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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2022-6-2-18-27</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-823</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Значение опережающей реакции вегетативной нервной системы в условиях когнитивной нагрузки у условно здоровых студентов</article-title><trans-title-group xml:lang="en"><trans-title>Autonomic nervous system antedating response signifi cance in the apparently healthy students under conditions of cognitive load</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8482-3319</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арчибасова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Archibasova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арчибасова Елена Алексеевна – канд. мед. наук, доцент кафедры нормальной физиологии и основ безопасности жизнедеятельности</p><p>630091, г. Новосибирск, Красный пр., 52</p></bio><bio xml:lang="en"><p>Elena A. Archibasova – Cand. Sci. (Med.), Associate Professor, Department of Normal Physiology and Fundamentals of Life Safety</p><p>52, Krasny prosp., Novosibirsk, 630091</p></bio><email xlink:type="simple">helen280776@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликов</surname><given-names>В. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikov</surname><given-names>V. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куликов Вячеслав Юрьевич – д-р мед. наук, заслуженный деятель науки РФ, профессор кафедры нормальной физиологии и основ безопасности жизнедеятельности</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Vyacheslav Yu. Kulikov – Dr. Sci. (Med.), Honored Scientist of the Russian Federation, Professor, Department of Normal Physiology and Fundamentals of Life Safety</p><p>Novosibirs</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воевода</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Voevoda</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воевода Михаил Иванович – д-р мед. наук, профессор, академик РАН, директор</p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Mikhail I. Voevoda – Dr. Sci. (Med.), Professor, Academician of the Russian Academy of Sciences, Head</p><p>Novosibirs</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Fundamental and Translational Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2022</year></pub-date><volume>0</volume><issue>2</issue><fpage>18</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Арчибасова Е.А., Куликов В.Ю., Воевода М.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Арчибасова Е.А., Куликов В.Ю., Воевода М.И.</copyright-holder><copyright-holder xml:lang="en">Archibasova E.A., Kulikov V.Y., Voevoda M.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/823">https://jsms.elpub.ru/jour/article/view/823</self-uri><abstract><sec><title>В в е д е н и е</title><p>В в е д е н и е . Опережающие механизмы регуляции позволяют человеку более эффективно адаптироваться к воздействию средовых факторов с формированием оптимальной структуры ответной реакции.</p></sec><sec><title>Ц е л ь</title><p>Ц е л ь . Выявить особенности опережающей реакции вегетативной нервной системы в условиях когнитивной нагрузки у условно здоровых студентов.</p><p>М а т е р и а л ы  и  м е т о д ы . В исследовании участвовали 30 студентов медицинского университета в возрасте 18–19 лет. Участники были разделены на две группы (15 чел. в каждой). В группе 1 в качестве нагрузки применялся тест «семантическая вербальная беглость», в группе 2 – тест Амтхауэра. Кардиоинтервалограммы у обследуемых юношей записывалась в условиях контроля и нагрузки. Оценивались показатели вариабельности сердечного ритма (ВСР) – RRNN, ТР, HF, LF, VLF.</p></sec><sec><title>Р е з у л ь т а т ы</title><p>Р е з у л ь т а т ы . Анализ ВСР в группе 1 выявил, что после нагрузки показатели RRNN, ТР, HF, LF достоверно снижаются, в группе 2 после нагрузки показатели ТР и LF достоверно повышаются относительно контрольных значений. Методом корреляционного анализа выявлены отличия между показателями ВСР на момент подготовки к выполнению когнитивного теста между исследуемыми группами. В группе 1 в отличие от группы 2 отсутствовала корреляционная зависимость между показателями RRNN и HF, TP и LF, HF и LF, LF и VLF. После проведения теста в группе 1 выявлена достоверная положительная корреляция между показателями RRNN и HF. В группе 2 определены корреляционные взаимоотношения между показателями RRNN и LF, взаимодействие между HF и LF увеличилось, корреляция между параметрами LF и VLF отсутствует. Отличия между показателями ВСР на момент подготовки к выполнению когнитивного теста показали, что ожидание предстоящей нагрузки определяет реакцию регуляторных механизмов ВСР на действие нагрузки.</p></sec><sec><title>З а к л ю ч е н и е</title><p>З а к л ю ч е н и е . Различные варианты когнитивных нагрузок способствуют изменению активности отделов вегетативной нервной системы в регуляции ВСР. Характер этих изменений зависит от исходного уровня регуляторных возможностей ВСР, определяющих опережающий вариант реагирования на предъявляемую когнитивную нагрузку. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>I n t r o d u c t i o n</title><p>I n t r o d u c t i o n . Anticipating regulatory mechanisms allow a person to more effectively adapt to the impact of environmental factors with the formation of an optimal response structure.A i m . To reveal the features of the antedating response of the autonomic nervous system under conditions of cognitive load in apparently healthy students.</p><p>M a t e r i a l s  a n d  m e t h o d s . The study involved 30 medical university students aged 18–19 years. The partici- pants were divided into two groups (15 people in each). In group 1, the semantic verbal fl uency test was used as a load, in group 2 – the Intelligence Structure Test (IST) by Amthauer. RR intervals in the examined young men were recorded under control and load conditions. The indicators of heart rate variability (HRV) were assessed – RRNN, TP, HF, LF, VLF.</p></sec><sec><title>R e s u l t s</title><p>R e s u l t s . Analysis of HRV in group 1 revealed that after exercise, RRNN, TP, HF, and LF indicators signifi cantly decreased; in group 2, after exercise, TP and LF indicators signifi cantly increased relative to control values. Using correlation analysis, we revealed diff erences between the HRV indicators at the time of preparation for the cognitive test between the studied groups. In group 1, unlike group 2, there was no correlation between RRNN and HF, TP and LF, HF and LF, LF and VLF. After the test in group 1, a signifi cant positive correlation was found between RRNN and HF. In group 2, the correlation relationships between the RRNN and LF indicators were determined, the interaction between HF and LF increased, there were no correlation between the LF and VLF indicators. Diff erences between the HRV indicators at the time of preparation for the cognitive test showed that the anticipation of the upcoming examination determines the response of the HRV regulatory mechanisms to the action of the load.</p></sec><sec><title>C o n c l u s i o n</title><p>C o n c l u s i o n . Diff erent variants of cognitive loads contribute to changes in the activity of the autonomic nervous system in the regulation of HRV. The nature of these changes depends on the initial level of regulatory capabilities of HRV, which determine the antedating response to the cognitive load. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>опережающая реакция вегетативной нервной системы</kwd><kwd>когнитивная нагрузка</kwd><kwd>вариабельность сердечного ритма</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antedating response of the autonomic nervous system</kwd><kwd>cognitive load</kwd><kwd>heart rate variability</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Анохин П.К. Теория отражения и современная наука о мозге. М.: Знание, 1970. 46 с.</mixed-citation><mixed-citation xml:lang="en">Anokhin P.K. (1970). Refl ection Theory and Modern Brain Science. Мoscow: Znanie. 46 p. 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