Lipid metabolism during long-term exposure to heavy metals in experimental atherosclerosis
https://doi.org/10.31549/2542-1174-2024-8-1-100-112
Abstract
I n t r o d u c t i o n . Recent literature shows that exposure to heavy metals is an important and underestimated risk factor related to the development of atherosclerosis and its consequences.
A i m . To study the effect of chronic intoxication with different heavy metal salts (cadmium sulfate, nickel nitrate, and cobalt nitrate) on lipid metabolism in experimental atherosclerosis.
M a t e r i a l s a n d m e t h o d s . The experiments were conducted on 110 outbred male albino rats. Atherosclerosis was modeled according to I.V. Savitsky. After modeling atherosclerosis, the animals were chronically exposed to heavy metal salts (cadmium sulfate – 1 mg/kg, nickel nitrate – 2 mg/ kg and cobalt nitrate – 2 mg/kg) via drinking water for 60 days in four experimental series. The comparison group consisted of intact animals. To assess lipid metabolism, total cholesterol (TCH), triglycerides (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL) and the values of the atherogenic coefficient (AC) were determined.
R e s u l t s . After intoxication with various heavy metals of rats with modeled atherosclerosis, a marked aggravation of lipid metabolism disturbances – a significant increase in the level of TCH, TG, LDL and AC with a simultaneous decrease in the level of HDL in the blood serum is revealed. The maximal changes in the parameters of lipid metabolism are observed by the 60th day after intoxication in experimental atherosclerosis.
C o n c l u s i o n . Long-term exposure to heavy metals (cadmium sulfate, nickel nitrate and cobalt nitrate) exacerbates lipid metabolism disorders occurring in experimental atherosclerosis. According to the severity of pathological changes, the following are in descending order: cadmium sulfate → nickel nitrate → cobalt nitrate. Despite the fact that cobalt is one of the essential microelements, long-term exposure to it also leads to an aggravation of lipid metabolism disorders in experimental atherosclerosis.
About the Author
R. I. Ibragimov
Scientific Research Center, Azerbaijan Medical University
Azerbaijan
Azerbaijan
Rashad I. Ibragimov – Cand. Sci. (Pharmaceut.), Senior Researcher, Department of Pharmacology
14, Anver Gasymzade str., Baku, AZ 1022
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For citations:
Ibragimov R.I. Lipid metabolism during long-term exposure to heavy metals in experimental atherosclerosis. Journal of Siberian Medical Sciences. 2024;(1):101-112. (In Russ.) https://doi.org/10.31549/2542-1174-2024-8-1-100-112
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