Preview

Journal of Siberian Medical Sciences

Advanced search

SIMULTANEOUS TRANSPLANTATION OF PANCREAS AND KIDNEY AT DIABETIC NEPHROPATHY

Abstract

Simultaneous transplantation of pancreas and kidney is the golden standard of treatment of patients with terminal diabetic nephropathy. Indicators of glucose in blood of recipients reach norm in the first days after transplantation. Practically all patients register improvement of life quality concerning exercise stresses. Nowadays more than 25 000 similar interventions are successfully performed in the world. The standardized surgical equipment with abduction of pancreatic fluid in small bowel through fragment of duodenum graft provides the best short-term postoperative and long-term results. Introduction of new protocols of immunosuppression reduced the frequency of acute graft rejection up to 10%. Numerous successful performance of retransplantation is possible at emergence further irreversible damages of graft, in particular a donor pancreas.

About the Authors

E. Matevossian
The university hospital Klinikum rechts der Isar, Surgery and Transplantation Department, Technical university of Munich
Russian Federation


E. A. Anastasieva
SBEI HPE «Novosibirsk State Medical University» of Ministry of Health
Russian Federation


G. S. Luppa
SBEI HPE «Novosibirsk State Medical University» of Ministry of Health
Russian Federation


D. V. Pavlenko
SBEI HPE «Novosibirsk State Medical University» of Ministry of Health
Russian Federation


I. Snopok
St. Lukas Clinic, Surgery Department, Solingen (Solingen, Germany)
Russian Federation


References

1. Toledo-Pereyra L. H. Richard Carlton Lillehei : transplant and shock surgical pioneer / L. H. Toledo-Pereyra, D. E. Sutherland // J. Invest. Surg. - 2011. - N 24 (2). - P. 49-52.

2. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification // Am. J. Kidney Dis. - 2002. - N 39 (1). - P. 1-266.

3. In patients with Type I Diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria / B. A. Perkins [et al.] // Kidney Int. - 2010. - N 77 (1). - P. 57-64.

4. Shyr Y. M. Pancreas transplantation / Y. M. Shyr // J. Chin. Med. Assoc. - 2009. - N 72. - P. 4-9.

5. Present status of pancreas transplantation / N. Yoshimura [et al.] // Nippon. Rinsho. - 2010. - N 68 (9). - P. 197-201.

6. Kaufman D. B. Simultaneous pancreas-kidney transplants are appropriate in insulin-treated candidates with uraemia regardless of diabetes type / D. B. Kaufman, D. E. Sutherland // Clin. J. Am. Soc. Nephrol. - 2011. - N 65. - P. 957-959.

7. Kimmelstiel P. Benign and malignant hypertension and nephrosclerosis. A clinical and pathological study / Р. Kimmelstiel, C. Wilson // Am. J. Pathol. - 1936. - N 12. - P. 45-48.

8. Pathologic classification of diabetic nephropathy / T. W. Tarvaet [et al.] // J. Am. Soc. Nephrol. - 2010. - N 21 (4). - P. 556-563.

9. Navarro-González J. F. The role of inflammatory cytokines in diabetic nephropathy / J. F. Navarro-González, C. Mora-Fernández // J. Am. Soc. Nephrol. - 2008. - N 19. - P. 433-442.

10. Microsurgical technique of simultaneous pancreas/kidney transplantation in the ra : clinical experience and review of the literature / E. Matevossian [et al.] // Eur. Surg. Res. - 2009. - N 43 (2). - P. 245-251.


Review

For citations:


Matevossian E., Anastasieva E.A., Luppa G.S., Pavlenko D.V., Snopok I. SIMULTANEOUS TRANSPLANTATION OF PANCREAS AND KIDNEY AT DIABETIC NEPHROPATHY. Journal of Siberian Medical Sciences. 2015;(1):41.

Views: 163


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2542-1174 (Print)