Research of the genetic polymorphism of Tolllike receptors in the patients suffering from tuberculosis of respiratory organs
Abstract
Development of tuberculosis is caused by many reasons, but the main is depression of efficiency of functioning of the immune system. The purpose of the work was to identify the frequency of occurrence of alleles and genotypes of TLR2 (Arg753Gln), TLR3 (Phe412Leu), TLR4 (Asp299Gly), TLR6 (Ser249Pro) genes in patients suffering from tuberculosis. The research is performed on the basis of the analysis of clinical findings of 120 patients suffering from tuberculosis and 30 healthy peoples. For studying of a polymorphism of genes of Tolllike receptors (TLRs) we used the method of specific allele polymerase chain reaction with electrophoretic detection. Crucial importance for development of small forms and infiltrative tuberculosis has genetic predisposition in the form of a carriage of mutant genotypes of TLR3 (Phe412Leu) and TLR6 (Ser249Pro) genes. At the same time in pathogenesis of disseminated tuberculosis an important role is played by such factors as an alcoholism, an abuse of narcotics, contact to extractors, etc. The influence of external environment and genetic predisposition in the form of mutant variant of a polymorphism of a gene of TLR6 (Ser249Pro) are characterized by the fibrous and cavernous tuberculosis. The risk ratio of development of tuberculosis in carriers of mutant variants of polymorphism of TLR3 (Phe412Leu) and TLR6 (Ser249Pro) genes is higher in comparison with other variants of polymorphism of the same and other genes.
About the Authors
E. S. Bogodukhova
Chita State Medical Academy
Russian Federation
Russian Federation
E. E. Bayke
Chita State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Bogodukhova E.S., Bayke E.E. Research of the genetic polymorphism of Tolllike receptors in the patients suffering from tuberculosis of respiratory organs. Journal of Siberian Medical Sciences. 2017;(2):27-32.
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