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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">jsms-721</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Рак (краткий обзор)</article-title><trans-title-group xml:lang="en"><trans-title>Cancer at a glance</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мимун</surname><given-names>Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mimoune</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мимун Нура — Ph.D., H.D.R., доцент, старший преподаватель Национальной высшей школы ветеринарии; научный сотрудник лаборатории биотехнологий репродукции животных Института ветеринарии</p><p>РВ 270, г. Блида</p></bio><bio xml:lang="en"><p>Mimoune Nora — Ph.D., H.D.R., Senior Lecturer, Associate Professor, National High School of Veterinary Medicine; Permanent Researcher, Laboratory of Biotechnologies related to Animal Reproduction, Institute of Veterinary Sciences, University of Blida 1</p><p>РВ 270, Blida</p></bio><email xlink:type="simple">nora.mimoune@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баху</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bahouh</surname><given-names>M. W.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баху Мухамед Вайль — д-р ветеринарии, магистр Национальной высшей школы ветеринарии</p><p>Баб-Эззуар</p></bio><bio xml:lang="en"><p>Bahouh Mohamed Wail — D.V.M., M.S., National High School of Veterinary Medicine</p><p>Algeria</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Букхекем</surname><given-names>С.</given-names></name><name name-style="western" xml:lang="en"><surname>Boukhechem</surname><given-names>S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Букхекем Саид — Ph.D., H.D.R., доцент, старший преподаватель</p><p>Эль-Хруб</p></bio><bio xml:lang="en"><p>Boukhechem Said — Ph.D., H.D.R., Senior Lecturer, Associate Professor</p><p>El-Khroub, Constantine</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маруф</surname><given-names>Н. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Marouf</surname><given-names>N. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маруф Нуфель Уайль — д-р ветеринарии, магистр</p><p>Баб-Эззуар</p></bio><bio xml:lang="en"><p>Marouf Noufel Ouail — D.V.M., M.S.</p><p>Algiers, Bab-Ezzouar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Келеф</surname><given-names>Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Khelef</surname><given-names>D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Келеф Джамель — Ph.D., H.D.R., профессор</p><p>Баб-Эззуар</p></bio><bio xml:lang="en"><p>Khelef Djamel — Ph.D., H.D.R., Full Professor</p><p>Algiers, Bab-Ezzouar</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каиди</surname><given-names>Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaidi</surname><given-names>R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каиди Рашид — Ph.D., H.D.R., профессор</p><p> </p></bio><bio xml:lang="en"><p>Kaidi Rachid — Ph.D., H.D.R., Full Professor</p><p> </p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальная высшая школа ветеринарии;&#13;
ЛБРЖ, Институт ветеринарии, Университет Блиды 1</institution><country>Алжир</country></aff><aff xml:lang="en"><institution>National High School of Veterinary Medicine;&#13;
LBRA, Institute of Veterinary Sciences, University of Blida 1</institution><country>Algeria</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальная высшая школа ветеринарии</institution><country>Алжир</country></aff><aff xml:lang="en"><institution>National High School of Veterinary Medicine</institution><country>Algeria</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Национальный институт ветеринарии</institution><country>Алжир</country></aff><aff xml:lang="en"><institution>National Veterinary Institute</institution><country>Algeria</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ЛБРЖ, Институт ветеринарии, Университет Блиды 1</institution><country>Алжир</country></aff><aff xml:lang="en"><institution>LBRA, Institute of Veterinary Sciences, University of Blida 1</institution><country>Algeria</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>22</day><month>08</month><year>2021</year></pub-date><volume>0</volume><issue>2</issue><fpage>77</fpage><lpage>103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мимун Н., Баху М.В., Букхекем С., Маруф Н.У., Келеф Д., Каиди Р., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Мимун Н., Баху М.В., Букхекем С., Маруф Н.У., Келеф Д., Каиди Р.</copyright-holder><copyright-holder xml:lang="en">Mimoune N., Bahouh M.W., Boukhechem S., Marouf N.O., Khelef D., Kaidi R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/721">https://jsms.elpub.ru/jour/article/view/721</self-uri><abstract><p>Термином «рак» обозначают злокачественные опухоли различного типа. Каждый из этих типов классифицируется в зависимости от ткани, из которой развивается опухоль. Рак возникает вследствие неконтролируемого деления клеток, которые занимают место здоровых клеток. Летальность при раке, в основном, является результатом повреждений, вызванных метастазами. Вот почему крайне важно диагностировать заболевание на ранней стадии, прежде чем появятся метастазы. После постановки диагноза начинается лечение рака: оно предполагает использование различных методов, применение которых координируется на протяжении всего курса лечения. Ответ опухоли на терапию может быть различным. Одни виды рака лучше лечатся с помощью хирургических методов, другие восприимчивы к химиотерапии. Нередко для достижения наилучшего результата необходимо одновременное использование нескольких методов терапии. Исследования в области онкологии до настоящего времени в большинстве своем были посвящены раковой клетке как таковой. Актуальной задачей на современном этапе представляется понимание того, как эта клетка взаимодействует со своим ближайшим окружением. Какие процессы она приводит в действие, чтобы ускользнуть от иммунной системы, либо, напротив, успешно диссеминировать? Понимание этих механизмов может привести к созданию новых эффективных методов лечения.</p></abstract><trans-abstract xml:lang="en"><p>Cancer is a generic term that groups different types of malignant tumors. Each of them has a specific name according to the tissue that gave birth to it. It appears when cells multiply in an uncontrolled manner and take the place of healthy cells. Deaths from cancer are mainly due to damage caused by metastases. This is why it is important to diagnose the disease early, before it spreads in the body. After the diagnosis announcement, cancer management is put in place: it involves several treatments that are articulated throughout the course of care. Cancers have the particularity of reacting differently to treatments. Some types of cancer are best treated with surgery. Others respond better to drugs called chemotherapy. It often happens that several treatments are administered together to ensure the best possible results. Studies have so far focused largely on the tumor cell itself. The new challenge for researchers is now to understand how these cells interact with their immediate environment. What processes do they put in place to escape the immune system or to successfully spread? Understanding these mechanisms could lead to the development of new types of treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак</kwd><kwd>ДНК</kwd><kwd>генетика</kwd><kwd>онкогенез</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cancer</kwd><kwd>DNA</kwd><kwd>genetic</kwd><kwd>oncogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cavenee W., White R. Anomalies génétiques et cancers // Pour la Science. 1995. Vol. 211. P. 60–68.</mixed-citation><mixed-citation xml:lang="en">Cavenee W., White R. (1995). Anomalies génétiques et cancers. Pour la Science, 211, 60–68.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Paul S., Régulier E. Bases moléculaires de l’oncogеnèse// Ann. Biol. Clin. 2001. Vol. 59. P. 393–402.</mixed-citation><mixed-citation xml:lang="en">Paul S., Régulier E. (2001). Bases moléculaires de l’oncogеnèse. Ann. Biol. Clin., 59, 393–402.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Favrot M.C. La cellule cancéreuse // Rev. Prat. 1997. Vol. 47. P. 1029–1036.</mixed-citation><mixed-citation xml:lang="en">Favrot M.C. (1997). La cellule cancéreuse. Rev. Prat., 47, 1029–1036.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Diaz-Cano S.J. General morphological and biological features of neoplasms: integration of molecular findings // Histopathology. 2008. Vol. 53. P. 1–19.</mixed-citation><mixed-citation xml:lang="en">Diaz-Cano S.J. (2008). General morphological and biological features of neoplasms: integration of molecular findings. Histopathology, 53, 1–19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Azzouz M.Y., Mimoune N., Kaidi R. Les Tumeurs Utérines Chez la Femme, Notions Classiques et Nouvelles. Presses Académiques Francopohones, 2020.</mixed-citation><mixed-citation xml:lang="en">Azzouz M.Y., Mimoune N., Kaidi R. (2020). Les Tumeurs Utérines Chez la Femme, Notions Classiques et Nouvelles. Presses Académiques Francopohones.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ferlay J., Soerjomataram I., Ervik M., Dikshit R. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancer base No. 11 [Internet]. International Agency for Research on Cancer. Lyon, France. 2013.</mixed-citation><mixed-citation xml:lang="en">Ferlay J., Soerjomataram I., Ervik M., Dikshit R. (2013). GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC cancer base No. 11 [Internet]. International Agency for Research on Cancer. Lyon, France.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Scotté F., Colonna P., AndrieU J.-M. Cancérologie. Nouvelle édition. Paris: Ellipses, 2008.</mixed-citation><mixed-citation xml:lang="en">Scotté F., Colonna P., AndrieU J.-M. (2008). Cancérologie. Nouvelle édition. Paris: Ellipses.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Davies P.C., Lineweaver C. Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors // Physical Biol. 2011. Vol. 8 (1): 015001.</mixed-citation><mixed-citation xml:lang="en">Davies P.C., Lineweaver C. (2011). Cancer tumors as Metazoa 1.0: tapping genes of ancient ancestors. Physic. Biol., 8 (1), 015001.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">National Cancer Institute. About cancer. URL: https://www.cancer.gov/about-cancer/understanding/whatis-cancer. Дата обращения: 26.03.2021.</mixed-citation><mixed-citation xml:lang="en">National Cancer Institute. About cancer (2015). Retrieved on March 26, 2021 from https://www.cancer.gov/about-cancer/understanding/what-is-cancer.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">WHO. Cancer. URL: https://www.who.int/newsroom/fact-sheets/detail/cancer. Дата обращения: 26.03.2021.</mixed-citation><mixed-citation xml:lang="en">WHO. Cancer (2018). Retrieved on March 26, 2021 from https://www.who.int/news-room/fact-sheets/detail/cancer.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gaspar T., Hagège D., Kevers C., Penel C. When plant teratomas turn into cancers in the absence of pathogens // Physiologia Plantarum. 1991. Vol. 83. P. 696–701.</mixed-citation><mixed-citation xml:lang="en">Gaspar T., Hagège D., Kevers C., Penel C. (1991). When plant teratomas turn into cancers in the absence of pathogens. Physiologia Plantarum, 83, 696–701.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Doonan J., Hunt T. Why don’t plants get cancer? // Nature. 1996. Vol. 380 (6574). P. 481–482.</mixed-citation><mixed-citation xml:lang="en">Doonan J., Hunt T. (1996). Why don’t plants get cancer? Nature, 380 (6574), 481–482.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rothschild B.M., Tanke D.H., Helbling M. Epidemiologic study of tumors in dinosaurs // Naturwissenschaften. 2003. Vol. 90 (11). P. 495–500.</mixed-citation><mixed-citation xml:lang="en">Rothschild B.M., Tanke D.H., Helbling M. (2003). Epidemiologic study of tumors in dinosaurs. Naturwissenschaften, 90 (11), 495–500.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Geoffrey C. The Cell: A Molecular Approach. 2nd еd., Sinauer Associates Inc., 2000.</mixed-citation><mixed-citation xml:lang="en">Geoffrey C. (2000). The Cell: A Molecular Approach. 2nd ed., Sinauer Associates Inc.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Clarke B.B. Historical review of the causes of cancer // World J. Clin. Oncol. 2016. Vol. 7 (1). P. 54–86.</mixed-citation><mixed-citation xml:lang="en">Clarke B.B. (2016). Historical review of the causes of cancer. World J. Clin. Oncol., 7 (1), 54–86.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Tessitore A., Cicciarelli G., Del Vecchio F. et al. MicroRNAs in the DNA damage/repair network and cancer // Int. J. Genom. 2014: 820248.</mixed-citation><mixed-citation xml:lang="en">Tessitore A., Cicciarelli G., Del Vecchio F. et al. (2014). MicroRNAs in the DNA damage/repair network and cancer. Int. J. Genom., 820248.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sibransky D. Emerging molecular markers of cancer // Nat. Rev. Сancer. 2002. Vol. 2 (3). P. 210–219.</mixed-citation><mixed-citation xml:lang="en">David S. (2002). Emerging molecular markers of cancer. Nat. Rev. Cancer, 2 (3), 210–219.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Stratton M., Campbell P., Futreal P. The cancer genome // Nature. 2009. Vol. 458 (7239). P. 719–724.</mixed-citation><mixed-citation xml:lang="en">Stratton M., Campbell P., Futreal P. (2009). The cancer genome. Nature, 458 (7239), 719–724.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Croce C.M. Oncogenes and cncer // N. Engl. J. Med. 2008. Vol. 358 (5). P. 502–511.</mixed-citation><mixed-citation xml:lang="en">Croce C.M. (2008). Oncogenes and cancer. N. Engl. J. Med., 358 (5), 502–511.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sarkar S., Horn G., Moulton K. et al. Cancer development, progression, and therapy: an epigenetic overview // Int. J. Mol. Sci. 2013. Vol. 14 (10). P. 21087– 21113.</mixed-citation><mixed-citation xml:lang="en">Sarkar S., Horn G., Moulton K. et al. (2013). Cancer development, progression, and therapy: an epigenetic overview. Int. J. Mol. Sci., 14 (10), 21087–21113.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Levine A., Momand J., Finlay C. The p53 tumour suppressor gene // Nature. 1991. Vol. 351 (6326). P. 453– 456.</mixed-citation><mixed-citation xml:lang="en">Levine A., Momand J., Finlay C. (1991). The p53 tumour suppressor gene. Nature, 351 (6326), 453–456.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Peng Y., Croce C. The role of MicroRNAs in human cancer // Sign. Transduct. Targ. Ther. 2016. Vol. 1: 15004.</mixed-citation><mixed-citation xml:lang="en">Peng Y., Croce C. (2016). The role of MicroRNAs in human cancer. Sign. Transduct. Targ. Ther., 1, 15004.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Buder T., Deutsch A., Klink B., Voss-Böhme A. Patterns of tumor progression predict small and tissue-specifi c tumor-originating niches // Front. Oncol. 2019. Vol. 8: 668.</mixed-citation><mixed-citation xml:lang="en">Buder T., Deutsch A., Klink B. et al. (2019). Patterns of tumor progression predict small and tissue-specific tumor-originating niches. Front. Oncol., 8, 668.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Egeblad M., Nakasone E.S., Werb Z. Tumors as organs: complex tissues that interface with the entire organism // Develop. Сell. 2010. Vol. 18 (6). P. 884–901.</mixed-citation><mixed-citation xml:lang="en">Egeblad M., Nakasone E.S., Werb Z. (2010). Tumors as organs: complex tissues that interface with the entire organism. Develop. Cell, 18 (6), 884–901.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Siddiqui I., Sanna V., Ahmad N., Sechi M., Mukhtar H. Resveratrol nanoformulation for cancer prevention and therapy // Ann. N.Y. Acad. Sci. 2015. Vol. 1348 (1). P. 20–31.</mixed-citation><mixed-citation xml:lang="en">Siddiqui I., Sanna V., Ahmad N., Sechi M. (2015). Resveratrol nanoformulation for cancer prevention and therapy. Ann. N.Y. Acad. Sci., 1348 (1), 20–31.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Seyfried T.N., Huysentruyt L.C. On the origin of cancer metastasis // Crit. Rev. Oncogen. 2013. Vol. 18 (1–2). P. 43–73.</mixed-citation><mixed-citation xml:lang="en">Seyfried T.N., Huysentruyt L.C. (2013). On the origin of cancer metastasis. Crit. Rev. Oncogen., 18 (1–2), 43–73.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Qian C.-N., Mei Y., Zhang J. Cancer metastasis: issues and challenges // Chin. J. Cancer. 2017. Vol. 36 (1): 38.</mixed-citation><mixed-citation xml:lang="en">Qian C.-N., Mei Y., Zhang J. (2017). Cancer metastasis: issues and challenges. Chin. J. Cancer, 36 (1), 38.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fares J., Fares M.Y., Khachfe H.H., Salhab H.A., Fares Y. Molecular principles of metastasis: a hallmark of cancer revisited // Sign. Transduct. Targ. Ther. 2020. Vol. 5 (1): 28.</mixed-citation><mixed-citation xml:lang="en">Fares J., Fares M.Y., Khachfe H.H., Salhab H.A., Fares Y. (2020). Molecular principles of metastasis: a hall mark of cancer revisited. Sign. Transduct. Targ. Ther., 5 (1), 28.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wang R.-A., Lu Y.-Y., Fan D.-M. Reasons for cancer metastasis: A holistic perspective // Mol. Clin. Oncol. 2015. Vol. 3 (6). P. 1199–1202.</mixed-citation><mixed-citation xml:lang="en">Wang R.-A., Lu Y.-Y., Fan D.-M. (2015). Reasons for cancer metastasis: A holistic perspective. Mol. Clin. Oncol., 3 (6), 1199–1202.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bakhoum S.F., Ngo B., Laughney A.M. et al. Chromosomal instability drives metastasis through a cytosolic DNA response // Nature. 2018. Vol. 553 (7689). P. 467–472.</mixed-citation><mixed-citation xml:lang="en">Bakhoum S.F., Ngo B., Laughney A.M. et al. (2018). Chromosomal instability drives metastasis through a cytosolic DNA response. Nature, 553 (7689), 467–472.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Vinay D.S., Ryan E.P., Pawelec G. et al. Immune evasion in cancer: Mechanistic basis and therapeutic strategies // Semin. Cancer Biol. 2015. Vol. 35. P. S185– S198.</mixed-citation><mixed-citation xml:lang="en">Vinay D.S., Ryan E.P., Pawelec G. et al. (2015). Immune evasion in cancer: Mechanistic basis and therapeutic strategies. Semin. Cancer Biol., 35, S185–S198.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gonzalez H., Hagerling C., Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression // Genes Dev. 2018. Vol. 32 (19–20). P. 1267–1284.</mixed-citation><mixed-citation xml:lang="en">Gonzalez H., Hagerling C., Werb Z. (2018). Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev., 32 (19–20), 1267– 1284.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Brown T. Genomes. 2nd ed. London: Oxford: WileyLiss, 2002.</mixed-citation><mixed-citation xml:lang="en">Brown T. (2002). Genomes. 2nd ed. London: Oxford: Wiley-Liss.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ucker D.S., Levine J.S. Exploitation of apoptotic regulation in cancer // Front. Immunol. 2018. Vol. 9: 241.</mixed-citation><mixed-citation xml:lang="en">Ucker D.S., Levine J.S. (2018). Exploitation of apoptotic regulation in cancer. Front. Immunol., 9, 241.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">National Cancer Institute. How Cancer Is Diagnosed (2019). URL: https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis. Дата обращения: 26.03.2021.</mixed-citation><mixed-citation xml:lang="en">National Cancer Institute. How Cancer Is Diagnosed (2019). Retrieved on March 26, 2021 from https://www.cancer.gov/about-cancer/diagnosis-staging/diagnosis.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ziv E., Durack J.C., Solomon S.B. The importance of biopsy in the era of molecular medicine // Cancer J. 2016. Vol. 22 (6). P. 418–422.</mixed-citation><mixed-citation xml:lang="en">Ziv E., Durack J.C., Solomon S.B. (2016). The importance of biopsy in the era of molecular medicine. Cancer J., 22 (6), 418–422.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Marshall D., Laberge J.M., Firetag B., Miller T., Kerlan R.K. The changing face of percutaneous image-guided biopsy: molecular profiling and genomic analysis in current practice // J. Vasc. Interv. Radiology. 2013. Vol. 24 (8). P. 1094–1103.</mixed-citation><mixed-citation xml:lang="en">Marshall D., Laberge J.M., Firetag B., Miller T., Kerlan R.K. (2013). The changing face of percutaneous imageguided biopsy: molecular profiling and genomic analysis in current practice. J. Vasc. Interv. Radiology, 24 (8), 1094–1103.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Palmirotta R., Lovero D., Cafforio P. et al. Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology // Ther. Adv. Med. Oncol. 2018. Vol. 10. P. 1–24.</mixed-citation><mixed-citation xml:lang="en">Palmirotta R., Lovero D., Cafforio P. et al. (2018). Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology. Ther. Adv. Med. Oncol., 10, 1–24.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Alix-Panabières C. The future of liquid biopsy // Nature. 2020. Vol. 579 (7800): S9.</mixed-citation><mixed-citation xml:lang="en">Alix-Panabières C. (2020). The future of liquid biopsy. Nature, 579 (7800), S9.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Brierley J., Gospodarowicz M., O’Sullivan B. The principles of cancer staging // еСancer. 2016. Vol. 10: ed61.</mixed-citation><mixed-citation xml:lang="en">Brierley J., Gospodarowicz M., O’Sullivan B. (2016). The principles of cancer staging. eCancer, 10, ed61.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Arruebo M., Vilaboa N., Sáez-Gutierrez B. et al. Assessment of the evolution of cancer treatment therapies // Cancers. 2011. Vol. 3 (3). P. 3279–3330.</mixed-citation><mixed-citation xml:lang="en">Arruebo M., Vilaboa N., Sáez-Gutierrez B. et al. (2011). Assessment of the evolution of cancer treatment therapies. Cancers, 3 (3), 3279–3330.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Falzone L., Salomone S., Libra M. Evolution of cancer pharmacological treatments at the turn of the third millennium // Front. Pharmacol. 2018. Vol. 9: 1300.</mixed-citation><mixed-citation xml:lang="en">Falzone L., Salomone S., Libra M. (2018). Evolution of cancer pharmacological treatments at the turn of the third millennium. Front. Pharmacol., 9, 1300.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Baskar R., Lee K.A., Yeo R., Yeoh K.-W. Cancer and radiation therapy: current advances and future directions // Int. J. Med. Sci. 2012. Vol. 9 (3). P. 193–199.</mixed-citation><mixed-citation xml:lang="en">Baskar R., Lee K.A., Yeo R., Yeoh K.W. (2012). Cancer and radiation therapy: current advances and future directions. Int. J. Med. Sci., 9 (3), 193–199.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Jaffray D.A., Gospodarowicz M. K. Radiation therapy for cancer // Cancer: Disease Control Priorities. 3rd ed. / eds. by H. Gelband et al. Washington, DC: The International Bank for Reconstruction and Development, 2015. Vol. 3.</mixed-citation><mixed-citation xml:lang="en">Jaffray D.A., Gospodarowicz M. K. Radiation therapy for cancer. In Gelband H. et al. (eds.) (2015). Cancer: Disease Control Priorities. 3rd ed. Washington, DC: The International Bank for Reconstruction and Development, 3.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Liu M., Guo F. Recent updates on cancer immunotherapy // Prec. Clin. Med. 2018. Vol. 1 (2). Р. 65–74.</mixed-citation><mixed-citation xml:lang="en">Liu M., Guo F. (2018). Recent updates on cancer immunotherapy. Prec. Clin. Med., 1 (2), 65–74.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Waldman A.D., Fritz J.M., Lenardo M.J. A guide to cancer immunotherapy: from T cell basic science to clinical practice // Nature Rev. Immunol. 2020. Vol. 20 (11). P. 651–668.</mixed-citation><mixed-citation xml:lang="en">Waldman A.D., Fritz J.M., Lenardo M.J. (2020). A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nature Rev. Immunol., 20 (11), 651–668.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Esfahani K., Roudaia L., Buhlaiga N. et al. A review of cancer immunotherapy: from the past, to the present, to the future // Current Oncol. 2020. Vol. 27 (2). P. S87–S97.</mixed-citation><mixed-citation xml:lang="en">Esfahani K., Roudaia L., Buhlaiga N. et al. (2020). A review of cancer immunotherapy: from the past, to the present, to the future. Current Oncol., 27 (2), S87–S97.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Christofi T., Baritaki S., Falzone L., Libra M., Zaravinos A. Current perspectives in cancer immunotherapy // eCancer. 2019. Vol. 11 (10): 1472.</mixed-citation><mixed-citation xml:lang="en">Christofi T., Baritaki S., Falzone L., Libra M., Zaravinos A. (2019). Current perspectives in cancer immunotherapy. Cancers, 11 (10), 1472.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Alberts B., Johnson A., Lewis J. et al. Molecular Bio logy of the Cell. 4th ed. New York: Garland Science, 2002.</mixed-citation><mixed-citation xml:lang="en">Alberts B., Johnson A., Lewis J. et al. (2002). Molecular Biology of the Cell. 4th ed. New York: Garland Science.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Chakraborty S., Rahman T. The difficulties in cancer treatment // eCancer. 2012. Vol. 6: ed16.</mixed-citation><mixed-citation xml:lang="en">Chakraborty S., Rahman T. (2012). The difficulties in cancer treatment. eCancer. 6, ed16.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
