jsmsJournal of Siberian Medical SciencesJournal of Siberian Medical Sciences2542-1174Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)10.31549/2542-1174-2021-4-108-133jsms-780Research ArticleОБЗОРЫREVIEWАберрантная экспрессия и метилирование генов отдельных микроРНК при лимфопролиферативных заболеваниях: обзор литературыAberrant expression and methylation of individual microRNAs genes in lymphoproliferative diseases: a literature reviewВоропаеваЕ. Н.VoropaevaE. N.

Воропаева Елена Николаевна — д-р мед. наук, ст. научный сотрудник лаборатории молекулярно-генетических исследований терапевтических заболеваний

Новосибирск

Elena N. Voropaeva — Dr. Sci. (Med.), Senior Researcher, Laboratory for Molecular Genetic Research of Therapeutic Diseases 

Novosibirsk

БерезинаО. В.BerezinaO. V.

Березина Ольга Валерьевна — канд. мед. наук, врач-гематолог, ассистент кафедры терапии, гематологии и трансфузиологии 

Olga V. Berezina — Cand. Sci. (Med.), Hematologist, Assistant, Department of Therapy, Hematology and Transfusiology 

ЧуркинаМ. И.ChurkinaM. I.

Чуркина Мария Игоревна  — аспирант кафедры терапии, гематологии и трансфузиологии 

630091, г. Новосибирск, Красный пр., 52

Maria I. Churkina — Post-Graduate Student, Department of Therapy, Hematology and Transfusiology 

52, Krasny Prospect, Novosibirsk, 630091 

nats.sagan@yandex.ruПоспеловаТ. И.PospelovaT. I.

Поспелова Татьяна Ивановна — д-р мед. наук, профессор, заведующий кафедрой терапии, гематологии и трансфузиологии  

Tatiana I. Pospelova — Dr. Sci. (Med.), Professor, Head, Department of Therapy, Hematology and Transfusiology 

ЛызловаА. А.LyzlovaA. A.

Лызлова Арина Андреевна — врач-гематолог 

Arina A. Lyzlova — Hematologist 

МаксимовВ. Н.MaksimovV. N.

Максимов Владимир Николаевич — д-р мед. наук, главный научный сотрудник, заведующий лабораторией молекулярно-генетических исследований терапевтических заболеваний  

Новосибирск

Vladimir N. Maksimov — Dr. Sci. (Med.), Chief Researcher, Head, Laboratory for Molecular Genetic Research of Therapeutic Diseases 

Novosibirsk

НИИ терапии и профилактической медицины — филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»РоссияInstitute of Internal and Preventive MedicineRussian FederationФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииРоссияNovosibirsk State Medical UniversityRussian FederationГБУЗ НСО «Государственная Новосибирская областная клиническая больница»РоссияState Novosibirsk Regional Clinical HospitalRussian Federation20212001202204108133Copyright © Воропаева Е.Н., Березина О.В., Чуркина М.И., Поспелова Т.И., Лызлова А.А., Максимов В.Н., 20222022Воропаева Е.Н., Березина О.В., Чуркина М.И., Поспелова Т.И., Лызлова А.А., Максимов В.Н.Voropaeva E.N., Berezina O.V., Churkina M.I., Pospelova T.I., Lyzlova A.A., Maksimov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://jsms.elpub.ru/jour/article/view/780

В последние десятилетия обнаружено, что микроРНК участвуют практически во всех клеточных процессах, в том числе в развитии опухолей.В представленном обзоре рассмотрена молекулярно-генетическая характеристика ряда микроРНК, функционирующих при нормальном кроветворении, нарушение экспрессии которых показано при развитии лимфопролиферативных заболеваний. Приведены последние опубликованные результаты исследований по диагностическому, прогностическому и клиническому значению метилирования генов рассматриваемых микроРНК при злокачественных новообразованиях системы крови.

In recent decades, it has been found that microRNAs are involved in almost all cellular processes, including the development of tumors.In this paper, we consider the molecular genetic characteristics of a number of microRNAs that function in normal hematopoiesis, whose expression is impaired in the development of lymphoproliferative diseases. The last published results of studies on the diagnostic, prognostic and clinical significance of gene methylation considered by microRNAs in malignant neoplasms of the blood system are presented.

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The authors declare that there are no conflicts of interest present.