Evaluation of certain hormonal and metabolic parameters in women of different age groups

Abstract

The analysis of hormonal and metabolic parameters in women of different age groups was carried out. 122 women aged 21 to 70 years were examined (the average age was 41 ± 1.8 years). All women underwent an anthropometric survey to calculate the body mass index and waist-to-hip ratio. The laboratory study included: determination of serum glucose, triglycerides, total cholesterol, high-density lipoprotein cholesterol, immunoreactive insulin, leptin, adiponectin, cortisol, and dehydroepiandrosterone sulfate (DHEA-S). It was revealed that the advance in age in women is accompanied by an  increase in the values of anthropometric parameters, which testifies the accumulation of subcutaneous and visceral fat. The accumulation of adipose tissue and an increase in blood pressure (BP) was associated with hypertriglyceridemia, hyperleptinemia, and DHEA-S decrease. The results of the correlation analysis suggest that the processes of accumulation of excess body weight and the formation of obesity in women with aging are associated, at least partially, with disturbance of adipocytokine fat metabolism regulation. The combination of abdominal obesity, high BP and hypertriglyceridemia in older women being the three main components of the metabolic syndrome testifies to a high risk of cardiovascular diseases.