uence mortality based on pneumonia severity in an ageing population of Japan: a prospective cohort study. BMC Pulm. Med., 18 (1), 88. doi: 10.1186/s12890-018- 0648-y.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Woodhead M., Blasi F., Ewig S. et al. Guidelines for the management of adult lower respiratory tract infections // Clin. Microbiol. Infect. 2011. Vol. 17 (6). E1–59.</mixed-citation><mixed-citation xml:lang="en">Woodhead M., Blasi F., Ewig S. et al. (2011). Guidelines for the management of adult lower respiratory tract infections. Clin. Microbiol. Infect., 17 (6), E1–59.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ходош Э.М., Потейко П.И., Ефремова О.А. Внебольничная пневмония: возможности и проблемы этиологической диагностики // Науч. ведомости Белгородского гос. ун-та. Серия: Медицина. Фармация. 2012. № 22 (141). С. 5–11.</mixed-citation><mixed-citation xml:lang="en">Khodosh E.M., Poteyko P.I., Efremova O.A. (2012). Community-acquired pneumonia: opportunities and problems of etiological diagnostics. Belgorod State University Scientifi c Bulletin. Series: Medicine. Pharmacy, 22 (141), 5–11. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г. Пневмония: актуальная проблема медицины XXI века // Пульмонология. 2015. Т. 25, № 2. С. 133–142.</mixed-citation><mixed-citation xml:lang="en">Chuchalin A.G. (2015). Pneumonia as an actual medical problem of the XXI century. Russian Pulmonology, 25, 2, 133–142. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Чигищев А.П. Особенности диагностики и оптимизация ведения пациентов с пневмонией // XXV Национальный конгресс по болезням органов дыхания: сб. трудов. М., 2015. С. 168–169.</mixed-citation><mixed-citation xml:lang="en">Chigishchev A.P. (2015). Features of diagnostics and optimization of managing patients with pneumonia. The XXV National Congress Of Respiratory Diseases. Moscow, pp. 168–169. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Зайцев А.А. Внебольничная пневмония: эпидемиология, диагностика и антимикробная терапия // Терапия. 2018. № 1 (19). С. 63–71.</mixed-citation><mixed-citation xml:lang="en">Zaytsev A.A. (2018). Community-acquired pneumonia: epidemiology, diagnostics and antimicrobic therapy. Therapy, 1 (19), 63–71. In Russ.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Голубев А.М., Смелая Т.В., Мороз В.В. и др. Внебольничная и нозокомиальная пневмония: клиникоморфологические особенности // Общая реаниматология. 2010. Т. 6, № 3. С. 5–14.</mixed-citation><mixed-citation xml:lang="en">Golubev A.M., Smelaya T.V., Moroz V.V. et al. (2010). Community-acquired and nosocomial pneumonia: clinical and morphological features. General Reanimatology, 6 (3), 5–14.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
