Pathogenetic mechanisms of perinatal damage of the central nervous system in case of prenatal encephalitis at the fetuses
Аннотация
We studied the paraventricular zone of thalamic area of a brain of 47 fetuses with signs of prenatal encephalitis in case of the term of a gestation of 26-27 weeks in comparison with 10 healthy fetuses in case of the same term. We showed that pathomorphologic changes in brain of human fetuses in case cellularity of prenatal encephalitis are characterized by a productive and necrotic inflammation. Reduction of cellularity of paraventricular zone, increase in amount of neurons and glial cells in thalamic area, and also the cells he expressing glial fibrous protein, the increased proliferative activity of cells of paraventricular zone indicated the accelerated maturation of its cells in case of prenatal encephalitis. Reduction of number of vessels in paraventricular zone was caused by decrease in expression of vascular endothelial factor of growth and transforming growth factor in cells.
Об авторах
O. Perova
Novosibirsk State Medical University
Россия
Россия
A. Nadeev
Novosibirsk State Medical University
Россия
Россия
M. Travin
Novosibirsk State Medical University
Россия
Россия
Список литературы
1. Belvindrah R., Lazarini F., Lledo P. M. (2009). Postnatal neurogenesis: from neuroblast migration to neuronal integration. Review of Neurosciences, 20(5-6), 331-346.
2. Braun A., Hu F., Xu H. (2007). Paucity of pericytes in germinal matrix vasculature of premature infants. Journal of Neuroscience, 27, 12012-12024.
3. Stratman A.N., Davis C.E. (2012). Endothelial cellpericyte interactions stimulate basement membrane matrix assembly: influence on vascular tube remodeling, maturation, and stabilization. Microscopy and Microanalysis, 18(1), 68-80.
4. Ballabh P. (2010). Intraventricular hemorrhage in premature infants: mechanism of disease. Pediatric Research, 67(1), 1-8.
5. Ballabh P. (2014). Pathogenesis and prevention of intraventricular hemorrhage. Clinics in Perinatology, 41(1), 47-67.
6. Zhang Y.W., Chen Y.H. (2008). Effects of hypoxiaischemia on different neural cells in subventricular zone of human fetus. Zhonghua Er Ke Za Zhi. Chinese Journal of Pediatrics, 46(9), 644-647.
7. Malik S., Vinukonda G., Vose L. R., Diamond D., Bhimavarapu B.B., Hu. F. et al. (2013). Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. Journal of Neuroscience, 9, 33(2), 411-423.
8. Bozoyan L., Khlghatyan J., Saghatelyan A. (2012). Astrocytes control the development of the migrationpromoting vasculature scaffold in the postnatal brain via VEGF signaling. Journal of Neuroscience, 1, 32(5), 1687-1704.
9. Huang X.Q., Zhang X.Y., Wang X.R., Yu S.Y., Fang S.H. et al. (2012). Transforming growth factor β1induced astrocyte migration is mediated in part by activating 5lipoxygenase and cysteinyl leukotriene receptor 1. Journal of Neuroinflammation, 26(9), 145.
10. Dobolyi A., Lovas G., Pál G., Vincze C., Lovac G. (2012). The neuroprotective functions of transforming growth factor Beta proteins. International Journal of Molecular Sciences, 13(7), 8219-8258.
11. Ryu K.Y., Cho G.S., Piao H.Z., Kim W.K. (2012). Role of TGFβ in survival of phagocytizing microglia: autocrine suppression of TNFβ production and oxidative stress. Experimental Neurobiology, 21(4), 151-157.
12. Nadeev A.P., Perova O.V., Zhukova V.A. (2008). Etiological and pathomorphological features of congenital encephalitis. Materials represented at the Russian Research Conference “Important Problems of Pathoanatomical Service”, Chelyabinsk. Р. 274-276.
13. Kozyaev M.A., Nadeev A.P., Perova O.V., Travin M.A. (2011). Perinatal affection of central nervous system in case of congenital encephalitis. Siberian Medical Review, 3, 53-57.
14. Liu X., Bolteus A.J., Balkin D.M. (2006). Glial fibrous sour proteinexpressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia, 54(5), 394-410.
15. Dumitrescu Ozimek L., Okulla T., Sastre M., Semmler A. (2005). Systemic inflammation induces apoptosis with variable vulnerability of different brain regions. Journal of Chemical Neuroanatomy, 30(2-3), 144-157.
Рецензия
Для цитирования:
, , . Journal of Siberian Medical Sciences. 2017;(1):32-36.
For citation:
Perova O.V., Nadeev A.P., Travin M.A. Pathogenetic mechanisms of perinatal damage of the central nervous system in case of prenatal encephalitis at the fetuses. Journal of Siberian Medical Sciences. 2017;(1):32-36.
Просмотров:
120
Послать статью по эл. почте 