Pharmacoepidemiological analysis of the use of antimicrobial drugs for diseases of the lower respiratory tract in the pulmonary department of a multifield hospital of the Republic of Tajikistan

Aim. Assessment of the use of antimicrobial drugs (AD) in the pulmonary department of a multifield hospital (MH), the Republic of Tajikistan.

Materials and methods. A retrospective analysis of medical prescriptions of patients who were treated in the pulmonary department of the Sughd Regional Clinical Hospital (city of Khojend, the Republic of Tajikistan) in 2011-2018 was carried out. The use of AD was evaluated in total, by groups in accordance with the WHO ATC/DDD index: penicillins, cephalosporins, aminoglycosides, fluoroquinolones, tetracyclines, and other antibiotics, as well as separately by international nonproprietary names of drugs. The measurable unit was the number of grams of an active substance, followed by the calculation of the indicators DDD/100 bed-days and percentage of total DDD.

Results. Significant changes in the structure of AD used for the initial antibacterial therapy of respiratory tract infections during the study period were revealed. There is a marked tendency to reduce the use of AD of the penicillin family and macrolides, with the transition to monotherapy with cephalosporins of the 3rd generation (ceftriaxone) and partially with fluoroquinolones.

Conclusion. Monitoring the use of AD in hospital departments on basis of the ATC/DDD methodology allows to make strategic decisions regarding the tactics of antibacterial therapy, determine the orientation of administrative measures and improve the range of antibacterial agents with the introduction of the modern effective drugs into practice in the future.

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