Coronary artery disease with intermediate coronary artery stenosis. Clinical peculiarities. The chronological age and biological age ratio
https://doi.org/10.31549/2542-1174-2022-6-4-37-47
Abstract
Introduction. Coronary artery disease (CAD) remains the main cause of disability and mortality among workingage people. A signifi cant part of stable angina patients are patients with intermediate (40–70 %) coronary artery stenosis.
Aim. To study cardiovascular risk factors and make a comparative assessment of the clinical angiographic picture and vascular stiff ness in stable angina patients with intermediate coronary artery stenosis, depending on the chronological age / biological age ratio, as well as to determine the level of long-term metabolites of nitric oxide (NO) – nitrites (NO2).
Materials and methods. 40 stable angina class I–III patients (36 men) aged 33–68 years with intermediate coronary artery stenosis were examined. Depending on the values of the chronological age / biological age coeffi cient (K), the patients were divided into two groups. The 1st group included patients with a biological age exceeding the passport age (K < 1.0 [0.53; 0.98]), the 2nd group included patients with a biological age equal or inferior to the chronological age (K ≥ 1.0 [1.1; 1.5], p < 0.01 ).
Results. Stable angina patients with intermediate coronary artery stenosis represent a rather challenging group of people in terms of prognosis. Patients with increased biological age are characterized by an unfavorable course of the disease and a less favorable cardiometabolic profi le compared to patients whose biological age corresponded to the chronological one. At the same time, the level of long-term metabolites of nitric oxide (NO) – nitrites (NO2) in plasma did not depend on the biological age of patients.
Conclusion. The study of the biological age and level of long-term metabolites of nitric oxide (NO) – nitrites (NO2) in stable CAD patients with intermediate coronary artery stenosis is of great interest and requires further research.
About the Authors
D. A. YakhontovRussian Federation
Davyd A. Yakhontov, Dr. Sci. (Med.), Professor
Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine
Novosibirsk
Yu. O. Ostanina
Russian Federation
Yulia O. Ostanina, Cand. Sci. (Med.), Associate Professor
Department of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine
630091
52, Krasny prosp.
Novosibirsk
A. P. Lykov
Russian Federation
Alexander P. Lykov, Cand. Sci. (Med.), Senior Researcher
Novosibirsk
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Review
For citations:
Yakhontov D.A., Ostanina Yu.O., Lykov A.P. Coronary artery disease with intermediate coronary artery stenosis. Clinical peculiarities. The chronological age and biological age ratio. Journal of Siberian Medical Sciences. 2022;(4):37-47. https://doi.org/10.31549/2542-1174-2022-6-4-37-47