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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2022-6-3-7-14</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-842</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Риск суицидального поведения при депрессии в структуре биполярного аффективного расстройства, осложненного зависимостью от растительных каннабиноидов</article-title><trans-title-group xml:lang="en"><trans-title>The risk of suicidal behavior in depression in the structure of bipolar disorder complicated by plant cannabinoid addiction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Климова</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimova</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Климова Ирина Юрьевна – ассистент кафедры психиатрии, наркологии, психотерапии и клинической психологии.</p><p>Новосибирск.</p><p>SPIN-код: 5189-8069</p></bio><bio xml:lang="en"><p>Irina Yu. Klimova – Assistant, Department of Psychiatry, Narcology, Psychotherapy and Clinical Psychology, Novosibirsk State Medical University.</p><p>Novosibirsk.</p><p>SPIN-code: 5189-8069</p></bio><email xlink:type="simple">iri.c2012@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1468-1620</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчинников</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovchinnikov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овчинников   Анатолий   Александрович – доктор медицинских наук, профессор кафедры психиатрии, наркологии, психотерапии и клинической психологии.</p><p>Новосибирск.</p><p>SPIN-код: 2228-5923</p></bio><bio xml:lang="en"><p>Anatoliy A. Ovchinnikov – Dr. Sci. (Med.), Professor, Department of Psychiatry, Narcology, Psychotherapy and Clinical Psychology, Novosibirsk State Medical University.</p><p>Novosibirsk.</p><p>SPIN-code: 2228-5923</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>26</day><month>09</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>7</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Климова И.Ю., Овчинников А.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Климова И.Ю., Овчинников А.А.</copyright-holder><copyright-holder xml:lang="en">Klimova I.Y., Ovchinnikov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/842">https://jsms.elpub.ru/jour/article/view/842</self-uri><abstract><sec><title>В в е д е н и е</title><p>В в е д е н и е .  По данным клинических наблюдений депрессивные состояния в структуре биполярного аффективного расстройства (БАР) наблюдаются у 23.8 % обследованных больных. В большинстве исследований показано, что в сравнении с общей популяцией стандартизированный коэффициент смертности у больных составляет около 30 %; на долю пациентов с БАР приходится 1.4 % от общего числа смертей.</p></sec><sec><title>Ц е л ь</title><p>Ц е л ь .  Оценить степень риска суицидального поведения при депрессии в структуре БАР, осложненного употреблением растительных каннабиноидов.</p><p>М а т е р и а л ы    и    м е т о д ы .  Для данного исследования было отобрано 58 пациентов с диагнозом «биполярное аффективное расстройство, ассоциированное с синдромом зависимости от употребления каннабиноидов» – основная группа (средний возраст 34 ± 4 года). Группу контроля составили 100 чел. с БАР без ассоциированной патологии (средний возраст 32 ± 3 года). Длительность заболевания в обеих группах – от 1 года до 5 лет. В исследовании использовались следующие методы и шкалы: клинический метод – оценка психического статуса, шкала депрессии Бека, шкала тревоги Спилбергера – Ханина, шкала оценки риска суицида (SAD PERSONS Scale).</p></sec><sec><title>Р е з у л ь т а т ы</title><p>Р е з у л ь т а т ы .   Проведенное исследование показало, что риск суицидального поведения при депрессии в структуре БАР, осложненного зависимостью от растительных каннабиноидов, значительно повышается, что подтверждается результатами оценки по психометрическим шкалам (через 6 мес от начала исследования в основной группе высокий риск суицида диагностирован в 8 % случаев, через 12 мес – в 11 %, очень высокий риск – в 4 % случаев). Утяжеление психического состояния подтверждалось частотой и большей продолжительностью госпитализаций в круглосуточный психиатрический стационар: в основной группе средняя продолжительность госпитализации в стационар через 6 мес от начала исследования составила около 5.3 ± 2 мес (67 % (p &lt; 0.005)), через 12 мес от начала исследования – около 5.9 ± 1 мес (72 % (p &lt; 0.005)). При терапии данной категории больных отмечена высокая фармакологическая резистентность (73–86 % (p &lt; 0.05)).</p></sec><sec><title>З а к л ю ч е н и е</title><p>З а к л ю ч е н и е . Употребление  растительных  каннабиноидов  повышает  риск  суицидального  поведения. Депрессия в структуре БАР, ассоциированная с зависимостью от растительных каннабиноидов отличалась фармакорезистентностью к проводимой терапии. Повышение уровня тревоги приводило к компульсивным суицидным попыткам, являющимся ключевым фактором риска завершенного суицида.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>I n t r o d u c t i o n</title><p>I n t r o d u c t i o n .  According to clinical observations, depressive states in the structure of bipolar disorder (BD) are observed in 23.8% of the examined patients. Most studies show that compared with the general population, the standardized mortality rate in patients is about 30%; BD patients account for 1.4% of total deaths.</p></sec><sec><title>A i m</title><p>A i m .  To assess the risk of suicidal behavior in depression in the structure of BD complicated by plant cannabinoid addiction.</p><p>M a t e r i a l s   a n d   m e t h o d s .  For this research, 58 patients with diagnosed BD associated with the syndrome of cannabinoid addiction were selected – the main group (mean age 34 ± 4 years). The control group consisted of 100 individuals with BD without associated pathology (mean age 32 ± 3 years). The duration of the disease in both groups ranged from 1 to 5 years. The following methods and scales were used in the study: clinical method – mental status assessment, the Beck Depression Inventory, the State-Trait Anxiety Inventory, the SAD PERSONS Scale – a scale for suicide risk assessment.</p></sec><sec><title>R e s u l t s</title><p>R e s u l t s .  The study showed that the risk of suicidal behavior in depression in the structure of BD complicated by plant cannabinoid addiction increases significantly, which is confirmed by the results of assessment using psychometric scales (after 6 months since the beginning of the study in the main group, a high risk of suicide was diagnosed in 8% of cases, after 12 months – in 11%, very high risk – in 4% of cases). The deterioration of the mental state was confirmed by the frequency and longer duration of hospitalizations in a psychiatric hospital: in the main group, the average duration of hospitalization in a psychiatric hospital after 6 months since the beginning of the study was about 5.3 ± 2 months (67% (p &lt; 0.005)), after 12 months – about 5.9 ± 1 months (72% (p &lt; 0.005)). In the treatment of this category of patients, high drug resistance was noted (73–86% (p &lt; 0.05)).</p></sec><sec><title>C o n c l u s i o n</title><p>C o n c l u s i o n .  The use of plant cannabinoids increases the risk of suicidal behavior. Depression in the structure of BD associated with plant cannabinoid addiction was characterized by resistance to therapy. An increase in anxiety levels led to compulsive suicide attempts which is a key risk factor for completed suicide.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>риск суицидального поведения</kwd><kwd>биполярное аффективное расстройство</kwd><kwd>каннабиоиды</kwd><kwd>фармакорезистентность</kwd><kwd>абстиненция</kwd><kwd>депрессия</kwd><kwd>тревога</kwd><kwd>аффективные нарушения</kwd><kwd>зависимость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>risk of suicidal behavior</kwd><kwd>bipolar disorder</kwd><kwd>cannabinoids</kwd><kwd>drug resistance</kwd><kwd>abstinence</kwd><kwd>depression</kwd><kwd>anxiety</kwd><kwd>aﬀective disorders</kwd><kwd>addiction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Незнанов Н.Г., Рукавишников Г.В., Касьянов Е.Д., Жиляева Т.В., Мазо Г.Э. 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