Dynamics of abdominal pain syndrome in patients with cholelithiasis throughout the 10-year follow-up period
https://doi.org/10.31549/2542-1174-2018-4-54-66
Abstract
The purpose of the study was to evaluate the dynamics and characteristics of abdominal pain syndrome in patients with cholelithiasis (CL) during a 10-year follow-up period. The work is a fragment of a long-term prospective observation of patients with CL. Patients who participated in the study were divided into 2 groups: the 1st group ( n = 113) of those who had undergone cholecystectomy (CE); 2nd group (comparisons) ( n = 92) included receiving conservative treatment patients who had been diagnosed with CL 10 years before. Patients of both groups were divided according to the initial variant of the CL course: symptomatic and asymptomatic. It was found that in CL patients after CE, the incidence of a biliary pain decreased by 25.7 % ( p < 0.001). In the group with initial symptomatic course cholelithiasis after CE, there was a statistically significant reduction in the biliary pain by 31.1 % compared with patients treated with conservative therapy ( p < 0.001). The incidence of biliary pain increased by 11.9 % ( p < 0.001) in the conservative therapy group, including CL patients with an initially asymptomatic course. The incidence of dyspepsia syndrome increased by 33.9 % ( p = 0.039) in patients after CE, an especially significant reduction was in the initially asymptomatic CL patients.
About the Authors
Y. V. Makarova
Novosibirsk State Medical University
Russian Federation
Russian Federation
N. V. Litvinova
Novosibirsk State Medical University
Russian Federation
Russian Federation
N. B. Voloshinа
Novosibirsk State Medical University
Russian Federation
Russian Federation
M. F. Osipenko
Novosibirsk State Medical University
Russian Federation
Russian Federation
References
1. Portincasa P., Moschetta A., Palasciano G. Cholesterol gallstone disease // Lancet. 2006. Vol. 368. P. 230-239.
2. Unisa S., Jagannath P., Dhir V. et al. Population-based study to estimate prevalence and determine risk fac-tors of gallbladder diseases in the rural Gangetic basin of North India // HPB (Oxford). 2011. Vol. 13 (2). Р. 117-125.
3. Sun H., Tang H., Jiang S. et al. Gender and metabolic differences of gallstone diseases // World J. Gastroenterol. 2009. Vol. 15. Р. 1886-1891.
4. Schmidt M., Søndenaa K., Vetrhus M., Berhane T., Eide G.E. Long-term follow-up of a randomized controlled trial of observation versus surgery for acute cholecystitis: non-operative management is an option in some patients // Scand. J. Gastroenterol. 2011. Vol. 46. Р. 1251-1256.
5. Parmar A.K., Khandelwal R.G., Mathew M.J., Reddy P.K. Laparoscopic completion cholecystectomy: a ret-rospective study of 40 cases // Asian J. Endosc. Surg. 2013. Vol. 6 (2). Р. 96-99.
6. Matovic E., Hasukic S., Ljuca F., Halilovic H. Quality of life in patients after laparoscopic and open cholecystectomy // Med. Arh. 2012. Vol. 66 (2). Р. 97-100.
7. Aspinen S., Kinnunen M., Harju J. et al. Inflammatory response to surgical trauma in patients with minilaparotomy cholecystectomy versus laparoscopic cholecystectomy: a randomised multicentre study // Scand. J. Gastroenterol. 2016. Vol. 51 (6). Р. 739-744.
8. Pitiakoudis M., Fotakis S.N., Zezos P. et al. Alterations in colonic transit time after laparoscopic versus open cholecystectomy: a clinical study // Tech. Coloproctol. 2011. Vol. 1. Р. 37-41.
9. Hsueh L.N., Shi H.Y., Wang T.F., Chang C.Y., Lee K.T. Health-related quality of life in patients undergoing cholecystectomy // Kaohsiung J. Med. Sci. 2011. Vol. 27 (7). P. 280-288.
10. Schmidt M., Søndenaa K., Vetrhus M., Berhane T., Eide G.E. Randomized controlled study of uncomplicated gallstone disease with a 14-year follow-up showed that operation was the preferred treatment // Dig. Surg. 2011. Vol. 28 (4). Р. 270-276.
11. Agrawal R., Sood K.C., Agarwal B. Evaluation of early versus delayed laparoscopic cholecystectomy in acute cholecystitis // Surg. Res. Pract. 2015. Vol. 2015. ID 349801.
12. Parkman H.P., Yates K., Hasler W.L. et al. Cholecystec-tomy and clinical presentations of gastroparesis // Dig. Dis. Sci. 2013. Vol. 58 (4). Р. 1062-1073.
13. Brazzelli M., Cruickshank M., Kilonzo M. et al. Clinical effectiveness and cost-effectiveness of cholecystectomy compared with observation/conservative management for preventing recurrent symptoms and complications in adults presenting with uncomplicated symptomatic gallstones or cholecystitis: a systematic review and economic evaluation // Health Technol. Assess. 2014. Vol. 18 (55). Р. 1-101.
14. Lamberts M.P., Lugtenberg M., Rovers M.M. et al. Persistent and de novo symptoms after cholecystectomy: a systematic review of cholecystectomy effectiveness // Surg. Endosc. 2013. Vol. 27 (3). Р. 709-718.
15. Ивашкин В.Т., Охлобыстин А.В., Бордин Д.С. и др. Резолюция экспертного совета «Диагностика и лечение больных со сладжем в желчном пузыре» // Рос. журн. гастроэнтерологии, гепатологии, колопроктологии. 2016. Т. 26, № 6. С. 127-134.
16. Лялюкова Е.А., Ливзан М.А. Дисфункция сфинктера Одди и синдром избыточного бактериального роста в кишечнике // Лечащий врач. 2013. № 1. С. 61.
17. Fioramonti J. ROME III: the functional gastrointestinal disorders // J. Gastroent. Hepatol., 2008. Vol. 20 (9). Р. 941.
18. Schmidt M., Søndenaa K., Dumot J.A. et al. Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder // World J. Gastroenterol. 2012. Vol. 18 (12). Р. 1365-1372.
19. Ahmed R., Freeman J.V., Ross B. et al. Long term res-ponse to gallstone treatment - problems and surprises // Eur. J. Surg. 2000. Vol. 166 (6). Р. 447-454.
20. Festi D., Reggiani M.L., Attili A.F. et al. Natural history of gallstone disease: Expectant management or active treatment? Results from a population-based cohort study // J. Gastroent. Hepatol. 2010. Vol. 25 (4). Р. 719-724.
21. Козлова И.В., Граушкина Е.В., Волков С.В. Клинико-функциональные и структурные нарушения гастродуоденальной зоны после холецистэктомии // Врач. 2010. № 9. С. 72-76.
22. Ильченко А.А. Болезни желчного пузыря и желчных путей. М.: МИА, 2011. 880 с.
23. Григорьев П.Я., Яковенко А.В. Клиническая гастроэнтерология. 3-е изд., перераб. и доп. М.: МИА, 2004. 768 с.
24. Thistle J.L., Longstreth G.F., Romero Y. et al. Factors that predict relief from upper abdominal pain after сholecystectomy // Clin. Gastroenterol. Hepatol. 2011. Vol. 9 (10). Р. 891-896.
25. Kirk G., Kennedy R., McKie L., Diamond T., Clements B. Preoperative symptoms of irritable bowel syndrome predict poor outcome after laparoscopic cholecystectomy // Surg. Endosc. 2011. Vol. 25 (10). Р. 3379-3384.
Review
For citations:
Makarova Y.V., Litvinova N.V., Voloshinа N.B., Osipenko M.F. Dynamics of abdominal pain syndrome in patients with cholelithiasis throughout the 10-year follow-up period. Journal of Siberian Medical Sciences. 2018;(4):54-66. (In Russ.) https://doi.org/10.31549/2542-1174-2018-4-54-66
Views:
194
Email this article 