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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2022-6-3-42-56</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-845</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Состояние периферической гемоциркуляции и возможности немедикаментозной коррекции микроциркуляторных изменений у пациентов с профессиональными артрозами</article-title><trans-title-group xml:lang="en"><trans-title>Peripheral blood circulation and the possibility of non-drug correction of microcirculatory changes in patients with occupational osteoarthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3446-8018</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кармановская</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karmanovskaya</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кармановская Светлана Александровна – доктор медицинских наук, доцент кафедры госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Svetlana A. Karmanovskaya – Dr. Sci. (Med.), Associate Professor, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0871-7551</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шпагина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shpagina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шпагина Любовь Анатольевна – доктор медицинских, профессор, заведующий кафедрой госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Lyubov A. Shpagina – Dr. Sci. (Med.), Professor, Head, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7093-3071</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дробышев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Drobyshev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дробышев Виктор Анатольевич – доктор медицинских наук, профессор кафедры госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Viktor A. Drobyshev – Dr. Sci. (Med.), Professor, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><email xlink:type="simple">doctorvik@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0724-1539</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котова</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotova</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Котова Ольга Сергеевна – доктор медицинских наук, доцент кафедры госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Olga S. Kotova – Dr. Sci. (Med.), Associate Professor, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3109-9811</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шпагин</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shpagin</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шпагин   Илья   Семенович – доктор медицинских наук, доцент кафедры госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Ilya S. Shpagin – Dr. Sci. (Med.), Associate Professor, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паначева</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Panacheva</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Паначева Людмила Алексеевна – доктор медицинских наук, профессор кафедры госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Lyudmila A. Panacheva – Dr. Sci. (Med.), Professor, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7428-9159</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кузнецова Галина Владимировна – кандидат медицинских наук, доцент кафедры госпитальной терапии и медицинской реабилитации.</p><p>Новосибирск.</p></bio><bio xml:lang="en"><p>Galina V. Kuznetsova – Cand. Sci. (Med.), Associate Professor, Department of Hospital Therapy and Medical Rehabilitation, Novosibirsk State Medical University.</p><p>Novosibirsk.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>42</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кармановская С.А., Шпагина Л.А., Дробышев В.А., Котова О.С., Шпагин И.С., Паначева Л.А., Кузнецова Г.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Кармановская С.А., Шпагина Л.А., Дробышев В.А., Котова О.С., Шпагин И.С., Паначева Л.А., Кузнецова Г.В.</copyright-holder><copyright-holder xml:lang="en">Karmanovskaya S.A., Shpagina L.A., Drobyshev V.A., Kotova O.S., Shpagin I.S., Panacheva L.A., Kuznetsova G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/845">https://jsms.elpub.ru/jour/article/view/845</self-uri><abstract><sec><title>В в е д е н и е</title><p>В в е д е н и е .  Низкоинтенсивная электроимпульсная стимуляция пораженных суставов активирует микроциркуляцию и трофику тканей, выход в сосудистое русло опиоидных нейропептидов, что определяет использование чрескожной электронейростимуляции в качестве эффективного и малозатратного метода реабилитации профессиональных гонартрозов.</p></sec><sec><title>Ц е л ь</title><p>Ц е л ь .   Изучить состояние артерий  нижних конечностей у пациентов с профессиональными гонартрозами (ПГА) и обосновать применение динамической электронейростимуляции (ДЭНС) для коррекции микроциркуляторных нарушений.</p><p>М а т е р и а л ы   и   м е т о д ы .  Обследовано 55 мужчин с ПГА (средний возраст 49.3 ± 3.6 года, средний стаж работы 22.3 ± 3.6 года) – основная группа. Группу контроля составили 20 практически здоровых мужчин, работающих в допустимых условиях труда. Проведены ультразвуковое допплерографическое исследование сосудов нижних конечностей и лазерная допплеровская флоуметрия. Для оценки немедикаментозной коррекции микроциркуляторных изменений пациенты основной группы были рандомизированы в две группы: 1-я (35 чел.) получала стандартный комплекс лечения в комбинации с ДЭНС в течение 14 дней. Пациенты 2-й группы (20 чел.) получали только стандартную терапию.</p></sec><sec><title>Р е з у л ь т а т ы</title><p>Р е з у л ь т а т ы .  При допплерографии в заднеберцовых артериях у пациентов с ПГА было выявлено повышение, относительно контрольных показателей, систоло-диастолического индекса на 11.48 %, индекса резистентности – на 6.9 %, индекса пульсации – на 8.8 %, а также увеличение показателя толщины комплекса интима-медиа в 1.46 раза. У пациентов с ПГА выявлено снижение показателя микроциркуляции, относительно показателей контрольной группы, в 1.3 раза, амплитуды вазомоторных (Аv) и пульсовых (Ап) колебаний – в 1.6 и 2.4 раза соответственно. При проведении дыхательной и окклюзионной проб у пациентов с ПГА выявлено, в сравнении с аналогичными показателями контрольной группы, увеличение показателя резерва капиллярного кровотока (РКК) в 1.2 и 1.3 раза соответственно, показателя «биологического нуля» – в 1.4 раза и уменьшение времени полувосстановления кровотока в 1.2 раза. У пациентов после лечения с применением ДЭНС показатель микроциркуляции увеличился в 1.2 раза от исходных значений, показатели амплитуды медленных Аv и Ап колебаний выросли в 1.2 и 1.9 раза соответственно, РКК в дыхательной пробе снизился в 1.3 раза, а в окклюзионной увеличился в 1.16 раза, чего не отмечалось в группе стандартной терапии.</p></sec><sec><title>З а к л ю ч е н и е</title><p>З а к л ю ч е н и е .  У пациентов с ПГА выявляется значимое ремоделирование подколенных и заднеберцовых артерий, нарушение процессов микроциркуляции при одновременном снижении реактивности сосудистой стенки и застойных явлениях в венозных микрососудах. Оптимизация комплексного лечения гонартрозов низкоинтенсивной электроимпульсной стимуляцией оказывает положительное влияние на состояние микроциркуляции, способствуя увеличению перфузии тканей и уменьшению застойных явлений в венулах.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>I n t r o d u c t i o n</title><p>I n t r o d u c t i o n .  Low-intensity pulsed electric stimulation of the aﬀected joints activates microcirculation and trophism, release of opioid neuropeptides into the vascular bed, which determines the use of transcutaneous electric nerve stimulation as an eﬀective and low-cost method for the rehabilitation of occupational knee osteoarthritis.</p></sec><sec><title>A i m</title><p>A i m .  To study the state of the arteries of the lower extremities in patients with occupational knee osteoarthritis (OKO) and substantiate the use of dynamic electric nerve stimulation (DENS) for the correction of microcirculatory disorders.</p><p>M a t e r i a l s   a n d   m e t h o d s .  The study included 55 men with occupational OKO (mean age 49.3 ± 3.6 years, mean work experience 22.3 ± 3.6 years) – the main group. The control group consisted of 20 apparently healthy men working in allowable job conditions. Doppler ultrasound of vessels of the lower extremities and laser Doppler flowmetry were performed. To assess the non-drug correction of microcirculatory changes, the patients of the main group were randomized into two groups: the 1st group (35 individuals) received a conventional treatment in combination with DENS for 14 days. Patients of the 2nd group (20 individuals) received only conventional therapy.</p></sec><sec><title>R e s u l t s</title><p>R e s u l t s .  Doppler ultrasound for the posterior tibial arteries in patients with OKO showed an increase in the systolic-diastolic ratio by 11.48% from the baseline values, the resistivity index – by 6.9%, the pulsatility index – by 8.8%, and an increase in intima-media thickness by 1.46 times as well. In patients with OKO, a decrease in the microcirculation indicator by 1.3 times was revealed, relative to the indicators of the control group; the amplitude of vasomotor (Av) and pulsatile (Ap) oscillations – by 1.6 and 2.4 times, respectively. When performing the breath-holding and occlusion tests in patients with OKO and the control group, an increase in capillary blood flow reserve (CBFR) by 1.2 and 1.3 times, respectively, was revealed; as well as the biological zero values – by 1.4 times and a decrease in the half time of blood flow recovery – by 1.2 times. In patients after treatment with DENS, the microcirculation indicator increased by 1.2 times compared to the baseline values, the amplitudes of slow Av and Ap oscillations increased by 1.2 and 1.9 times, respectively, BFR in the breath-holding test decreased by 1.3 times, and in the occlusion test increased by 1.16 times, which was not observed in the 2nd group.</p></sec><sec><title>C o n c l u s i o n</title><p>C o n c l u s i o n .  In patients with OKO, the significant remodeling of the popliteal and posterior tibial arteries, impaired microcirculation processes with a simultaneous decrease in the vascular reactivity and congestion in venous microvessels are revealed. Optimization of the comprehensive treatment of knee osteoarthritis by low-intensity pulsed electric stimulation has a positive eﬀect on microcirculation, contributing to an increase in tissue perfusion and a decrease in venular congestion.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>профессиональный гонартроз</kwd><kwd>линейная скорость кровотока</kwd><kwd>ремоделирование сосудов</kwd><kwd>динамическая</kwd></kwd-group><kwd-group xml:lang="en"><kwd>occupational knee osteoarthritis</kwd><kwd>blood flow velocity</kwd><kwd>vascular remodeling</kwd><kwd>dynamic electric nerve stimulation</kwd><kwd>indicator of microcirculation</kwd><kwd>pulsatile oscillations</kwd><kwd>amplitude of vasomotor oscillations</kwd><kwd>capillary blood flow reserve</kwd><kwd>posterior tibial arteries</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Азовскова Т.А., Васюков П.А., Будаш Д.С. 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