ASSOCIATION OF POLYMORPHIC GENETIC MARKERS WITH VARIOUS OPTIONS OF ISCHEMIC STROKE
Abstract
After genotyping (PCR) frequencies of alleles and genotypes of 26 SNP-markers at patients wth atherothrombotic and lacunar options of ischemic stroke and at healthy patients are studied. Various, pathogenetically reasonable associations of genetic polymorphism with cerebrovascular accident are revealed. So AGT-704C, SELP-1087A, SELE-128Pro, ApoC3-3238G alleles with risk of development of a disease from 1,52 [1,12; 2,07] to 2,87 [1,89-4,37] to showed for atherothrombotic option predisposition. And AGT-521T, SELE-128Pro, NOS3-786T, NOS1-84A, END-9272T of allele, with probability of disease progress from 1,11 [0,75-1,64] to 2,92 [1,96-4,34] times showed association for lacunar stroke.
About the Author
N. N. Strambovskaya
SBEI HPE «Chita state medical academy» of Ministry of Health
Russian Federation
Russian Federation
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Review
For citations:
Strambovskaya N.N. ASSOCIATION OF POLYMORPHIC GENETIC MARKERS WITH VARIOUS OPTIONS OF ISCHEMIC STROKE. Journal of Siberian Medical Sciences. 2015;(1):12.
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