Morphometric study of the connective tissue cells of scleral flaps in primary glaucoma depending on the level of the aqueous humor retention
https://doi.org/10.31549/2542-1174-2019-4-75-85
Abstract
In scleral flaps resected during anti-glaucoma surgeries in 60 patients with 6 different forms of primary glaucoma, the content of connective tissue cells — matrix-producing and infi ltrate elements — was studied using comparative morphometric analysis. The scoring of the proximal and distal sclera zones separately with 2 forms of glaucoma with a pretrabular level of the hydrodynamic block revealed a signifi cantly higher number of matrix-producing cells in congenital glaucoma compared with angle-closure one. Analysis of 4 forms of glaucoma with a trabecular block showed a significantly higher content of matrix-producing cells up to the distal drainage pathways in pigmentary and pseudoexfoliation glaucoma which contributes to the development of accelerated retention of the aqueous humor outflow. The polymorphic pattern of structural changes in the connective tissue of the eye drainage system determines the feasibility of using a differentiated algorithm when planning the surgical treatment volume.
About the Authors
A. K. Lazareva
S. Fedorov Eye Microsurgery Federal State Institution
Russian Federation
Lazareva Anastasia Konstantinovna — Ophtalmologist
Russian Federation
Lazareva Anastasia Konstantinovna — Ophtalmologist
O. N. Kuleshova
S. Fedorov Eye Microsurgery Federal State Institution;
Novosibirsk State Medical University
Russian Federation
Russian Federation
Kuleshova Olga Nikolayevna — Dr. Sci. (Med.), Professor, Head of the Ophthalmology Department
Ophtalmologist
S. V. Aidagulova
Novosibirsk State Medical University
Russian Federation
Russian Federation
Aidagulova Svetlana Vladimirovna — Dr. Sci. (Biol.), Professor, Head of the Laboratory of Cell Biology and Fundamental Principles of Reproduction
52, Krasny Prospect, Novosibirsk, 630091
A. V. Volchek
Novosibirsk State Medical University
Russian Federation
Volchek Aleksandr Viktorovich — Junior Researcher, Laboratory of Cell Biology and Fundamental Principles of Reproduction
Russian Federation
Volchek Aleksandr Viktorovich — Junior Researcher, Laboratory of Cell Biology and Fundamental Principles of Reproduction
V. V. Chernykh
S. Fedorov Eye Microsurgery Federal State Institution
Russian Federation
Chernykh Valeryi Vyacheslavovich — Dr. Sci. (Med.), Professor, Director
Russian Federation
Chernykh Valeryi Vyacheslavovich — Dr. Sci. (Med.), Professor, Director
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Review
For citations:
Lazareva A.K., Kuleshova O.N., Aidagulova S.V., Volchek A.V., Chernykh V.V. Morphometric study of the connective tissue cells of scleral flaps in primary glaucoma depending on the level of the aqueous humor retention. Journal of Siberian Medical Sciences. 2019;(4):75-85. https://doi.org/10.31549/2542-1174-2019-4-75-85
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