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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2019-4-109-119</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-597</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Возможные факторы риска и предикторы развития пневмонии при коклюшной инфекции</article-title><trans-title-group xml:lang="en"><trans-title>Possible risk factors and predictors of pneumonia development in pertussis infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васюнин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyunin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васюнин Александр Васильевич — д-р мед. наук, профессор кафедры инфекционных болезней</p></bio><bio xml:lang="en"><p>Vasyunin Aleksandr Vasilyevich — Dr. Sci. (Med.), Professor of the Infectious Diseases Department</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Краснова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasnova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Краснова Елена Игоревна — д-р мед. наук, профессор, заведующий кафедрой инфекционных болезней</p></bio><bio xml:lang="en"><p>Krasnova Elena Igorevna — Dr. Sci. (Med.), Professor, Head of the Infectious Diseases Department,</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпович</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpovich</surname><given-names>G. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпович Глеб Сергеевич — ассистент кафедры инфекционных болезней</p><p>630091, г. Новосибирск, Красный просп., 52</p></bio><bio xml:lang="en"><p>Karpovich Gleb Sergeyevich — Teaching Assistant of the Infectious Diseases Department</p><p>52, Krasny Prospect, Novosibirsk, 630091</p></bio><email xlink:type="simple">karpovich.gleb@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Novosibirsk State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>4</issue><fpage>109</fpage><lpage>119</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васюнин А.В., Краснова Е.И., Карпович Г.С., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Васюнин А.В., Краснова Е.И., Карпович Г.С.</copyright-holder><copyright-holder xml:lang="en">Vasyunin A.V., Krasnova E.I., Karpovich G.S.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/597">https://jsms.elpub.ru/jour/article/view/597</self-uri><abstract><p>Проведено открытое, одноцентровое, ретроспективное исследование 418 историй болезни детей, наблюдавшихся по поводу коклюшной инфекции в ГБУЗ НСО «Детская городская клиническая больница № 3» (Новосибирск). Цель исследования — изучение особенностей осложненного пневмонией течения коклюшной инфекции и выявление вероятных факторов риска, а также клинико-лабораторных предикторов, способов профилактики осложненного пневмонией коклюша.</p><p>Анализ полученных результатов показал, что отсутствие вакцинации, отягощенный коморбидный фон и наличие искусственного вскармливания являются вероятными факторами риска осложненного коклюша, сочетание которых приводит к высокой частоте развития пневмонии при коклюше. Значительное увеличение частоты кашля, нарастание лейкоцитоза, нейтрофилеза на фоне течения коклюша следует считать предикторами развития пневмонии при коклюшной инфекции. Вакцинация — адекватный метод профилактики осложненной пневмонией коклюшной инфекции.</p><sec><title>Конфликт интересов</title><p>Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов.</p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><p>The open single center retrospective study of 418 case histories of children who were observed with pertussis infection in Novosibirsk Children’s City Clinical Hospital No. 3 was conducted. The objective of the research was to study characteristics of the course of pertussis infection complicated by pneumonia and to identify probable risk factors, as well as clinical laboratory predictors, ways of prevention of the pertussis complicated by pneumonia.</p><p>The analysis of the received results showed that absence of vaccination, the burdened comorbid background and the artificial feeding being the probable risk factors of the complicated pertussis, moreover, the combination of the above mentioned factors results in the high frequency of development of pertussis-associated pneumonia. The significant increase in frequency of cough, the rise in leukocytosis, neutrocytosis in the course of pertussis should be considered as predictors of the developing pneumonia. Vaccination is an adequate method of prevention of the pertussis infection complicated by pneumonia.</p><p>Conflict of interest. The authors declare no conflict of interest.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коклюш</kwd><kwd>осложненный коклюш</kwd><kwd>пневмония при коклюшной инфекции</kwd><kwd>лабораторные данные</kwd><kwd>вакцинация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pertussis</kwd><kwd>complicated pertussis</kwd><kwd>pneumonia in pertussis infection</kwd><kwd>laboratory data</kwd><kwd>vaccination</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Елькина И.А. Зависимость эпидемической обстановки по туберкулезу от ситуации по ВИЧинфекции в г. 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