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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-698</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Характер и динамика изменений в фасеточных суставах при различной степени дегенерации межпозвоночных дисков</article-title><trans-title-group xml:lang="en"><trans-title>The nature and dynamics of the facet joints changes in varying grades of intervertebral disc degeneration</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конев</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Konev</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Конев Владимир Павлович — доктор медицинских наук, профессор, заведующий кафедрой судебной медицины и правоведения.</p><p>644099, Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Konev Vladimir Pavlovich — Dr. Sci. (Med.), Professor, Head, Department of Forensic Medicine and Law.</p><p>12, Lenina str., Omsk, 644099</p></bio><email xlink:type="simple">vpkonev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кривошеин</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Krivoshein</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кривошеин Артем Евгеньевич — кандидат медицинских наук, доцент кафедры травматологии и ортопедии ОГМУ; научный руководитель отделения травматологии № 2 (вертебрологии) БУЗОО «Клинический МЦ МЗ Омской области.</p><p>Омск</p></bio><bio xml:lang="en"><p>Krivoshein Artem Evgenyevich — Cand. Sci. (Med.), Assistant Professor, Department of Traumatology and Orthopedics, OSMU; Scientific Director, Department of Traumatology No. 2 (Verte-brology), CMSC.</p><p>Omsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колесов Сергей Васильевич — доктор медицинских наук, профессор, заведующий отделением патологии позвоночника.</p><p>Москва</p></bio><bio xml:lang="en"><p>Kolesov Sergey Vasilyevich — Dr. Sci. (Med.), Professor, Head, Department of Spine Pathology.</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Московский</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Moscovsky</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Московский Сергей Николаевич — кандидат медицинских наук, доцент кафедры судебной медицины и правоведения.</p><p>Омск</p></bio><bio xml:lang="en"><p>Moscovsky Sergey Nikolayevich — Candidate Sci. (Med.), Assistant Professor, Department of Forensic Medicine and Law.</p><p>Omsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Омский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Омский государственный медицинский университет Минздрава России; БУЗОО Клинический медико-хирургический центр Министерства здравоохранения Омской области</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Omsk State Medical University; Clinical Medical and Surgical Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Priorov National Medical Research Center of Traumatology and Orthopedics</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>11</day><month>04</month><year>2021</year></pub-date><volume>0</volume><issue>4</issue><fpage>90</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Конев В.П., Кривошеин А.Е., Колесов С.В., Московский С.Н., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Конев В.П., Кривошеин А.Е., Колесов С.В., Московский С.Н.</copyright-holder><copyright-holder xml:lang="en">Konev V.P., Krivoshein A.E., Kolesov S.V., Moscovsky S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/698">https://jsms.elpub.ru/jour/article/view/698</self-uri><abstract><p>Исследовались биопсийные материалы 145 пациентов, которым после комплексного клинико-инструментального исследования, с учетом степени дегенерации межпозвоночных дисков по Pfirrmann, проведены декомпрессивно-стабилизирующие вмешательства на поясничном отделе позвоночника, с полной или частичной фасетэктомией на уровне поражения. Все исследуемые биопсийные материалы были разделены на 4 группы в зависимости от степени дегенерации межпозвоночного диска по Pfirrmann у пациента: группа 1 — II степень (ст.) дегенерации (n = 31); группа 2 — III ст. (n = 36); группа 3 — IV ст. (n = 46); группа 4 — V ст. (n = 32).</p><p>Установлено увеличение объемного содержания хондроцитов в промежуточной зоне. Возрастание клеточной плотности связано с увеличением доли 3- и 4-клеточных лакун и появлением 4-6-клеточных скоплений на поздних стадиях дегенерации диска. При этом объемное содержание хондроцитов в поверхностной зоне значительно снижалось.</p><p>Выявленные характер и динамика изменений в фасеточных суставах могут использоваться при интерпретации результатов нейровизуализации для более обоснованного выбора методик фиксации позвоночно-двигательного сегмента при дегенеративных заболеваниях поясничного отдела позвоночника.</p></abstract><trans-abstract xml:lang="en"><p>Biopsy materials from 145 patients were studied. All patients after a comprehensive clinical and instrumental examination, taking into account the grade of intervertebral disk degeneration according to Pfirrmann, underwent decompression and stabilization interventions on the lumbar spine, with a complete or partial facetectomy at the level of the lesion. All examined biopsy materials were divided into 4 groups depending on the grade of intervertebral disk degeneration according to Pfir-rmann: group 1 — grade II (n = 31); group 2 — grade III (n = 36); group 3 — grade IV (n = 46); group 4 — grade V (n = 32).</p><p>An increase in volume fraction of chondrocytes in intermediate zone was established. The cellular density growth was associated with an increase in the proportion of 3- and 4-cell lacunae and the emergence of 4-6 cell clusters at the advanced stages of disk degeneration. At the same time, the chondrocyte volume fraction in the superficial zone decreased significantly.</p><p>The revealed nature and dynamics of changes in the facet joints can be used in the interpretation of neuroimaging results for more reasonable choice of fixation techniques of a spinal motion segment in degenerative diseases of lumbar spine.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дегенерация</kwd><kwd>фасеточный сустав</kwd><kwd>межпозвоночный диск</kwd><kwd>Pfirrmann</kwd></kwd-group><kwd-group xml:lang="en"><kwd>degeneration</kwd><kwd>facet joint</kwd><kwd>intervertebral disk</kwd><kwd>Pfirrmann</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Макиров С.К., Юз А.А., Джахаф М.Т., Гусев С.С. Современные возможности задней динамической стабилизации позвоночника в профилактике синдрома смежного уровня: обзор литературы // Хирургия позвоночника. 2015. 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