Community-acquired pneumonia: epidemiology, etiology and clinical-morphological parallels
https://doi.org/10.31549/2542-1174-2019-4-20-29
Abstract
Retrospective assessment of results of pathoanatomical researches on the deceased patients with community-acquired pneumonia treated in City Clinical Hospital No. 1 (Novosibirsk) in 2016–2018 is carried out for the purpose of studying gender, age features, etiology, clinical-morphological forms of the community-acquired pneumonia which resulted in lethal outcome. Morphological and bacteriological researches of lung samples in deceased patients with the diagnosis of pneumonia were conducted.
It is revealed that lethal outcomes owing to community-acquired pneumonia were more often observed in men, than in women, at advanced and senile age (56–67%). The rate of lethal outcomes owing to community-acquired pneumonia among all number of pathoanatomical thanatopsy made 2.6–3.8%. Lethality within the period of 24 hours of hospitalization was registered in 15–32% of cases. The divergence of clinical and pathoanatomical diagnoses reached 17.6%. Klebsiella pneumoniaе, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and also mixed-strain infection were the most widespread verifi ed causative agents of community-acquired pneumonia. The main clinical-morphological form of community-acquired pneumonia was the widespread bronchial pneumonia (purulent, with abscessing) (up to 87.8%) which did not present specifi c morphological picture depending on a type of the causative agent.
Conflict of interest. The authors declare no conflict of interest.
About the Authors
A. P. NadeevRussian Federation
Nadeev Aleksandr Petrovich — Dr. Sci. (Med.), Professor, Head of the Pathological Anatomy Department
Pathologist
M. A. Kozyaev
Russian Federation
Kozyaev Mikhail Aleksandrovich — Cand. Sci. (Med.), Assistant Professor of the Pathological Anatomy Department
Head of the Pathology Department,
A. A. Abyshev
Russian Federation
Abyshev Aleksandr Andreyevich — Post-graduate Student of the Pathological Anatomy Department
M. N. Chekanov
Russian Federation
Chekanov Mikhail Nikolayevich — Dr. Sci. (Med.), Professor of the General Surgery Department
E. M. Blagitko
Russian Federation
Blagitko Evgeny Mikhaylovich — Dr. Sci. (Med.), Professor of the Hospital and Pediatric Surgery Department
I. V. Peshkova
Russian Federation
Peshkova Inessa Viktorovna — Dr. Sci. (Med.), Assistant Professor of the Anesthesiology and Critical Care Medicine n.a. Professor I.P. Vereshchagin Department
E. V. Ovsyanko
Russian Federation
Ovsyanko Elena Vladimirovna — Dr. Sci. (Med.), Professor of the Human Anatomy Department
References
1. Kruglyakova L.V., Naryshkina S.V. (2016). Severe community-acquired pneumonia: diagnostics and treatment (review). Bulletin Physiology and Pathology of Respiration, 59, 98–108.
2. Ewig S., Birkner N., Strauss R. et al. (2009). New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax, 64 (12), 1062–1069.
3. Blagonravova A.S., Chubukova O.A., Shirokova I.Yu., Korotaeva S.V. (2011). Community-acquired pneumonia in hospitalized patients. Epidemiology and Vaccinal Prevention, 6 (61), 71–78.
4. Vyortkin A.L., Zayratyants O.V., Vovk E.I. (2009). Final Diagnosis. Moscow: GEOTAR-Media, 576 p. In Russ.
5. Lin C.J., Chang Y.C., Tsou M.T. et al. (2019 March 14). Factors associated with hospitalization for community-acquired pneumonia in home health care patients in Taiwan. Aging Clin. Exp. Res. doi: 10.1007/ s40520-019-01169-8.
6. Hamaguchi S., Suzuki M., Sasaki K. et al. (2018). Six underlying health conditions strongly infl uence mortality based on pneumonia severity in an ageing population of Japan: a prospective cohort study. BMC Pulm. Med., 18 (1), 88. doi: 10.1186/s12890-018- 0648-y.
7. Woodhead M., Blasi F., Ewig S. et al. (2011). Guidelines for the management of adult lower respiratory tract infections. Clin. Microbiol. Infect., 17 (6), E1–59.
8. Khodosh E.M., Poteyko P.I., Efremova O.A. (2012). Community-acquired pneumonia: opportunities and problems of etiological diagnostics. Belgorod State University Scientifi c Bulletin. Series: Medicine. Pharmacy, 22 (141), 5–11. In Russ.
9. Chuchalin A.G. (2015). Pneumonia as an actual medical problem of the XXI century. Russian Pulmonology, 25, 2, 133–142. In Russ.
10. Chigishchev A.P. (2015). Features of diagnostics and optimization of managing patients with pneumonia. The XXV National Congress Of Respiratory Diseases. Moscow, pp. 168–169. In Russ.
11. Zaytsev A.A. (2018). Community-acquired pneumonia: epidemiology, diagnostics and antimicrobic therapy. Therapy, 1 (19), 63–71. In Russ.
12. Golubev A.M., Smelaya T.V., Moroz V.V. et al. (2010). Community-acquired and nosocomial pneumonia: clinical and morphological features. General Reanimatology, 6 (3), 5–14.
Review
For citations:
Nadeev A.P., Kozyaev M.A., Abyshev A.A., Chekanov M.N., Blagitko E.M., Peshkova I.V., Ovsyanko E.V. Community-acquired pneumonia: epidemiology, etiology and clinical-morphological parallels. Journal of Siberian Medical Sciences. 2019;(4):20-29. https://doi.org/10.31549/2542-1174-2019-4-20-29