Development of hydrophilic gel based on sulfated arabinogalactan
https://doi.org/10.31549/2542-1174-2022-6-1-116-127
Abstract
Introduction. The modern pharmaceutical market offers a very limited range of medicines for the prevention and treatment of chronic venous insufficiency. The original pharmacologically active compound based on the potassium salt of the sulfated derivative of arabinogalactan (Agsular®) is an analog of heparin.
Aim. Development of a hydrophilic gel based on Agsular®.
Materials and Methods. Model compositions were prepared according to traditional methods of gels preparation. The physical and chemical properties of the obtained samples were evaluated by methods of potentiometry, dynamic rheology and dynamic light scattering. The microbiological purity of the gels during storage was also evaluated.
Results. The optimal composition of the hydrophilic gel containing Agsular® (1.5%) as the active substance is substantiated. This is a water-aerosil-glycerol-containing composition (the mixture ratio being 1:2:13 respectively). Studies of pH, dynamic viscosity and zeta potential confirm the stability of this gel. The introduction of a preservative (Nipagin 0.1%) ensures the microbiological purity of the gel during storage.
Conclusion. The developed hydrophilic gel is a promising mean of prevention and treatment of chronic venous insufficiency.
Supporting agencies: The research was carried out with the financial support of the fundamental research Program of the Presidium of the Russian Academy of Sciences “Fundamental Science for Medicine” (2013–2014) No. 5: Project No. 5.40 “Development of a reference medicinal product for the prevention and treatment of chronic venous insufficiency” and Program V.48 “Fundamental physical and chemical studies of the mechanisms of physiological processes and the creation on their basis of pharmacological substances and dosage forms for the treatment and prevention of socially significant diseases” (2013– 2020): Project V.48.1.2 “Search for new biologically active substances based on the biomass of coniferous species of Siberia and the Far East, screening of the biological activity of promising compounds. Development of technologies for obtaining natural substances and determination of their practical significance.”
About the Authors
V. V. Kostyro
A.E. Favorsky Irkutsk Institute of Chemistry
Russian Federation
Russian Federation
Applicant, Group of Pharmaceutical Development
1, Favorsky str., Irkutsk, 664033, Russia
Ya. A. Kostyro
A.E. Favorsky Irkutsk Institute of Chemistry
Russian Federation
Russian Federation
Cand. Sci. (Pharmaceut.), Senior Researcher, Group of Pharmaceutical Development
1, Favorsky str., Irkutsk, 664033, Russia
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Review
For citations:
Kostyro V.V., Kostyro Ya.A. Development of hydrophilic gel based on sulfated arabinogalactan. Journal of Siberian Medical Sciences. 2022;(1):116-127. https://doi.org/10.31549/2542-1174-2022-6-1-116-127
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