STRUCTURAL CHANGES OF SECRETORY APPARATUS OF SUBMANDIBULAR SIALADEN AT EXPERIMENTAL CARCINOGENESIS AND CHEMOTHERAPIES
Abstract
The influence of melatonin, Cyclophosphanum and their combination on features of structure of epithelium adenomeres: myxocytes and serous cells of submandibular sialaden at rats after subinoculations by Walker 256 carcinosarcoma were studied. Suspension of Walker 256 carcinosarcoma cells were implanted into a femur muscle of Vistar rats in volume of 1 × 106 cells. The analysis of received results testified that acinar cells of submandibular sialaden are steady against influence of the paraneoplastic endogenic intoxication which is formed with malignant tumoral growth. Besides, melatonin introduction as monoagent and in combination with Cyclophosphanum, at tumoral growth stimulated intensifying of biosynthetic epithelium function of adenomeres gland of myxocytes and serous cells.
About the Authors
A. O. Kulishenko
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. S. Vinogradov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
E. V. Ovsyanko
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. V. Efremov
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
E. N. Samsonova
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
Y. U. Ovsyanko
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
I. P. Zhurakovsky
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
A. N. Mashak
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
T. A. Litvinova
SBEI HPE «Novosibirsk State Medical University of Ministry of Health»
Russian Federation
Russian Federation
References
1. Machado A. P. Adipose tissue in Walker 256 tumour-induced cachexia : possible association between decreased leptin concentration and mononuclear cell infiltration / A. P. Machado, L. F. Costa Rosa, M. C. Seelaender // Cell. Tissue Res. - 2004. - Vol. 318, N 3. - P. 503-514.
2. Honnort J. Paraneoplastic neurological syndromes / J. Honnort, J. C. Antoine // Orphanet. J. Rare Dis. - 2007. - N 4. - P. 2-22.
3. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer / T. Browder [et al.] // Cancer Res. - 2000. - Vol. 60. - P. 1878-1886.
4. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity / G. Klement [et al.] // J. Clin. Invest. - 2000. - Vol. 105. - P. 15-24.
5. Иммуногистохимичкский анализ программируемой гибели клеток карциносаркомы Walker 256 при воздействии цитостатическими препаратами / Е. В. Овсянко [и др.] // Бюл. эксперим. биологии и медицины. - 2009.- Т. 149, № 10. - С. 455-460.
6. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status / P. Lissoni [et al.] // Eur. J. Cancer. - 1999. - Vol. 35. - Р. 1688-1692.
7. Экспрессия фактора роста эндотелия сосудов (VEGF-A) в нижнечелюстной слюнной железе крыс в условиях паранеопластического процесса и химиотерапии циклофосфаном и мелатонином / Е. В. Овсянко [и др.] // Бюл. эксперим. Биологии и медицины. - 2014. - Т. 158, № 11. - С. 627-631.
8. Role of melatonin in upper gastrointestinal tract / S. J. Konturek [et al.] // J. Physiol. Pharmacol. - 2007. - Vol. 6. - Р. 23-52.
9. Kennaway D. J. Circadian rhythm of free melatonin in human plasma / D. J. Kennaway, А. Voultsios // The Journal of clinical endocrinology and metabolism. - 1998. - Vol. 83. - Р. 1013-1015.
10. Expression of bone matrix proteins, osteonectin and osteopontin in salivary pleomorphic adenomas ? K. Kusafuka [et al.] // Pathol. Res. Pract. - 1999. - Vol. 195. - Р. 11.
11. Слюнные железы (биохимия, физиология, клинические аспекты) / Л. М. Тарасенко [и др.]. - Томск, 2002. - 124 с.
12. Aure M. H. Salivary Gland Homeostasis Is Maintained through Acinar Cell Self-Duplication / M. H. Aure, S. F. Konieszny, C. E. Ovitt // Dev. Cell. - 2015. - Vol. 2. - Р. 231-237.
13. Mahay S. Streptozotocin-induced type 1 diabetes mellitus alters the morphology, secretory function and acyl lipid contents in the isolated rat parotid salivary gland / S. Mahay [et al.] // Mol. Cell. Biochem. - 2004. - Vol. 261. - Р. 175-181.
14. Динамика опухолевого роста у крыс линии Brattleboro и Wag при введении разных доз карцино-саркомы Walker 256 / И. И. Хегай [и др.] // Бюл. эксперим. биологии и медицины. - 2008. - Т. 145, № 1. - С. 88-90.
Review
For citations:
Kulishenko A.O., Vinogradov A.S., Ovsyanko E.V., Efremov A.V., Samsonova E.N., Ovsyanko Y.U., Zhurakovsky I.P., Mashak A.N., Litvinova T.A. STRUCTURAL CHANGES OF SECRETORY APPARATUS OF SUBMANDIBULAR SIALADEN AT EXPERIMENTAL CARCINOGENESIS AND CHEMOTHERAPIES. Journal of Siberian Medical Sciences. 2015;(3):94.
Views:
138
Email this article 