A method for predicting the risk of stroke in men working under conditions of exposure to general vibration

The aim of the study was to develop a method for predicting the development of stroke in men working under conditions of exposure to general vibration. The survey included 134 men aged 30 to 65 years, who worked 5 or more years by occupation: truck driver (BelAZ-75, general vibration level — 80–116 dB), bus driver (general vibration level — 75–101 dB). The study participants were divided into two groups: the fi rst — 70 men who had a stroke; the second — 64 men with a diagnosis of chronic cerebral ischemia.

Using the method of successive inclusion of variables (Forward Stepwise), the risk factors for stroke in the study group (age, work experience, total cholesterol, taking antihypertensive drugs, the presence of a history of smoking factor) were established and a logistic regression formula was proposed that allows to determine the probability of stroke development. A value equal to or greater than 0.6 obtained by calculation using this formula indicates a high risk of stroke development. The sensitivity of the proposed method was 81.4%, specifi city — 76.6%. The proposed method for predicting the development of stroke in men working under conditions of exposure to general vibration can be used during preventive and periodic medical examinations.

Conflict of interest. The authors declare no conflict of interest.

An application No. 2019116922 has been submitted to Rospatent. Priority date is 31.05.2019.

1. Sanossian N., Obviagele В. (2009). Prevention and management of stroke in very elderly patients. Lancet Neurol., 8 (11), 1031–1041.

2. Lochikhina O.A. (2018). Clinical and epidemiological characteristics of stroke in the Russian Federation: according to the territorial and population register. Abstract of Dr. Sci. (Med.) thesis. Moscow, 51 p. Retrieved Oct 21, 2019 from URL: https://dlib.rsl.ru// viewer/01008700078. In Russ.

3. Trift A.G., Thayabaranathan T., Howard G. et al. (2017). Global stroke statistic. Int. J. Stroke, 12 (1), 13–32. doi: 10.1177/1747493016676285.

4. Rolfs A., Fazekas F., Grittner U. et al. (2013). Acute cerebrovascular disease in the young: the Stroke in Young Fabry Patients study. Stroke, 44 (2), 340–349.

5. Demographic Yearbook of Russia 2017: Statistical compendium (2017). Moscow, 263 p. In Russ.

6. Vlachopoulos С., Xaplanteris Р., Aboyans V. et al. (2015). The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. Atherosclerosis, 241 (2), 507– 532. doi: 10.1016/j.atherosclerosis.2015.05.007.

7. Albus C. (2017). Psychosocial risk factors: Time for action in the lifelong prevention of coronary heart disease. Eur. J. Prevent. Cardiol., 24 (13), 1369–1370. doi: 10.1177/2047487317715770.

8. LaMontagne A.D., Martin A., Page K.M. et al. (2014). Workplace mental health: developing an integrated intervention approach. BMC Psychiatry, 14 (1), 131. doi: 10.1186/1471-244X-14-131.

9. Izmerov N.F. (ed.) (2005). Russian Encyclopedia of Occupational Medicine (2005). Moscow, 656 p. In Russ.

10. Boulanger C.M., Vanhoutte P.M. (2009). The endothelium: a modulator of cardiovascular health and disease. Endothelium, 3 (4), 187–203.

11. Deanfi eld J., Donald A., Ferri S. (2005). Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: A statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J. Hypertension, 23 (1), 7–17.

12. Ermakova M.A., Aftanas L.I., Shpagina L.A. (2014). Peculiarities of the arterial hypertension dynamics depending on occupation and personality. Bulletin of the Siberian Branch of the Russian Academy of Medical Sciences, 34 (4), 30–35.

13. Shpagina L.A., Gerasimenko O.N., Drobyshev V.A., Kuznetsova G.V. (2017). Endothelial hemostatic predictors of cardiovascular risk in patients with vibration disease in combination with the arterial hypertension. Journal of Siberian Medical Sciences, 1, 3–6.

14. Podpalov V.P., Manak N.A., Prokoshina N.R., Schaylivenko A.I. A method for predicting the relative risk of myocardial infarction or stroke in a person with arterial hypertension: patent 17881. The Republic of Belarus: A61B 5 /0402, A61B 5/024, G01N 33/50; No. а20110022. In Russ.

15. Nikolayev V.I., Denisenko N.P., Brega A.V., Glazunova G.M. A method for predicting the risk of acute ischemic stroke in patients not older than 50 years with newly diagnosed hypertension: patent 2648532. The Russian Federation; А61В 5/02; No. 2017113347. In Russ.

16. Katamanova E. V., Nurbayeva D.J. Method for detecting early signs of damage to the nervous system under the infl uence of local and general vibration: patent 2626718: The Russian Federation; A61B 5/0484; No. 2016123627. In Russ.

17. Mancia G., Fagard R., Narkiewicz K. et al. (2013). 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens., 31 (7), 1281–1357.

18. Chazova I.E., Zhernakova Yu. V. (on behalf of experts) (2019). Clinical recommendations. Diagnosis and treatment of arterial hypertension. Systemic hypertension, 16 (1), 6–31. doi: 10.26442/2075082X.2019. 1.190179. In Russ.

19. Oleynikov S.P., Glazunov I.S., Chazova L.V. (1981). Smoking among men and women of different age groups. Therapeutic archive, 2, 5–28. In Russ.

20. Agibalova T.V., Tuchina O.D., Shustov D.I., Mukhin A.A., Gurevich G.L. (2015). Alcohol use reduction strategy as alternative treatment for alcohol dependence. Social and Clinical Psychiatry, 25 (3), 61–68.

21. VandenBos G.R. (2007). APA Dictionary of Psychology. 1st ed. Washington: American Psychological Association.