Effect of heparin and ethanol on orientation exploratory behavior of rats in the Open field test
https://doi.org/10.31549/2542-1174-2020-2-42-49
Abstract
The aim of the study is to assess the effect of heparin and ethanol on the orientation and exploratory behavior (locomotion) of rats in the Open field test. Experimental animals (male rats weighing 200 ± 10 g) were intraperitoneally injected with high molecular heparin and ethyl alcohol and then placed in a behavioral response testing set. It was found that ethanol (5 g/kg) in intraperitoneal administration reduces the parameters of orientation exploratory behavior which does not recover after 24 hours. Heparin in combined injection with ethanol affects the vertical and horizontal activity of rats in different directions, but a recovery of behavioral responses is observed after 24 hours from the moment of administration. Heparin is believed to interact with ethanol to form a complex and partially block the ethanol toxic effect.
About the Authors
A. E. Khomutov
Lobachevsky State University of Nizhni Novgorod
Russian Federation
Russian Federation
Dr. Sci. (Biol.), Professor, Department of Physiology and Anatomy, Institute of Biology and Biomedical Medicine,
Nizhni Novgorod
A. S. Lizunova
Ryazan State Medical University named after academician I.P. Pavlov
Russian Federation
Russian Federation
Cand. Sci. (Biol.), Associate Professor, Pharmacognosy Department,
Ryazan
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Review
For citations:
Khomutov A.E., Lizunova A.S. Effect of heparin and ethanol on orientation exploratory behavior of rats in the Open field test. Journal of Siberian Medical Sciences. 2020;(2):42-49. (In Russ.) https://doi.org/10.31549/2542-1174-2020-2-42-49
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