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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-693</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Клинико-динамические особенности течения биполярного аффективного расстройства, коморбидного с синдромом зависимости от употребления каннабиоидов</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and dynamic features of the course of bipolar affective disorder comorbid with cannabinoid addiction syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климова</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimova</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Климова Ирина Юрьевна — ассистент кафедры психиатрии, наркологии, психотерапии и клинической психологии.</p><p>630091, Новосибирск, Красный просп., 52</p></bio><bio xml:lang="en"><p>Klimova Irina Yuryevna — Assistant, Department of Psychiatry, Narcology, Psychotherapy and Clinical Psychology.</p><p>52, Krasny Prospect, Novosibirsk, 630091</p></bio><email xlink:type="simple">iri.c2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчинников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovchinnikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овчинников Анатолий Александрович — доктор медицинских наук, профессор, заведующий кафедрой психиатрии, наркологии, психотерапии и клинической психологии.</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Ovchinnikov Anatoly Aleksandrovich — Dr. Sci. (Med.), Professor, Head, Department of Psychiatry, Narcology, Psychotherapy and Clinical Psychology.</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпушкин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpushkin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпушкин Александр Михайлович — ассистент кафедры психиатрии, наркологии, психотерапии и клинической психологии.</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Karpushkin Aleksandr Mikhaylovich — Assistant, Department of Psychiatry, Narcology, Psychotherapy and Clinical Psychology.</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Новосибирский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>11</day><month>04</month><year>2021</year></pub-date><volume>0</volume><issue>4</issue><fpage>46</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Климова И.Ю., Овчинников А.А., Карпушкин А.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Климова И.Ю., Овчинников А.А., Карпушкин А.М.</copyright-holder><copyright-holder xml:lang="en">Klimova I.Y., Ovchinnikov A.A., Karpushkin A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/693">https://jsms.elpub.ru/jour/article/view/693</self-uri><abstract><p>В исследование, посвященное клинико-динамическим особенностям течения биполярного аффективного расстройства (БАР), коморбидного с синдромом зависимости от употребления каннабиоидов, были включены 104 пациента в возрасте от 23 до 28 лет (средний возраст 25.19 ± 1.74 года). Все участники исследования были разделены на две группы: в 1-ю, основную вошли 54 респондента с клинически установленным диагнозом БАР (F31 по МКБ-10), коморбидным с синдромом зависимости от употребления каннабиоидов (F12.2 по МКБ-10), с началом употребления каннабиоидов после установления диагноза БАР; 2-я группа, контрольная состояла из 50 пациентов с клинически установленным диагнозом БАР (F31 по МКБ-10). Длительность заболевания в обеих группах — более 3 лет. Все пациенты, включенные в исследование, получали адекватную психофармакотерапию.</p><p>В основной группе отсутствие симптомов депрессии отмечалось в 63 % случаев, низкий уровень тревоги — в 29 % случаев, продолжительность ремиссии свыше 2 мес — в 39 % случаев. Было отмечено уменьшение интенсивности таких симптомов, как грусть, тоска, подавленность. Кроме того, 74 % респондентов основной группы указывали на нормализацию сна, более 60 % — на стабилизацию эмоционального фона, 81 % — на нормализацию аппетита и прибавку в весе. Анализируя полученные результаты, можно предположить, что употребление канна-биоидов у лиц с БАР парадоксальным образом смягчает определенные симптомы заболевания, что нуждается в дальнейшем обсуждении и исследовании.</p></abstract><trans-abstract xml:lang="en"><p>The study devoted to the clinical and dynamic features of the course of bipolar affective disorder (BPAD) comorbid with cannabinoid dependence syndrome included 104 patients aged 23 to 28 years (mean age 25.19 ± 1.74 years). All study participants were divided into two groups: the first, main group included 54 respondents with a clinically proven BPAD diagnosis (F31 according to ICD-10) comorbid with cannabinoid dependence syndrome (F12.2 according to ICD-10) with the onset of use of cannabinoids after the BPAD diagnosis; the second, control group consisted of 50 patients with clinically proven BPAD diagnosis (F31 according to ICD-10). The duration of the disease in both groups is more than 3 years. All patients included in the study received adequate psychopharmacotherapy.</p><p>In the main group, the absence of symptoms of depression was noted in 63% of cases, a low level of anxiety — in 29% of cases, the duration of remission over 2 months — in 39% of cases. A decrease in the intensity of symptoms such as sadness, melancholy, despondency was noted. In addition, 74% of the main group respondents looked to normalization of sleep, more than 60% — stabilization of the emotional background, 81% — appetite enhancement and weight gain. Analyzing the obtained results, it can be assumed that the use of cannabinoids in individuals with BPAD paradoxically alleviates certain symptoms of the disease, which requires further discussion and research.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>биполярное аффективное расстройство</kwd><kwd>каннабиоидная наркомания</kwd><kwd>депрессия</kwd><kwd>тревога</kwd><kwd>эмоциональная лабильность</kwd><kwd>прогноз</kwd><kwd>ремиссия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bipolar affective disorder</kwd><kwd>cannabinoid addiction</kwd><kwd>depression</kwd><kwd>anxiety</kwd><kwd>emotional lability</kwd><kwd>prognosis</kwd><kwd>remission</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аведисова А.С., Воробьев Р.В. Типология смешанных депрессивных состояний в клинике биполярного аффективного расстройства // Журн. неврологии и психиатрии им. С.С. 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