STRUCTURAL CHANGES OF SECRETORY APPARATUS OF SUBMANDIBULAR SIALADEN AT EXPERIMENTAL CARCINOGENESIS AND CHEMOTHERAPIES
Abstract
The influence of melatonin, Cyclophosphanum and their combination on features of structure of epithelium adenomeres: myxocytes and serous cells of submandibular sialaden at rats after subinoculations by Walker 256 carcinosarcoma were studied. Suspension of Walker 256 carcinosarcoma cells were implanted into a femur muscle of Vistar rats in volume of 1 × 106 cells. The analysis of received results testified that acinar cells of submandibular sialaden are steady against influence of the paraneoplastic endogenic intoxication which is formed with malignant tumoral growth. Besides, melatonin introduction as monoagent and in combination with Cyclophosphanum, at tumoral growth stimulated intensifying of biosynthetic epithelium function of adenomeres gland of myxocytes and serous cells.
About the Authors
A. O. Kulishenko
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. S. Vinogradov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
E. V. Ovsyanko
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. V. Efremov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
E. N. Samsonova
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
Y. U. Ovsyanko
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
I. P. Zhurakovsky
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. N. Mashak
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
T. A. Litvinova
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
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Review
For citations:
Kulishenko A.O., Vinogradov A.S., Ovsyanko E.V., Efremov A.V., Samsonova E.N., Ovsyanko Y.U., Zhurakovsky I.P., Mashak A.N., Litvinova T.A. STRUCTURAL CHANGES OF SECRETORY APPARATUS OF SUBMANDIBULAR SIALADEN AT EXPERIMENTAL CARCINOGENESIS AND CHEMOTHERAPIES. Journal of Siberian Medical Sciences. 2015;(3):94.
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