STUDYING THE PARAMETERS OF ENTERAL TRANSPORT OF MODIFIED HYALURONIDASUM FORMS
Abstract
The esearch objective was studying of parameters of enteral transport of the modified and native Hyaluronidasum from a lumen of a jejunum at rats in experiment. The following experimental models were used: medicine incubation in an intestine (in situ) and a chamber of Ussinga. The assessment of dynamics of the medicine maintenance in a vascular channel, possibility of penetration into a lymphatic channel and rate of absorption was carried out. On both models it was shown that modification of GEBN with poloxamer raises enteral transport of enzyme, frames possibility of obtaining therapeutically significant concentration of a preparation in a blood and in a liver.
About the Authors
M. A. Shilova
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
O. R. Grek
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
P. G. Madonov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
K. I. Ershov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
S. V. Mishenina
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
M. E. Fil
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
M. V. Ramzin
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
References
1. Иоанниди Е. А. Лечение хронических гепатитов: учебно-методическое пособие / Е. А. Ионниди, И. В. Макарова, Е. А. Беликова. - Волгоград : Изд-во Волгоградского гос. аграрного ун-та, 2012. - 48 с.
2. Исследование пути всасывания флуоресцеина из тощей кишки крыс Wistar в систему «кровь-лимфа» / К. И. Ершов [и др.] // Вестн. НГУ. Серия: Биология, клиническая медицина. - 2012. - Т. 10, вып. 4. - С. 41-46.
3. Электронно-лучевая модификация препаратов белковой природы для улучшения их фармакологических свойств [Электронный ресурс] / П. Г. Мадонов [и др.] // Медицина и образование в Сибири : сетевое научное издание. - 2013. - № 4. - Режим доступа : (http://ngmu.ru/cozo/mos/article/text_full.php?id=1115). - Дата обращения : 20.05.2015.
4. Шилова М. А. Исследование биодоступности полимеросом полоксамер - ГЭБНА из тощей кишки крыс / М. А. Шилова, К. И. Ершов, О. Р. Грек // Сб. материалов межрегион. науч.-практ. конф. «Фармация XXI века : актуальные проблемы и перспективы». - Кемерово, 2014. - С. 164-166.
5. Kabanov A. V. Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery / A. V. Kabanov, E. V. Batrakova, V. Y. Alakhov // Journal of Controlled Release. - 2002. - Vol. 82. - Р. 189-212.
6. Emerging trends in oral delivery of peptide and protein drugs / R. I. Mahato [et al.] // Therapeutic Drug Carrier Systems. - 2003. - Vol. 20 (2&3). - P. 153-214.
7. Nanoparticles : pharmacological and toxicological significance / C. Medina [et al.] // Br. J. Pharmacol. - 2007. - Vol. 50. - Р. 552-558.
Review
For citations:
Shilova M.A., Grek O.R., Madonov P.G., Ershov K.I., Mishenina S.V., Fil M.E., Ramzin M.V. STUDYING THE PARAMETERS OF ENTERAL TRANSPORT OF MODIFIED HYALURONIDASUM FORMS. Journal of Siberian Medical Sciences. 2015;(3):80.
Views:
122
Email this article 