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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2019-4-98-108</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-596</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Способ прогнозирования риска развития инсульта у мужчин, работающих в условиях воздействия общей вибрации</article-title><trans-title-group xml:lang="en"><trans-title>A method for predicting the risk of stroke in men working under conditions of exposure to general vibration</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яшникова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yashnikova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яшникова Мария Викторовна — канд. мед. наук, ассистент кафедры неврологии</p><p>630091, г. Новосибирск, Красный просп., 52 </p></bio><bio xml:lang="en"><p>Yashnikova Maria Viktorovna — Cand. Sci. (Med.), Assistant of the Neurology Department</p><p>52, Krasny Prospect, Novosibirsk, 630091</p></bio><email xlink:type="simple">yash-maria@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потеряева</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Poteryaeva</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Потеряева Елена Леонидовна — д-р мед. наук, профессор, заведующий кафедрой неотложной терапии с эндокринологией и профпатологией</p><p>руководитель отдела медицины труда и промышленной экологии</p></bio><bio xml:lang="en"><p>Poteryaeva Elena Leonidovna — Dr. Sci. (Med.), Professor, Head of the Department of Emergency Therapy with Endocrinology and Occupational Pathology</p><p>Head of the Occupational Medicine and Industrial Ecology Department</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доронин</surname><given-names>Б. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Doronin</surname><given-names>B. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доронин Борис Матвеевич — д-р мед. наук, профессор, заведующий кафедрой неврологии</p></bio><bio xml:lang="en"><p>Doronin Boris Matveyevich — Dr. Sci. (Med.), Professor, Head of the Neurology Department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максимов Владимир Николаевич — д-р мед. наук, профессор кафедры медицинской генетики и биологии</p><p>заведующий лабораторией молекулярногенетических исследований терапевтических заболеваний</p></bio><bio xml:lang="en"><p>Maksimov Vladimir Nikolayevich — Dr. Sci. (Med.), Professor of the Medical Genetics and Biology Department</p><p>Head of the Laboratory of Molecular Genetic Studies of Internal Diseases</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чеканов</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chekanov</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чеканов Михаил Николаевич — д-р мед. наук, профессор кафедры общей хирургии</p></bio><bio xml:lang="en"><p>Chekanov Mikhail Nikolayevich — Dr. Sci. (Med.), Professor of the General Surgery Department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благитко</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Blagitko</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Благитко Евгений Михайлович — д-р мед. наук, профессор кафедры госпитальной и детской хирургии</p></bio><bio xml:lang="en"><p>Blagitko Evgeniy Mikhaylovich — Dr. Sci. (Med.), Professor of the Hospital and Pediatric Surgery Department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пешкова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Peshkova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пешкова Инесса Викторовна — д-р мед. наук, доцент кафедры анестезиологии и реаниматологии им. проф. И.П. Верещагина</p></bio><bio xml:lang="en"><p>Peshkova Inessa Viktorovna — Dr. Sci. (Med.), Associate Professor of the Anesthesiology and Intensive Care Department n.a. Prof. I.P. Vereshchagin</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смагин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Smagin</surname><given-names>A A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смагин Александр Анатольевич — д-р мед. наук, профессор, ведущий научный сотрудник лаборатории оперативной лимфологии и лимфодетоксикации</p></bio><bio xml:lang="en"><p>Smagin Aleksandr Anatolyevich — Dr. Sci. (Med.), Professor, Leading Researcher, Laboratory of Operative Lymphology and Lymphodetoxication</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; &#13;
ФБУН «Новосибирский научно-исследовательский институт гигиены» Роспотребнадзора России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University; &#13;
Novosibirsk Research Institute of Hygiene</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; &#13;
НИИ терапии и профилактической медицины — филиал ФГБУН «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University; &#13;
Research Institute of Internal and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>НИИ клинической и экспериментальной лимфологии — филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Clinical and Experimental Lymphology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>4</issue><fpage>98</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Яшникова М.В., Потеряева Е.Л., Доронин Б.М., Максимов В.Н., Чеканов М.Н., Благитко Е.М., Пешкова И.В., Смагин А.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Яшникова М.В., Потеряева Е.Л., Доронин Б.М., Максимов В.Н., Чеканов М.Н., Благитко Е.М., Пешкова И.В., Смагин А.А.</copyright-holder><copyright-holder xml:lang="en">Yashnikova M.V., Poteryaeva E.L., Doronin B.M., Maksimov V.N., Chekanov M.N., Blagitko E.M., Peshkova I.V., Smagin A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/596">https://jsms.elpub.ru/jour/article/view/596</self-uri><abstract><p>Целью исследования явилась разработка способа прогнозирования развития инсульта у мужчин, работающих в условиях воздействия общей вибрации. В обследование были включены 134 мужчины в возрасте от 30 до 65 лет, работавшие 5 и более лет по профессиям: водитель грузовой машины (БелАЗ-75, уровень общей вибрации — 80–116 дБ), водитель автобуса (уровень общей вибрации — 75–101 дБ). Участники исследования были разделены на две группы: первая — 70 мужчин, перенесших инсульт; вторая — 64 мужчины с диагнозом «Хроническая церебральная ишемия».</p><p>С помощью метода последовательного включения переменных (Forward Stepwise) были установлены факторы риска развития инсульта в исследуемой группе (возраст, стаж работы, уровень общего холестерина, прием гипотензивных препаратов, наличие в анамнезе фактора курения) и предложена формула логистической регрессии, позволяющая определять вероятность развития инсульта. Значение, равное или превышающее 0.6, получаемое при расчете по этой формуле, свидетельствует о высоком риске развития инсульта. Чувствительность предлагаемого метода составила 81.4 %, специфичность — 76.6 %. Предложенный метод прогнозирования развития инсульта у мужчин, работающих в условиях воздействия общей вибрации, может быть использован при проведении профилактических и периодических медицинских осмотров.</p><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.</p><p>Подана заявка в Роспатент № 2019116922. Дата приоритета 31.05.2019.</p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to develop a method for predicting the development of stroke in men working under conditions of exposure to general vibration. The survey included 134 men aged 30 to 65 years, who worked 5 or more years by occupation: truck driver (BelAZ-75, general vibration level — 80–116 dB), bus driver (general vibration level — 75–101 dB). The study participants were divided into two groups: the fi rst — 70 men who had a stroke; the second — 64 men with a diagnosis of chronic cerebral ischemia.</p><p>Using the method of successive inclusion of variables (Forward Stepwise), the risk factors for stroke in the study group (age, work experience, total cholesterol, taking antihypertensive drugs, the presence of a history of smoking factor) were established and a logistic regression formula was proposed that allows to determine the probability of stroke development. A value equal to or greater than 0.6 obtained by calculation using this formula indicates a high risk of stroke development. The sensitivity of the proposed method was 81.4%, specifi city — 76.6%. The proposed method for predicting the development of stroke in men working under conditions of exposure to general vibration can be used during preventive and periodic medical examinations.</p><sec><title>Conflict of interest</title><p>Conflict of interest. The authors declare no conflict of interest.</p></sec><sec><title>An application No</title><p>An application No. 2019116922 has been submitted to Rospatent. Priority date is 31.05.2019.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инсульт</kwd><kwd>мужчины</kwd><kwd>общая вибрация</kwd><kwd>риск развития инсульта</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stroke</kwd><kwd>men</kwd><kwd>general vibration</kwd><kwd>risk of stroke</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sanossian N., Obviagele В. Prevention and management of stroke in very elderly patients // Lancet Neurol. 2009. Vol. 8 (11). Р. 1031–1041.</mixed-citation><mixed-citation xml:lang="en">Sanossian N., Obviagele В. (2009). Prevention and management of stroke in very elderly patients. 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