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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2020-3-52-63</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-647</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Этиологическая и патоморфологическая характеристика врожденной пневмонии</article-title><trans-title-group xml:lang="en"><trans-title>Etiological and pathomorphological characteristics of congenital pneumonia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Надеев</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nadeev</surname><given-names>А. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Надеев Александр Петрович — д-р мед. наук, профессор, заведующий кафедрой патологической анатомии </p><p>630091, г. Новосибирск, Красный просп., 52</p></bio><bio xml:lang="en"><p>Nadeev Aleksandr Petrovich — Dr. Sci. (Med.), Professor, Head, Department of Pathological Anatomy </p><p>52, Krasny Prospect, Novosibirsk, 630091</p></bio><email xlink:type="simple">nadeevngma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpov</surname><given-names>M. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпов Михаил Александрович — канд. мед. наук, доцент кафедры патологической анатомии </p><p>Новосибирск </p></bio><bio xml:lang="en"><p>Karpov Mikhail Aleksandrovich — Cand. Sci. (Med.), Associate Professor, Department of Pathological Anatomy </p><p>Novosibirsk </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абышев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abyshev</surname><given-names>А. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абышев Александр Андреевич — аспирант кафедры патологической анатомии </p><p>Новосибирск </p></bio><bio xml:lang="en"><p>Abyshev Aleksandr Andreevich — Post-graduate Student, Department of Pathological Anatomy </p><p>Novosibirsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клочин</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Klochin</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клочин Виталий Дмитриевич — аспирант </p><p>Новосибирск </p></bio><bio xml:lang="en"><p>Klochin Vitaliy Dmitrievich — Post-graduate Student </p><p>Novosibirsk </p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овсянко</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovsyanko</surname><given-names>Е. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овсянко Елена Владимировна — д-р мед. наук, профессор кафедры анатомии человека им. акад. Ю.И. Бородина </p><p>Новосибирск </p></bio><bio xml:lang="en"><p>Ovsyanko Elena Vladimirovna — Dr. Sci. (Med.), Professor, Department of Human Anatomy named after Acad. Yu.I. Borodin </p><p>Novosibirsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>А. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Логинова Анастасия Борисовна — студентка IV курса лечебного факультета </p><p>Новосибирск </p></bio><bio xml:lang="en"><p>Loginova Anastasia Borisovna — 4th-year Student, Medical Faculty </p><p>Novosibirsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ляшенко</surname><given-names>С. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyashenko</surname><given-names>S. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ляшенко Светлана Леонидовна — ординатор кафедры патологической анатомии </p><p>Новосибирск </p></bio><bio xml:lang="en"><p>Lyashenko Svetlana Leonidovna — Resident, Department of Pathological Anatomy </p><p>Novosibirsk </p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России; ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University; Federal Research Center for Fundamental and Translational Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Fundamental and Translational Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>03</day><month>11</month><year>2020</year></pub-date><volume>0</volume><issue>3</issue><fpage>52</fpage><lpage>63</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Надеев А.П., Карпов М.А., Абышев А.А., Клочин В.Д., Овсянко Е.В., Логинова А.Б., Ляшенко С.Л., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Надеев А.П., Карпов М.А., Абышев А.А., Клочин В.Д., Овсянко Е.В., Логинова А.Б., Ляшенко С.Л.</copyright-holder><copyright-holder xml:lang="en">Nadeev А.P., Karpov M.А., Abyshev А.А., Klochin V.D., Ovsyanko Е.V., Loginova А.B., Lyashenko S.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/647">https://jsms.elpub.ru/jour/article/view/647</self-uri><abstract><p>С целью изучения этиологических факторов и патоморфологических изменений лёгких при врожденной пневмонии у детей исследовано 80 историй болезней и протоколов патолого-анатомических вскрытий умерших детей, поступивших в патологоанатомические отделения многопрофильных детских стационаров г. Новосибирска за 2018–2019 гг. Оценивались такие данные, как пол, возраст, доношенность, данные прижизненного и посмертного бактериологических исследований, а также результаты гистологического исследования внутренних органов и, учитывая неразрывность системы мать — плацента — плод и роль печени как барьерного органа при перинатальных инфекциях, плаценты и печени. Выявлено, что летальные исходы вследствие врожденной пневмонии чаще наблюдаются у мальчиков и преимущественно у недоношенных детей. Врожденная пневмония в большинстве случаев являлась частью генерализованного инфекционного процесса (неонатальный сепсис, внутриутробная инфекция) (до 85 %), с частым поражением кишечника (энтероколит), печени (фетальный гепатит). Основные этиологические факторы врожденной пневмонии — Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli или бактериальнобактериальные ассоциации с теми же возбудителями. В морфологической картине лёгких преобладала интерстициально-десквамативная пневмония.</p></abstract><trans-abstract xml:lang="en"><p>In order to study the etiological factors and pathomorphological changes in lungs in congenital pneumonia, 80 case histories and autopsy records of deceased children who were admitted to the pathological departments of multidisciplinary children’s hospitals in Novosibirsk in 2018–2019 were analyzed. Such parameters as gender, age, maturity, data from intravital and postmortem bacteriological tests, as well as the results of histological examination of internal organs and, taking into account the continuity of the mother — placenta — fetus system and the role of the liver as a barrier organ in perinatal infections, placenta and liver, were assessed. It was found that fatal outcomes due to congenital pneumonia are more often observed in boys, and mainly in premature newborn infants. Congenital pneumonia in most cases was part of a generalized infectious process (neonatal sepsis, intrauterine infection) (up to 85%), with frequent damage to the intestine (enterocolitis), liver (fetal hepatitis). The main etiological factors of congenital pneumonia are Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli or bacterial-bacterial associations of the above pathogens. The morphological picture of the lungs was dominated by desquamative interstitial pneumonia.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>врожденная пневмония</kwd><kwd>неонатальный сепсис</kwd><kwd>этиология</kwd><kwd>патологическая анатомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>congenital pneumonia</kwd><kwd>neonatal sepsis</kwd><kwd>etiology</kwd><kwd>pathological anatomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">McAllister D.A., Liu L., Shi T. et al. 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