Choice and justification of the method of bacterial purification of hormonal substances at production of medicinal preparations in suspension form for injections in rheumatology
Abstract
The aim of our research is to choose and justify the method of bacterial purification of hormonal substances of active ingredients of betamethasone dipropionate and hydrocortisoni acetas at developing of the most acceptable ways of receiving sterile prepared parenteral suspensions of «Hydrocortisoni Acetas + Lidocaine Hydrochloride» and «Betamethasone» is conducted. We developed two technological methods for obtaining these medicinal preparations which are characterized by identical final quality. They correspond the requirements of the State pharmacopoeia of Ukraine and the European regulatory requirements concerning the choice of a method of bacterial purification of the readymade dosage forms.
About the Author
A. I. Kachaput
Central Laboratory of Pharmaceutical Development Farmak JointStock Company, Kiev, Ukraine
Russian Federation
Russian Federation
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Review
For citations:
Kachaput A.I. Choice and justification of the method of bacterial purification of hormonal substances at production of medicinal preparations in suspension form for injections in rheumatology. Journal of Siberian Medical Sciences. 2017;(2):36-41.
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