jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)10.31549/2542-1174-2021-4-97-107jsms-779Research ArticleОБЗОРЫREVIEWКлинические, метаболические и гормональные особенности формирования синдрома нарушения распознавания гипогликемииClinical, metabolic and hormonal features of the formation of impaired hypoglycemia awarenessРеваИ. А.RevaI. А.

Рева Инна Александровна — клинический ординатор кафедры эндокринологии 

630091, г. Новосибирск, Красный пр., 52

Inna A. Reva  — Clinical Resident, Department of Endocrinology

52, Krasny Prospect, Novosibirsk, 630091 

innaalexreva@yandex.ruБондарьИ. А.BondarI. А.

Бондарь Ирина Аркадьевна — д-р мед. наук, профессор, заведующий кафедрой эндокринологии; главный эндокринолог Сибирского федерального округа 

Irina A. Bondar — Dr. Sci. (Med.), Professor, Head, Department of Endocrinology; Chief Endocrinologist, Siberian Federal District 

ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииРоссияNovosibirsk State Medical UniversityRussian Federation2021200120220497107Copyright © Рева И.А., Бондарь И.А., 20222022Рева И.А., Бондарь И.А.Reva I.А., Bondar I.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/779

В обзоре представлены распространенность, патогенетические аспекты развития синдрома нарушения распознавания гипогликемии при сахарном диабете и его влияние на течение основного заболевания. Ключевым аспектом в патогенезе нераспознанных гипогликемий является адаптация головного мозга к низкой концентрации глюкозы в крови, что влечет за собой нарушение гормонального ответа на гипогликемию. Данный процесс представляет собой автономную дисфункцию, ассоциированную с гипогликемией. Отмечена роль нарушения распознавания гипогликемий в развитии сердечно-сосудистых осложнений, когнитивных нарушений и патологии беременности у больных сахарным диабетом.

The review presents the prevalence, pathogenetic aspects of the development of impaired hypoglycemia awareness in diabetes mellitus and its effect on the course of the disease. A key aspect in the pathogenesis of atypical hypoglycemias is the brain adaptation to a low glucose concentration in blood, which entails a disorder of hormonal response to hypoglycemia. This process is an autonomous dysfunction associated with hypoglycemia. It is noted the role of atypical hypoglycemia in the development of cardiovascular complications, cognitive impairments and pregnancy failure in patients with diabetes mellitus.

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The authors declare that there are no conflicts of interest present.