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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">jsms</journal-id><journal-title-group><journal-title xml:lang="ru">Journal of Siberian Medical Sciences</journal-title><trans-title-group xml:lang="en"><trans-title>Journal of Siberian Medical Sciences</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2542-1174</issn><publisher><publisher-name>Federal state budgetary educational institution of higher education "Novosibirsk state medical university" of  Ministry of Health of the Russian Federation (FSBEI HE NSMU MOH Russia)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31549/2542-1174-2023-7-1-7-17</article-id><article-id custom-type="elpub" pub-id-type="custom">jsms-880</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Дерматологические проявления, ассоциированные с новой коронавирусной инфекцией в остром и постостром периоде COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Dermatological manifestations associated with a novel coronavirus infection in the acute and post-acute period of COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5961-6980</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Немчанинова</surname><given-names>О. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Nemchaninova</surname><given-names>O. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Немчанинова Ольга Борисовна – д-р мед. наук, профессор, заведующий кафедрой дерматовенерологии и косметологии</p><p>630091, г. Новосибирск, Красный просп., 52</p></bio><bio xml:lang="en"><p>Olga B. Nemchaninova – Dr. Sci. (Med.), Professor, Head, Department of Dermatovenereology and Cosmetology</p><p>52, Krasny prosp., Novosibirsk, 630091</p></bio><email xlink:type="simple">obnemchaninova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2124-340X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симонова</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonova</surname><given-names>Е. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симонова Елена Павловна – канд. мед. наук, младший научный сотрудник </p><p>Новосибирск</p></bio><bio xml:lang="en"><p>Elena P. Simonova – Cand. Sci. (Med.), Junior Researcher</p><p>Novosibirsk</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ терапии и профилактической медицины – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики» СО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Therapy and Preventive Medicine, Branch of the Federal Research Center Institute of Cytology and Genetics</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>03</day><month>04</month><year>2023</year></pub-date><volume>0</volume><issue>1</issue><fpage>7</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Немчанинова О.Б., Симонова Е.П., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Немчанинова О.Б., Симонова Е.П.</copyright-holder><copyright-holder xml:lang="en">Nemchaninova O.B., Simonova Е.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://jsms.elpub.ru/jour/article/view/880">https://jsms.elpub.ru/jour/article/view/880</self-uri><abstract><sec><title>Введение</title><p>Введение. Дерматологические проявления новой коронавирусной инфекции, вызванной вирусом SARS-CoV-2, отмечаются в разные периоды заболевания и иногда могут быть единственным проявлением COVID-19. Несмотря на то, что в настоящее время суточный прирост новых заболевших коронавирусной инфекцией в Российской Федерации небольшой, вопросы своевременной диагностики, лечения и профилактики COVID-19 сохраняют свою актуальность, а опыт, приобретенный за время пандемии, имеет неоценимое практическое значение.</p></sec><sec><title>Цель</title><p>Цель. Оценка дерматологических проявлений, ассоциированных с новой коронавирусной инфекцией, вызванной SARS-CоV-2, в острый период COVID-19 и в постковидный период.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено когортное несравнительное описательное исследование 120 чел. в возрасте 48–72 года (44 мужчины, 76 женщин), перенесших COVID-19 не ранее чем 12 нед назад.</p></sec><sec><title>Результаты</title><p>Результаты. Изменения кожи и ее придатков отмечались у 72 (60 %) пациентов. У 7 (9.7 %) чел. дерматологические симптомы появились в острый период COVID-19 и были представлены крапивницей, перниоподобными изменениями кожи стоп, отечной эритемой лица и груди, зудом и гиперестезией кожи. В двух случаях высыпания на коже предшествовали появлению респираторных признаков коронавирусной инфекции. Дерматологические проявления постковидного синдрома имели место у 94.4 % больных, из них в 60.3 % случаев диагностирована диффузная алопеция, в 48.5 % – ксероз кожи с зудом и/или парестезией, в 23.5 % – онихопатии, в 14.7 % – впервые возникшие дерматозы, в 38.2 % случаев – сочетание нескольких дерматологических патологий.</p></sec><sec><title>Заключение</title><p>Заключение. Среди поражений кожи, ассоциированных с COVID-19, можно выделить симптомы, типичные для острого периода заболевания, и признаки, характерные для постковидного синдрома. Манифестация дерматологических симптомов в острый период COVID-19 может служить индикатором инфекции, способствуя ее своевременной диагностике. Знания о дерматологических проявлениях постковидного синдрома позволят правильно провести диагностический поиск и назначить адекватное лечение.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Dermatological manifestations of a novel coronavirus infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are observed in the different periods of the disease, and can sometimes be the only manifestation of coronavirus disease 2019 (COVID-19). Despite the fact that at present the daily increase in new cases of coronavirus infection in the Russian Federation is small, the issues of timely diagnosis, treatment and prevention of COVID-19 remain relevant, and the experience gained during the pandemic is of invaluable practical importance.</p></sec><sec><title>Aim</title><p>Aim. Evaluation of dermatological manifestations associated with a novel coronavirus infection caused by SARS-CoV-2 in the acute period of COVID-19 and post-acute one.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A cohort non-comparative descriptive study of 120 people aged 48–72 years (44 men, 76 women), who had COVID-19 no earlier than 12 weeks ago, was carried out.</p></sec><sec><title>Results</title><p>Results. Changes in the skin and its appendages were observed in 72 (60%) patients. In 7 (9.7%) people, dermatological symptoms appeared during the acute period of COVID-19 and were represented by urticaria, pernio-like skin lesions of the feet, edematous erythema of the face and chest, itching and hyperesthesia of the skin. In two cases, skin rashes preceded the onset of respiratory signs of coronavirus infection. Dermatological manifestations of post-COVID syndrome occurred in 94.4% of patients, of which diff use alopecia was diagnosed in 60.3% of cases, skin xerosis with itching and/or paresthesia in 48.5%, onychopathy in 23.5%, new-onset dermatoses in 14.7%, and in 38.2% of cases – a combination of several dermatological disorders.</p></sec><sec><title>Conclusion</title><p>Conclusion. Among the skin lesions associated with COVID-19, we can identify symptoms typical of the acute period of the disease and signs characteristic of post-COVID syndrome. The dermatological manifestation during the acute period of COVID-19 can serve as an indicator of infection, contributing to its timely diagnosis. Knowledge of the dermatological manifestations of post-COVID syndrome will allow us to correctly conduct a diagnostic search and prescribe adequate treatment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>вирус SARS-CoV-2</kwd><kwd>дерматологические проявления</kwd><kwd>постковидный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>dermatological manifestations</kwd><kwd>post-COVID syndrome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Статья подготовлена по результатам выполнения бюджетной темы по государственному заданию № 122031700094-5 «Эпидемиологический мониторинг состояния здоровья населения и изучение молекулярно-генетических и молекулярно-биологических механизмов развития распространенных терапевтических заболеваний в Сибири для совершенствования подходов к их диагностике, профилактике и лечению».</funding-statement><funding-statement xml:lang="en">The article was prepared based on the results of the implementation of the budget topic under state assignment No. 122031700094-5 “Epidemiological monitoring of population health and the study of molecular genetic and molecular biological mechanisms for the development of common diseases in Siberia to improve approaches to their diagnosis, prevention and treatment.”</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хрянин А.А., Стуров В.Г., Надеев А.П., Бочарова В.К. 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