MORPHOLOGICAL ASSESSMENT OF ULTRASTRUCTURAL CHANGES OF ENDOTHELIOCYTES AT MECHANICAL CARDIAC ABNORMALITY AT EXPERIMENT

Abstract

An experimental modeling of cardiac bruise on the approved model - Vistar white male rats was carried out for the purpose of identification of ultrastructural changes of endotheliocytes of vascular capillaries of myocardium at mechanical cardiac abnormality of different severity. Transmission electron and microscopical research of slices of cardiac ventricles of animals with subsequent statistical processing of the received results was performed. A series of characteristic changes of organellas of endotheliocytes is registered. In particular, experiment allowed revealing at cardiac injury the augmentation of volume densities of mitochondrions, micropinocytic vesicles and depression of volume densities of ribosomes. Thus expression of ultrastructural changes of endotheliocytes depended on severity of cardiac injury.