Modern methods of treatment of bacterial vaginosis in women of reproductive age
https://doi.org/10.31549/2542-1174-2019-4-4-11
Abstract
To improve the treatment of bacterial vaginosis and to extend the recurrence-free period, we examined 81 women of reproductive age (18–45 years) with a confirmed diagnosis of bacterial vaginosis. All patients were divided into 2 groups depending on the sensitivity of pathogens to the preparation of polyvalent bacteriophages (phagogine): group I included patients with low sensitivity to phagogine (n = 41) who took a combined drug with antimicrobial, antifungal and antiinflammatory effects (elzhina); patients of group II with high sensitivity to phagogine (n = 40) received combined therapy: elzhina + phagogine. The sensitivity of pathogens was determined by the bacteriological method. The greatest effectiveness (97.5% in group II versus 82.9% in group I) was shown by complex treatment (elzhina + phagogine).
Conflict of interest. The authors declare no conflict of interest.
About the Authors
U. V. PiletskayaRussian Federation
Piletskaya Ulyana Vladimirovna — Assistant of the Obstetrics and Gynecology Department
52, Krasny Prospect, Novosibirsk, 630091
I. O. Marinkin
Russian Federation
Marinkin Igor Olegovich — Dr. Sci. (Med.), Professor, Head of the Obstetrics and Gynecology Department, Rector
K. Yu. Makarov
Russian Federation
Makarov Konstantin Yuryevich — Dr. Sci. (Med.), Professor of the Obstetrics and Gynecology Department
T. M. Sokolova
Russian Federation
Sokolova Tatyana Mikhaylovna — Dr. Sci. (Med.), Professor of the Obstetrics and Gynecology Department
References
1. Rakhmatulina M.R., Malova I.O., Sokolovsky E.V. (2015). The federal сlinical guidelines for the management of patients with bacterial vaginosis. Moscow. Retrieved September 10, 2019 from https://www. ismos.ru/guidelines/doc/bakterial’nyj_vaginoz.pdf. In Russ.
2. O’Hanlon D.E., Moench T.R., Cone R.A. (2013). Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PloS One, 8 (11): e80074. doi: 10.1371/journal.pone.0080074.
3. Wilks M., Wiggins R., Whiley A. et al. (2004). Identifi cation and H2O2 production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with the outcome. J. Clin Microbiol., 42, 713–717. doi: 10.1128/jcm.42.2.713-717.2004.
4. Amaya-Guio J., Viveros-Carreño D., Sierra-Barrios E., Martinez-Velasquez M., Grillo-Ardila C. (2016). Antibiotic treatment for the sexual partners of women with bacterial vaginosis. Cochrane Database Syst. Rev., 10: СD011701.
5. Pestrikova T.Yu., Porubova Ya.P. (2014). Comparative description of Amsel and Nugent criteria for the diagnosis of bacterial vaginosis. Bull. Physiology and Pathology of Respiration, 51, 106–111.
6. Wang H., Huang Z., Wu Z., Qi X., Lin D. (2017, Mar 3). An epidemiological study on vaginitis in 6,150 women of reproductive age in Shanghai. New Microbiol., 40 (2), 113–118.
7. Marinkin I.O., Trunchenko N.V., Seryapina Yu.V. et al. (2017). Chronic endometritis with normal and thin endometrium during treatment of reproductiveage women: ultrasound and histological correlations. Russ. Journal of Human Reproduction, 23 (1), 29– 36.
8. Trunova L.A., Gorbenko O.M., Shvayuk A.P. et al. (2003). Immunobiochemical changes in patients with chronic infectious and inflammatory diseases of the uterine appendages in the stage of clinical remission. Allergology and Immunology, 4 (4), 4–8. In Russ.
9. Volkov V.G., Zaikina F.Ya., Kultygina S.V. (2009). Modern approaches to predicting the occurrence of premature birth. Journal of New Medical Technologies, 16 (4), 112–113. In Russ.
10. Martynenko P.G., Volkov V.G., Zaikina F.Ya., Kuzmina I.V., Loginova T.A. (2010). New aspects of the prevention of preterm birth among patients with symptoms of threatened termination of pregnancy. Journal of New Medical Technologies, 17 (4), 151–153. In Russ.
11. Lamont R.F. (2015). Advances in the prevention of infection-related preterm birth. Front. Immunol., 6, 566.
12. Petricevic L., Domig K., Nierscher F.J. (2014). Characterization of the vaginal Lactobacillus microbiota associated with preterm delivery. Sci. Rep., 4, 51362. doi: 10.1038/srep05136.
13. Piletskaya U.V., Makarov K.Yu. (2017). Search for new approaches to the treatment of non-specifi c vaginal diseases. The intellectual potential of the XXI century: Abstracts. Odessa, 9–12.
14. Gillet E., Meys J.F., Verstaelen H. (2012). Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis. PLoS One, 7 (10), e45201.
Review
For citations:
Piletskaya U.V., Marinkin I.O., Makarov K.Yu., Sokolova T.M. Modern methods of treatment of bacterial vaginosis in women of reproductive age. Journal of Siberian Medical Sciences. 2019;(4):4-11. https://doi.org/10.31549/2542-1174-2019-4-4-11