PROTHROMBOTIC DISTRIBUTION POLYMORPHIC OPTIONS OF GENES AT CHILDREN WITH ISCHEMIC STROKE

Abstract

Research objective : to establish distribution the prothrombotic polymorphic options of genes at children with an ischemic stroke. Materials and methods . Samples of DNA at 25 children with the diagnosis of ischemic stroke at the age of 2-17 years were the material for studying of distribution of polymorphic the options of prothrombotic genes. The method of polymerase chain reaction in real time (Real-Time of PCR) with usage of the competing TaqMan probes was the cornerstone of the analysis. Results . It was revealed that the heterozygotic polymorphic option (-675) 4G/5G of a gene of PAI-1 and a heterozygotic polymorphism of 677 ST of a gene of MTHFR with a larger frequency were defined at patients on acute disturbance of a cerebral circulation. A combination of three and more polymorphic options the prothrombotic of genes were more often revealed in group of sick children. High level of concentration of a homocysteine in blood serum at patients with an ischemic stroke is registered. Conclusions . Research of the prothrombotic of polymorphisms at children and well-timed phenotypic correction of their functional realization will allow to reduce significantly number of patients who have had thrombotic vascular events.